Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Neuroinflammation in Alzheimer's disease and beneficial action of luteolin

(2021) Alejandro Delgado et al.   BIOFACTORS

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

(2020) Wenhua Liang et al.   LANCET ONCOLOGY

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

(2020) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

(2020) Theoharis C. Theoharides   BIOFACTORS

The COVID-19 Pandemic: Setting the Mental Health Research Agenda

(2020) Joshua A. Gordon et al.   BIOLOGICAL PSYCHIATRY

COVID-19 pandemic and mental health consequences: systematic review of the current evidence

(2020) Nina Vindegaard et al.   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Stress, Inflammation, and Autoimmunity: The 3 Modern Erinyes

(2020) Theoharis C. Theoharides   CLINICAL THERAPEUTICS

Effect of Stress on Neuroimmune Processes

(2020) Theoharis C. Theoharides   CLINICAL THERAPEUTICS

Novel coronavirus disease 2019 ( COVID ‐19) and neurodegenerative disorders

(2020) Anurag Kumar Singh et al.   Dermatologic Therapy

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

(2020) Lien D Nguyen et al.   EMBO Molecular Medicine

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

(2020) Tobias Herold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis

(2020) Charlotte Steenblock et al.   MOLECULAR PSYCHIATRY

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

The impact of psychological stress on mast cells

(2020) Theoharis C. Theoharides   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Doxorubicin chemotherapy-induced “chemo-brain”: Meta-analysis

(2020) Sarah Eide et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurobiology of COVID-19

(2020) Majid Fotuhi et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

(2020) Alessio Mazzoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19

(2020) Fang Liu et al.   JOURNAL OF CLINICAL VIROLOGY

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

(2020) Souhel Najjar et al.   Journal of Neuroinflammation

Autoimmune and inflammatory diseases following COVID-19

(2020) Caroline Galeotti et al.   Nature Reviews Rheumatology

COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation

(2020) Duraisamy Kempuraj et al.   NEUROSCIENTIST

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

(2020) Leora R. Feldstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic

(2020) Michael Levin   NEW ENGLAND JOURNAL OF MEDICINE

Mental Health and the Covid-19 Pandemic

(2020) Betty Pfefferbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19 and the Immune System

(2020) J PACES et al.   PHYSIOLOGICAL RESEARCH

Weathering the Cytokine Storm in COVID-19: Therapeutic Implications

(2020) Giulia Iannaccone et al.   CardioRenal Medicine

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

(2020) Duraisamy Kempuraj et al.   BIOFACTORS

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

(2020) Camila Rosat Consiglio et al.   CELL

Roles of flavonoids against coronavirus infection

(2020) Maria Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Coronavirus 2019, Microthromboses, and Platelet Activating Factor

(2020) Theoharis C. Theoharides et al.   CLINICAL THERAPEUTICS

Psychiatry and COVID-19

(2020) Dost Öngür et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Highways to hell: mechanism based management of Cytokine Storm Syndromes

(2020) Scott W. Canna et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

(2020) Ana Copaescu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A role for quercetin in coronavirus disease 2019 (COVID‐19)

(2020) Giuseppe Derosa et al.   PHYTOTHERAPY RESEARCH

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

(2020) Jarbas da Silva Motta Junior et al.   Frontiers in Immunology

Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome

(2020) Abdul Mannan Baig   ACS Chemical Neuroscience

Microvascular Injury in the Brains of Patients with Covid-19

(2020) Myoung-Hwa Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential association of mast cells with coronavirus disease 2019

(2020) Theoharis C. Theoharides   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Clearing the Fog surrounding Chemobrain

(2019) David H. Gutmann   CELL

Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer’s Disease

(2019) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders?

(2019) Theoharis C. Theoharides et al.   Expert Review of Clinical Immunology

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences

(2019) Benjamin H. Natelson   CLINICAL THERAPEUTICS

Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary

(2019) Spencer Richman et al.   CLINICAL THERAPEUTICS

Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of many cancer survivors

(2019) Xiaojia Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

(2019) Sara Emad El-Agamy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect

(2019) Seonhwa Lee et al.   Journal of Clinical Medicine

The roles of Flavonoles/Flavonoids in Neurodegeneration and Neuroinflammation

(2019) Zehra Calis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Aberrant adaptive myelination in ‘chemobrain’

(2019) Isobel Leake   NATURE REVIEWS NEUROSCIENCE

Mast Cell Responses to Viruses and Pathogen Products

(2019) Jean S. Marshall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Similar neurocognitive patterns in patients treated with lenalidomide: chemobrain effect?

(2019) Elisa Calvi et al.   NEUROCASE

Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment

(2019) Erin M. Gibson et al.   CURRENT OPINION IN ONCOLOGY

Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke

(2019) Jesús Calahorra et al.   Nutrients

IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin

(2019) Mona Abubakr Bawazeer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions

(2019) Benjamin Ongnok et al.   EXPERIMENTAL NEUROLOGY

Hydroxytyrosol: A natural compound with promising pharmacological activities

(2019) Matteo Bertelli et al.   JOURNAL OF BIOTECHNOLOGY

Mast cells as sources of cytokines, chemokines, and growth factors

(2018) Kaori Mukai et al.   IMMUNOLOGICAL REVIEWS

Mast cells signal their importance in health and disease

(2018) Ana Olivera et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review

(2018) Zeinab Ashaari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

(2018) Erifili Hatziagelaki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin

(2018) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Olive Biophenols Reduces Alzheimer’s Pathology in SH-SY5Y Cells and APPswe Mice

(2018) Syed Omar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of IL-33 on de novo synthesized mediators from human mast cells

(2018) Theoharis C. Theoharides et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation

(2018) Ruth Hornedo-Ortega et al.   Frontiers in Cellular Neuroscience

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Bioactivity of Olive Oil Phenols in Neuroprotection

(2017) Cristina Angeloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells

(2017) Arti B. Patel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Safety Aspects of the Use of Quercetin as a Dietary Supplement

(2017) Susanne Andres et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mast cells in neuroinflammation and brain disorders

(2017) Erik Hendriksen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

(2017) Stephen D. Skaper et al.   NEUROSCIENTIST

Dysregulation of cytokine mediated chemotherapy induced cognitive impairment

(2017) Xiaojia Ren et al.   PHARMACOLOGICAL RESEARCH

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

(2017) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to Identify and Manage Cognitive Dysfunction After Breast Cancer Treatment

(2017) Marie Lange et al.   Journal of Oncology Practice

Chemobrain: An Opportunity in Cancer Survivorship to Enhance Patient Wellness

(2017) Wendy Baer   Journal of Oncology Practice

Induction of Microglial Activation by Mediators Released from Mast Cells

(2016) Xiang Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

(2016) Fiorella Casamenti et al.   Expert Review of Neurotherapeutics

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

(2016) Nayely Leyva-López et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

(2016) Avanti Desai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis

(2016) Xiang Zhang et al.   Journal of Neuroinflammation

Rethinking policy perspectives on childhood stunting: time to formulate a structural and multifactorial strategy

(2016) S V Subramanian et al.   Maternal and Child Nutrition

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

(2016) HUIMIN WANG et al.   Molecular Medicine Reports

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

(2016) Arti B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

The Role of Mast Cells in Alzheimer’s Disease

(2016) Yasdani Shaik-Dasthagirisaheb et al.   Advances in Clinical and Experimental Medicine

Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

(2016) Fiorella Casamenti et al.   Expert Review of Neurotherapeutics

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

(2016) Maria Fiorentino et al.   Molecular Autism

Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases

(2015) Lawrence B. Afrin et al.   BRAIN BEHAVIOR AND IMMUNITY

Chemobrain: A critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy

(2015) Xiao-Min Wang et al.   CYTOKINE

The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

(2015) Zuyi Weng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression

(2015) A Mayado et al.   LEUKEMIA

Mast Cells, Mastocytosis, and Related Disorders

(2015) Theoharis C. Theoharides et al.   NEW ENGLAND JOURNAL OF MEDICINE

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

(2015) I Tsilioni et al.   Translational Psychiatry

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

(2015) Theoharis C. Theoharides   Frontiers in Neuroscience

The role of IL-33 and mast cells in allergy and inflammation

(2015) Rohit Saluja et al.   Clinical and Translational Allergy

Immune cells in term and preterm labor

(2014) Nardhy Gomez-Lopez et al.   Cellular & Molecular Immunology

Brain Inflammation, Neuropsychiatric Disorders, and Immunoendocrine Effects of Luteolin

(2014) Theoharis C. Theoharides et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats

(2014) Xiaobin Fu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chemobrain Experienced by Breast Cancer Survivors: A Meta-Ethnography Study Investigating Research and Care Implications

(2014) Maryam Hafsah Selamat et al.   PLoS One

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

(2013) Anilia Taliou et al.   CLINICAL THERAPEUTICS

Cancer ‘survivor-care’: II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment)

(2013) R. B. Raffa   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Chemobrain: A systematic review of structural and functional neuroimaging studies

(2013) Marta Simó et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Olive oil phenols and neuroprotection

(2013) Ali Reza Khalatbary   NUTRITIONAL NEUROSCIENCE

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

(2013) Shiqin Sun et al.   PLoS One

Opening up the Window into “Chemobrain”: A Neuroimaging Review

(2013) Carole Scherling et al.   SENSORS

Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy

(2012) L.-A. Christie et al.   CLINICAL CANCER RESEARCH

Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression

(2012) Daniela Silva Moura et al.   PLoS One

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

(2012) Bodi Zhang et al.   PLoS One

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

(2012) Konstantinos–Dionysios Alysandratos et al.   PLoS One

‘Chemobrain’: concentration and memory effects in people receiving chemotherapy - a descriptive phenomenological study

(2011) T. MITCHELL et al.   EUROPEAN JOURNAL OF CANCER CARE

Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells

(2011) Shahrzad Asadi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Flavonoids and the CNS

(2011) Anna Jäger et al.   MOLECULES

Mast cell activation syndrome: Proposed diagnostic criteria

(2010) Cem Akin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A proposed mechanism for chemotherapy-related cognitive impairment (‘chemo-fog’)

(2010) R. B. Raffa   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria

(2010) N. Dietrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

(2008) Kavon Rezai-Zadeh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin

(2008) Günter Seelinger et al.   PLANTA MEDICA

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

(2008) S. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA