Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

The effect of the anti-angiogenic drug sunitinib malate on the vascular architecture of oral squamous cell carcinoma

(2014) ViníCius Faccin Bampi et al.   MICROSCOPY RESEARCH AND TECHNIQUE

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

(2014) Olga Martinho et al.   Translational Oncology

Control of the Immune Response by Pro-Angiogenic Factors

(2014) Thibault Voron et al.   Frontiers in Oncology

Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer

(2013) Cristina Iclozan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer

(2013) D. Alizadeh et al.   CANCER RESEARCH

Long-Term Response to Sunitinib Therapy for Metastatic Renal Cell Carcinoma

(2013) Ana M. Molina et al.   Clinical Genitourinary Cancer

Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

(2013) Ritika Jaini et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic immunization and local low-dose tumor irradiation, a reinforcing combination

(2013) Oana Draghiciu et al.   INTERNATIONAL JOURNAL OF CANCER

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

Systemic Treatment Options for Untreated Patients With Metastatic Clear Cell Renal Cancer

(2013) Ana M. Molina et al.   SEMINARS IN ONCOLOGY

Myeloid-Derived Suppressor Cells Interact with Tumors in Terms of Myelopoiesis, Tumorigenesis and Immunosuppression: Thick as Thieves

(2013) Alexandra Sevko et al.   Journal of Cancer

iNOS-selective inhibitors for cancer prevention: promise and progress

(2012) Naveena B Janakiram et al.   Future Medicinal Chemistry

Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells

(2012) Anabel Sorolla et al.   Molecular Oncology

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

(2012) Minu K. Srivastava et al.   PLoS One

Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system

(2011) Mateusz Walczak et al.   ANTIVIRAL THERAPY

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

(2011) M. W. Nasser et al.   CANCER RESEARCH

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

(2011) A. M. Lesokhin et al.   CANCER RESEARCH

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

(2011) James Finke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy

(2011) Benedetto Farsaci et al.   INTERNATIONAL JOURNAL OF CANCER

Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model

(2011) Mengde Cao et al.   LABORATORY INVESTIGATION

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained

(2010) Jennifer S. Ko et al.   CANCER RESEARCH

Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors

(2010) Maria Sharmila A. Sousa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens

(2010) Annechien J.A. Lambeck et al.   VACCINE

Molecular basis and management of gastrointestinal stromal tumors

(2010) Ulas D Bayraktar   WORLD JOURNAL OF GASTROENTEROLOGY

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

(2009) J. S. Ko et al.   CLINICAL CANCER RESEARCH

Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells

(2009) Eliana Ribechini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses

(2008) M. M. Hipp et al.   BLOOD

Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells

(2008) P. Serafini et al.   CANCER RESEARCH

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION