Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Fatty acid transport protein 2 reprograms neutrophils in cancer

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Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

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LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

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The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates

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IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development

(2018) Isatou Bah et al.   CELLULAR IMMUNOLOGY

Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity

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Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells

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Activation of SREBP1-mediated lipogenesis by the Epstein-Barr Virus-encoded LMP1 promotes cell proliferation and progression of nasopharyngeal carcinoma

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Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation

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Lipid Droplets as Immune Modulators in Myeloid Cells

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Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development

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Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer

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Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

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Diversity and environmental adaptation of phagocytic cell metabolism

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Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

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PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review)

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Roles of Myeloid-Derived Suppressor Cell Subpopulations in Autoimmune Arthritis

(2018) Min Li et al.   Frontiers in Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

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Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway

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Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy

(2017) Chiara Porta et al.   FEBS Journal

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

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Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

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Myeloid-Derived Suppressor Cells: key players mediating immunosuppression via induction of Regulatory T-cell by TGFβ and IL-10 driven pathways in chronic HBV infection

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Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

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Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology

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Energy metabolic pathways control the fate and function of myeloid immune cells

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ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Macrophage Immunometabolism: Where Are We (Going)?

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Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis

(2017) Shiou-Ling Jian et al.   Cell Death & Disease

The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury

(2017) Chao Zhang et al.   Cell Death & Disease

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

(2017) Krishnendu Chakraborty et al.   Nature Communications

TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways

(2017) Kaili Lian et al.   Oncotarget

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

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Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells

(2017) Hao Wu et al.   Scientific Reports

MDSCs in cancer: Conceiving new prognostic and therapeutic targets

(2016) Francesco De Sanctis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

17β-Oestradiol enhances the expansion and activation of myeloid-derived suppressor cells via signal transducer and activator of transcription (STAT)−3 signalling in human pregnancy

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IL-9 promotes the survival and function of human melanoma-infiltrating CD4+CD8+double-positive T cells

(2016) Tiphaine Parrot et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effect of HCV clearance with direct-acting antiviral agents on HCC

(2016) Josep M. Llovet et al.   Nature Reviews Gastroenterology & Hepatology

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

(2016) Xinfeng Chen et al.   Oxidative Medicine and Cellular Longevity

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

(2016) Yaqing Chen et al.   Oncotarget

Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2

(2016) Yuan Rong et al.   Scientific Reports

Effects of Interferons and Viruses on Metabolism

(2016) Stephanie Deborah Fritsch et al.   Frontiers in Immunology

Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer

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Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator

(2016) Prashant Trikha et al.   OncoImmunology

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

(2015) Bing Liu et al.   Cancer Cell International

Abstract 467: Oxidized lipids contribute to the suppression function of myeloid derived suppressor cells in cancer

(2015) Filippo Veglia et al.   CANCER RESEARCH

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis

(2015) Ting Zhao et al.   Oncotarget

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation

(2014) Osama Abo Alrob et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Signaling pathways involved in MDSC regulation

(2014) Prashant Trikha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer

(2014) Svetlana A. Fayngerts et al.   CANCER CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma

(2014) S. Kusmartsev et al.   JOURNAL OF IMMUNOLOGY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

TIPE2 Negatively Regulates Inflammation by Switching Arginine Metabolism from Nitric Oxide Synthase to Arginase

(2014) Yunwei Lou et al.   PLoS One

Tumor-specific IL-9–producing CD8+Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers

(2014) Yong Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity

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Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway

(2013) Dehong Yan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Enhanced Atherosclerosis in TIPE2-Deficient Mice Is Associated with Increased Macrophage Responses to Oxidized Low-Density Lipoprotein

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Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Le cancer comme intrusion : réflexions psychopathologiques sur certaines modalités de réaction dans l’après-coup de l’annonce

(2013) J. -L. Pujol et al.   Psycho-Oncologie

Polarization and reprogramming of myeloid-derived suppressor cells

(2013) W.-C. Yang et al.   Journal of Molecular Cell Biology

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models

(2012) Ines Hammami et al.   BMC CELL BIOLOGY

Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology

(2012) Claudia A. Dumitru et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Polarizing Macrophages through Reprogramming of Glucose Metabolism

(2012) Julianna Blagih et al.   Cell Metabolism

Th9 cells promote antitumor immune responses in vivo

(2012) Yong Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A novel strategy for modulation of MDSC to enhance cancer immunotherapy

(2012) Tomar Ghansah   OncoImmunology

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

(2011) N. Obermajer et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Circulating and tumor-infiltrating myeloid cell subsets in patients with bladder cancer

(2011) Evgeniy Eruslanov et al.   INTERNATIONAL JOURNAL OF CANCER

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

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Essential role of Stat3 in PI3K-induced oncogenic transformation

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Macrophages, innate immunity and cancer: balance, tolerance, and diversity

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Myeloid-derived suppressor cell heterogeneity and subset definition

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The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

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Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

A Role for Immature Myeloid Cells in Immune Senescence

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Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells

(2009) Moses K. Donkor et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2

(2009) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

(2008) Honghong Sun et al.   CELL

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

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