Mast cells as sources of cytokines, chemokines, and growth factors

Are ILC2s Jekyll and Hyde in airway inflammation?

(2017) Kafi N. Ealey et al.   IMMUNOLOGICAL REVIEWS

IL-33 in clinical practice: Size matters?

(2017) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcriptional Heterogeneity of Mast Cells and Basophils upon Activation

(2017) Krishan D. Chhiba et al.   JOURNAL OF IMMUNOLOGY

TGF-β1 Suppresses IL-33–Induced Mast Cell Function

(2017) Victor S. Ndaw et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

(2017) Shomyseh Sanjabi et al.   Cold Spring Harbor Perspectives in Biology

Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B

(2017) M. Wroblewski et al.   Nature Communications

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

(2017) Silvia Moretti et al.   Nature Communications

Are Mast Cells MASTers in Cancer?

(2017) Gilda Varricchi et al.   Frontiers in Immunology

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics

(2016) Olga Schulz et al.   Annual Review of Immunology

Of Mouse Models of Mast Cell Deficiency and Metabolic Syndrome

(2016) Thorsten B. Feyerabend et al.   Cell Metabolism

Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders

(2016) Gilda Varricchi et al.   Current Opinion in Allergy and Clinical Immunology

A panoramic review and in silico analysis of IL-11 structure and function

(2016) Manica Negahdaripour et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma

(2016) Diego Bagnasco et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

(2016) Avanti Desai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current concepts of severe asthma

(2016) Anuradha Ray et al.   JOURNAL OF CLINICAL INVESTIGATION

Different activation signals induce distinct mast cell degranulation strategies

(2016) Nicolas Gaudenzio et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis

(2016) Chuan-Hui Kuo et al.   JOURNAL OF IMMUNOLOGY

Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure

(2016) Vladimir-Andrey Gimenez-Rivera et al.   JOURNAL OF IMMUNOLOGY

IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection

(2016) V S Pelly et al.   Mucosal Immunology

Discovery and initial characterization of Th9 cells: the early years

(2016) Edgar Schmitt et al.   Seminars in Immunopathology

Regulatory roles of mast cells in immune responses

(2016) Hideaki Morita et al.   Seminars in Immunopathology

Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

(2016) Carl-Fredrik Johnzon et al.   Frontiers in Immunology

Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases

(2015) A. Gela et al.   ALLERGY

Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance

(2015) Dario A. Gutierrez et al.   Cell Metabolism

Mast cell production and response to IL-4 and IL-13

(2015) Jamie J.A. McLeod et al.   CYTOKINE

Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy

(2015) Chun-Yu Chen et al.   IMMUNITY

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

TH9 cells are required for tissue mast cell accumulation during allergic inflammation

(2015) Sarita Sehra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory syncytial virus infection of primary human mast cells induces the selective production of type I interferons, CXCL10, and CCL4

(2015) Ayham Al-Afif et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database

(2015) Molly A. Bogue et al.   MAMMALIAN GENOME

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Group 2 Innate Lymphoid Cells in Health and Disease

(2015) Brian S. Kim et al.   Cold Spring Harbor Perspectives in Biology

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

(2015) Jan Dudeck et al.   Cell Reports

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Interferon-γ regulates growth and controls Fcγ receptor expression and activation in human intestinal mast cells

(2014) Gernot Sellge et al.   BMC IMMUNOLOGY

BCR-ABL-Induced Deregulation of the IL-33/ST2 Pathway in CD34(+) Progenitors from Chronic Myeloid Leukemia Patients

(2014) A. Levescot et al.   CANCER RESEARCH

Type-2 innate lymphoid cells in human allergic disease

(2014) Jillian L. Barlow et al.   Current Opinion in Allergy and Clinical Immunology

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

TGF- 1 Attenuates Mediator Release and De Novo Kit Expression by Human Skin Mast Cells through a Smad-Dependent Pathway

(2014) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

(2014) Tracy L. Putoczki et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

(2014) Laurent L. Reber et al.   Arthritis & Rheumatology

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells

(2013) D. B. Leveson-Gower et al.   BLOOD

Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection

(2013) Cheryl Y. Chan et al.   IMMUNITY

Interleukin-33 Synergistically Enhances Immune Complex-Induced Tumor Necrosis Factor Alpha and Interleukin-8 Production in Cultured Human Synovium-Derived Mast Cells

(2013) Jun-ichi Kashiwakura et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

(2013) Taylor A. Doherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

(2013) Ananya Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cell Fc RI-Induced Early Growth Response 2 Regulates CC Chemokine Ligand 1-Dependent CD4+ T Cell Migration

(2013) Z. Wu et al.   JOURNAL OF IMMUNOLOGY

Genotype-Dependent Effects of TGF- 1 on Mast Cell Function: Targeting the Stat5 Pathway

(2013) J. Fernando et al.   JOURNAL OF IMMUNOLOGY

Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction

(2013) Walid Beghdadi et al.   KIDNEY INTERNATIONAL

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

(2013) J. A. Nagy et al.   Cold Spring Harbor Perspectives in Medicine

Mast Cells: Potential Positive and Negative Roles in Tumor Biology

(2013) T. Marichal et al.   Cancer Immunology Research

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

(2012) M. Komai-Koma et al.   ALLERGY

The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis

(2012) Adrian M. Piliponsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

Mast cells play a protumorigenic role in primary cutaneous lymphoma

(2012) A. Rabenhorst et al.   BLOOD

Critical role of P1-Runx1 in mouse basophil development

(2012) K. Mukai et al.   BLOOD

Ten Years of the Collaborative Cross

(2012) David W. Threadgill et al.   GENETICS

Widespread Immunological Functions of Mast Cells: Fact or Fiction?

(2012) Hans-Reimer Rodewald et al.   IMMUNITY

Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Mutation in the Nlrp3 Protein

(2012) Yuumi Nakamura et al.   IMMUNITY

Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases

(2012) Toshio Tanaka et al.   International Journal of Biological Sciences

PDGF Enhances Orbital Fibroblast Responses to TSHR Stimulating Autoantibodies in Graves' Ophthalmopathy Patients

(2012) L. van Steensel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis

(2012) Y. T. Falanga et al.   JOURNAL OF IMMUNOLOGY

The Temporal and Spatial Dynamics of Foxp3+ Treg Cell–Mediated Suppression during Contact Hypersensitivity Responses in a Murine Model

(2012) Sari Lehtimäki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stem cell factor contributes to tumorigenesis of mast cells via an autocrine/paracrine mechanism

(2012) Y. Amagai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

(2012) Anatole Ghazalpour et al.   MAMMALIAN GENOME

Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation

(2012) I Waern et al.   Mucosal Immunology

New models for analyzing mast cell functions in vivo

(2012) Laurent L. Reber et al.   TRENDS IN IMMUNOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

(2011) J. N. Lilla et al.   BLOOD

Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

(2011) Alon Y. Hershko et al.   IMMUNITY

Mast Cells Condition Dendritic Cells to Mediate Allograft Tolerance

(2011) Victor C. de Vries et al.   IMMUNITY

Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

(2011) Anne Dudeck et al.   IMMUNITY

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

(2011) Thorsten B. Feyerabend et al.   IMMUNITY

Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis

(2011) Bodi Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma

(2011) Mang Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

MAPK Kinase 3 Specifically Regulates Fc RI-Mediated IL-4 Production by Mast Cells

(2011) A. J. MacNeil et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Enhance Mast Cell Production of IL-6 via Surface-Bound TGF- 

(2011) K. Ganeshan et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Interleukin-5 and IL-5 receptor in health and diseases

(2011) Kiyoshi TAKATSU   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

(2010) Jennifer Kearley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice

(2010) Hazuki Takato et al.   EXPERIMENTAL LUNG RESEARCH

IL-6: from its discovery to clinical applications

(2010) T. Kishimoto   INTERNATIONAL IMMUNOLOGY

Mast Cell-Derived IL-10 Suppresses Germinal Center Formation by Affecting T Follicular Helper Cell Function

(2010) R. Chacon-Salinas et al.   JOURNAL OF IMMUNOLOGY

IL-9 Production by Regulatory T Cells Recruits Mast Cells That Are Essential for Regulatory T Cell-Induced Immune Suppression

(2010) K. Eller et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-Mediated Mast Cell Activation Induces IFN-  Secretion by NK Cells

(2010) K. Vosskuhl et al.   JOURNAL OF IMMUNOLOGY

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-33 Is Produced by Mast Cells and Regulates IgE-Dependent Inflammation

(2010) Chia-Lin Hsu et al.   PLoS One

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

(2010) T. C. Theoharides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK1 controls mast cell degranulation and IL-1  production in inflammatory arthritis

(2010) M. Guma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 and IL-33 Receptors in Host Defense and Diseases

(2010) Keisuke Oboki et al.   ALLERGOLOGY INTERNATIONAL

Mast Cell-Derived TNF Can Exacerbate Mortality during Severe Bacterial Infections in C57BL/6-KitW-sh/W-sh Mice

(2009) Adrian M. Piliponsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung

(2009) Christina C. Lewis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

(2009) Aikaterini Detoraki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

(2009) Chien-hui Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

(2009) Yuumi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mast cell–derived particles deliver peripheral signals to remote lymph nodes

(2009) Christian A. Kunder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

(2009) T. Ohno et al.   JOURNAL OF IMMUNOLOGY

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

(2009) R. Madan et al.   JOURNAL OF IMMUNOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Mast Cells Regulate the Magnitude and the Cytokine Microenvironment of the Contact Hypersensitivity Response

(2008) M. Ursula Norman et al.   AMERICAN JOURNAL OF PATHOLOGY

Mast Cells Can Mediate Vascular Permeability through Regulation of the PI3K–HIF-1α–VEGF Axis

(2008) Kyung Sun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism

(2008) S. M. Burke et al.   BLOOD

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition

(2008) Arnold S Kirshenbaum et al.   BMC IMMUNOLOGY

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

(2008) Giorgia Gri et al.   IMMUNITY

IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity

(2008) Elizabeth E. Forbes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Chemokines and leukocyte traffic

(2008) Federica Sallusto et al.   NATURE IMMUNOLOGY

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology