Article
Oncology
Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Laurie Tonon, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Arnaud de la Fouchardiere, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Christophe Caux, Stephane Dalle, Julie Caramel
Summary: This study reveals that ZEB1 expression in melanoma cells is associated with decreased CD8(+) T cell infiltration, leading to tumor immune evasion and resistance to immune checkpoint blockade. ZEB1 directly represses the secretion of T cell-attracting chemokines, such as CXCL10, and targeting ZEB1 may enhance the efficacy of immunotherapy in melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Naiyer Rizvi, Foluso O. Ademuyiwa, Z. Alexander Cao, Helen X. Chen, Robert L. Ferris, Sarah B. Goldberg, Matthew D. Hellmann, Ranee Mehra, Ina Rhee, Jong Chul Park, Harriet Kluger, Hussein Tawbi, Ryan J. Sullivan
Summary: Although immunotherapy can benefit patients with difficult-to-treat cancers, many tumors don't respond or progress after initial control. Combination therapy with immunotherapy and chemotherapy has shown improved response rates in solid tumors. However, designing trials for tumors that do not respond to immunotherapy is challenging without standardized definitions of resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Neurosciences
Xu Guo, Gang Wang
Summary: This review explores the mechanisms by which glioma cells suppress antitumor immune responses and produce escape, with a focus on immune cell differentiation and function in the tumor microenvironment. A deeper understanding of immune response and evasion mechanisms in glioma is needed to develop more effective treatment modalities.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Oncology
Yunbo He, Jinliang Huang, Qiaorong Li, Weiping Xia, Chunyu Zhang, Zhi Liu, Jiatong Xiao, Zhenglin Yi, Hao Deng, Zicheng Xiao, Jiao Hu, Huihuang Li, Xiongbing Zu, Chao Quan, Jinbo Chen
Summary: The status and composition of gut microbiota have a profound impact on human antitumor immunity by influencing immune cells and inflammatory factors. Protecting and optimizing gut microbiota can improve the efficacy of immunotherapy, bringing new hope for cancer treatment.
Review
Pharmacology & Pharmacy
Chunping Liu, Dongyue He, Longmei Li, Shihui Zhang, Lei Wang, Zhijin Fan, Yichao Wang
Summary: This review aims to explore the role of extracellular vesicles (EVs) in immune escape in pancreatic cancer (PC) and their potential in cancer immunotherapy. Despite significant progress in clinical trials of immunotherapies for various cancers, the effectiveness of immunotherapy is still low in PC, possibly due to immune evasion mechanisms. Therefore, investigating the role of EVs in immune escape in PC is crucial for developing more effective immunotherapies.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Weiqiang You, Jian Ouyang, Zerong Cai, Yufeng Chen, Xiaojian Wu
Summary: This study identifies mRNA vaccine targets for stomach adenocarcinoma (STAD), including ADAMTS18, COL10A1, PPEF1, and STRA6. Patients with immune subtypes (IS) IS1 and IS2 are suitable for mRNA vaccination immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yubiao Lin, Kaida Huang, Zhezhen Cai, Yide Chen, Lihua Feng, Yingqin Gao, Wenhui Zheng, Xin Fan, Guoqin Qiu, Jianmin Zhuang, Shuitu Feng
Summary: This study provides assistance for personalized therapy for gastric cancer through exosome-based classification. The results show that exosome-relevant phenotype B has a poorer prognosis, an inflamed tumor microenvironment, and higher responses to the anti-CTLA4 inhibitor. The exosome-based gene signature can independently and accurately predict gastric cancer prognosis, which is linked to stromal activation and immunosuppression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Lisanne Heim, Zuqin Yang, Patrick Tausche, Katja Hohenberger, Mircea T. Chiriac, Julia Koelle, Carol-Immanuel Geppert, Katerina Kachler, Sarah Miksch, Anna Graser, Juliane Friedrich, Rakshin Kharwadkar, Ralf J. Rieker, Denis I. Trufa, Horia Sirbu, Markus F. Neurath, Mark H. Kaplan, Susetta Finotto
Summary: IL-9 drives immune evasion in lung cancer by promoting tumor cell survival and affecting tumor infiltrating T cells. Blocking IL-9 emerges as a new approach for clinical therapy of lung cancer, as it can suppress tumor growth and promote tumor rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoxu Li, Yinlin Guo, Minmin Xiao, Wenling Zhang
Summary: Tumor cells are capable of evading immune system surveillance, favoring tumor invasion, metastasis, treatment resistance, and recurrence. Epstein-Barr virus (EBV) infection in nasopharyngeal carcinoma (NPC) contributes to a suppressive tumor microenvironment (TME), characterized by the co-existence of EBV-infected NPC cells and tumor-infiltrating lymphocytes. Understanding the interaction between EBV and NPC host cells and the immune escape mechanisms in the TME could lead to the identification of specific immunotherapy targets and the development of effective immunotherapy drugs.
Review
Biochemistry & Molecular Biology
Wei Li, Yi Hao, Xingda Zhang, Shouping Xu, Da Pang
Summary: This review summarizes the existing knowledge on N-6-methyladenosine (m(6)A) modifications involved in tumor immune escape (TIE), explores their potential mechanisms, and provides an overview of available drugs targeting m(6)A modifications.
Article
Oncology
Marit J. van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J. C. van Stigt Thans, Thorbald Van Hall, Sjoerd H. van der Burg
Summary: A small population of CD163(hi) tissue-resident macrophages is identified to be responsible for primary and secondary resistance against T-cell-based immunotherapies. While these CD163(hi) M2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Chunwan Lu, Zhuoqi Liu, John D. Klement, Dafeng Yang, Alyssa D. Merting, Dakota Poschel, Thomas Albers, Jennifer L. Waller, Huidong Shi, Kebin Liu
Summary: Despite the expression of PD-L1 in tumor cells and T lymphocytes, human pancreatic cancer does not respond to immune checkpoint inhibitor immunotherapy. Epigenome dysregulation leads to T cell exhaustion and non-response to immunotherapy. OPN compensates for the function of PD-L1 in promoting immune escape in pancreatic cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Ricardo M. Sainz, Jorge Humberto Rodriguez-Quintero, Maria Constanza Maldifassi, Brendon M. Stiles, Erik Wennerberg
Summary: While the expression of P2X7 receptor on tumor cells promotes cancer growth and metastasis, its expression by the host immune system is essential for coordinating immune responses against cancer. However, there are conflicting roles of P2X7 receptor in regulating immune responses to tumors, making it challenging to develop P2X7 receptor modulators for cancer treatment. This review discusses the prognostic value of P2X7 receptor in cancer, current approaches targeting P2X7 receptor in tumor models, and how tumors manipulate immune responses through P2X7 receptor to promote immune escape. Alternative strategies to overcome tumor immune escape via P2X7 receptor for enhancing immunotherapeutic strategies in cancer patients are also discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Gui Chen, Jiajun Huang, Hehua Lei, Fang Wu, Chuan Chen, Yuchen Song, Zheng Cao, Ce Zhang, Cui Zhang, Yuxi Ma, Mingtao Huang, Jinlin Zhou, Yujing Lu, Yanxia Zhao, Limin Zhang
Summary: This study demonstrates that icariside I can effectively block the kynurenine-AhR pathway and tumor immune escape, suggesting its potential as a small molecule drug for tumor immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Dominik Pfister, Nicolas Gonzalo Nunez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Mueller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jorn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jorg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rossler, Alexander Siebenhuner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Mueller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kutting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Summary: The study investigated the impact of NASH on immunotherapy response in HCC patients and found that NASH-HCC may be less responsive to immunotherapy. Aberrant T cell activation caused by NASH-related tissue damage led to impaired immune surveillance in HCC patients.
Article
Immunology
Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk, Nils Wirges, Katja Steiger, Daniel Haeussler, Percy Knolle, Emily Poulton, Rama Khokha, Barbara T. Gruenwald, Ihsan Ekin Demir, Achim Krueger
Summary: This study uncovers a sex disparity in liver metastasis independent of lifestyle, with TIMP1 playing a role in promoting liver metastasis in male pancreatic cancer patients and mice. Identifying subpopulations with increased TIMP1 levels may have implications for precision medicine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Balazs Jori, Stefanie Schatz, Len Kaller, Bettina Kah, Julia Roeper, Hayat O. Ramdani, Linda Diehl, Petra Hoffknecht, Christian Grohe, Frank Griesinger, Markus Tiemann, Lukas C. Heukamp, Markus Falk
Summary: This study utilized liquid biopsy to detect molecular alterations in NSCLC patients during disease progression on osimertinib treatment, showcasing examples of polyclonal resistance development and highlighting the clinical utility of HC NGS over single gene testing.
Article
Biochemistry & Molecular Biology
Ludmilla Unrau, Jessica Endig, Diane Goltz, Paulina Sprezyna, Hanna Ulrich, Julia Hagenstein, Bernd Geers, Karina Kaftan, Lukas Carl Heukamp, Gisa Tiegs, Linda Diehl
Summary: This study examined the impact of Smad7 expression in myeloid cells on liver inflammation, injury, and fibrosis induction during chronic hepatic inflammation. The results showed that myeloid-specific knock-down of Smad7 did not affect the extent of chronic liver injury and inflammation induced by long-term application of CCl4. Therefore, Smad7 expression in myeloid cells and its potential effects on the TGF-beta-signalling pathway are dispensable for regulating chronic liver injury and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
H. O. Ramdani, M. Falk, L. C. Heukamp, S. Schatz, M. Tiemann, C. Wesseler, L. Diehl, E. Schuuring, H. J. M. Groen, F. Griesinger
Summary: In this study, the expression of 5 immune-related biomarkers (CD73, CD39, VISTA, Arl4d, and Cytohesin-3) in advanced NSCLC patients receiving single agent ICI therapy was evaluated for its association with treatment response. The results showed that the expression of these biomarkers, as well as PD-L1 and TMB, were not predictive of treatment response. Resistance mutations were low frequency and only observed in non-responders. Further validation in larger cohorts is needed to confirm these findings.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Alexandra Linke, Hakan Cicek, Anne Mueller, Catherine Meyer-Schwesinger, Simon Melderis, Thorsten Wiech, Claudia Wegscheid, Julius Ridder, Oliver M. Steinmetz, Linda Diehl, Gisa Tiegs, Katrin Neumann
Summary: This study found that proximal tubular epithelial cells (PTECs) have the capacity for antigen cross-presentation, which can modulate the immune response in immune-mediated glomerular diseases, such as lupus nephritis.
Article
Cell Biology
Bernd Geers, Julia Hagenstein, Jessica Endig, Hanna Ulrich, Laura Fleig, Paulina Sprezyna, Julita Mikulec, Lukas Heukamp, Gisa Tiegs, Linda Diehl
Summary: Arl4d restricts IL-2 production and responsiveness, thereby limiting the conversion of conventional CD4 T cells into T-regulatory cells.
Article
Cell Biology
Celina Eckfeld, Benjamin Schoeps, Daniel Haeussler, Julian Fraedrich, Felix Bayerl, Jan Philipp Boettcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krueger
Summary: The study reveals that TIMP-1 interacts with APP family members and triggers monocyte activation, leading to proinflammatory cytokine expression. This mechanism is confirmed in clinical cancer samples and suggests that TIMP-1 can be a potential therapeutic target for inflammatory diseases.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwaelder
Summary: The liver plays a central role in metabolism and immune functions. When overwhelmed by obesity and a sedentary lifestyle, it can lead to the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Genetic and environmental factors, including the gut microbiome, also contribute to the development and progression of NAFLD and liver cancer. CD8+CXCR6+PD1+ T cells are implicated in the transition from NASH to hepatocellular carcinoma (HCC), and their characteristics may affect responses to immune checkpoint inhibitors. This review focuses on the role of T cells in NASH and discusses preventive measures and therapeutic strategies for managing NASH-HCC.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Silvia Wuerstle, Alexander Hapfelmeier, Siranush Karapetyan, Fabian Studen, Andriana Isaakidou, Tillman Schneider, Roland M. Schmid, Stefan von Delius, Felix Gundling, Rainer Burgkart, Andreas Obermeier, Ulrich Mayr, Marc Ringelhan, Sebastian Rasch, Tobias Lahmer, Fabian Geisler, Paul E. Turner, Benjamin K. Chan, Christoph D. Spinner, Jochen Schneider
Summary: Ascitic fluid infection is a serious complication of liver cirrhosis, and it is crucial to distinguish between spontaneous bacterial peritonitis (SBP) and secondary peritonitis in these patients due to different treatment approaches. This study analyzed 532 SBP episodes and 37 secondary peritonitis episodes to identify key differentiation criteria. Microbiological characteristics, severity of illness, and clinicopathological parameters were identified as the most important predictors to distinguish between SBP and secondary peritonitis. A point-score model with ten discriminatory features was established, and two cut-off scores were defined to divide patients into low-risk and high-risk groups for secondary peritonitis based on a sensitivity of 95% to rule out or rule in SBP episodes. Overall, the discrimination between secondary peritonitis and SBP remains challenging, but the findings of this study may help clinicians with the crucial differentiation.
Article
Multidisciplinary Sciences
Valter Bergant, Daniel Schnepf, Niklas de Andrade Kraetzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Summary: Bergant et al. provide evidence that Influenza A viruses cause alternative polyadenylation of host mRNAs, leading to an attenuated phenotype in mice. This may constitute a common immune evasion mechanism employed by a variety of pathogenic viruses.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Jochen M. Wettengel, Katharina Strehle, Catharina von Lucke, Hedwig Roggendorf, Samuel D. Jeske, Catharina Christa, Otto Zelger, Bernhard Haller, Ulrike Protzer, Percy A. Knolle
Summary: This study demonstrates the usefulness of a second-generation rapid antigen test for early detection of infection with the SARS-CoV-2 Omicron variant of concern (VoC) and reveals a higher sensitivity to detect immune escape Omicron VoCs compared to a first-generation rapid antigen test (89.4% vs 83.7%) in the high-risk group of healthcare workers.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Lydia Meder, Alexandra Florin, Luka Ozretic, Marieke Nill, Mirjam Koker, Sonja Meemboor, Freddy Radtke, Linda Diehl, Roland T. Ullrich, Margarete Odenthal, Reinhard Buettner, Lukas C. Heukamp
Summary: This study showed that Notch1 deficiency contributes to the development of lung adenocarcinomas by increasing TAZ expression in a subgroup of patients with mutated Kras driven lung tumors. The findings suggest potential benefits of TAZ signaling blockade in these patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Review
Immunology
Andrea Kristina Horst, Kingsley Gideon Kumashie, Katrin Neumann, Linda Diehl, Gisa Tiegs
Summary: The liver is a crucial immunological organ responsible for maintaining immune balance through interactions between different cells within the liver. Disruption of this balance in response to pathogens or autoantigens may lead to autoimmune liver diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Dominik Pfister, Nicolas Gonzalo Nunez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Muller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jorn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jorg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rossler, Alexander Siebenhuner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Muller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kutting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Summary: The text discusses the impact of NASH on the development of HCC and the effect of immunotherapy, revealing the accumulation of exhausted and unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, anti-PD1 treatment led to an increase in HCC, with CD8(+) T cells contributing to this increase.