Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice

(2020) Govindhasamy Pushpavathi Selvakumar et al.   BRAIN BEHAVIOR AND IMMUNITY

The Mast Cell Is an Early Activator of Lipopolysaccharide-Induced Neuroinflammation and Blood-Brain Barrier Dysfunction in the Hippocampus

(2020) Yiwei Wang et al.   MEDIATORS OF INFLAMMATION

Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

(2020) Xin Tan et al.   Frontiers in Pharmacology

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

(2020) Marika Cordaro et al.   Antioxidants

COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

(2020) Theoharis C. Theoharides   BIOFACTORS

Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats

(2020) RS Baty et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Luteolin and Apigenin Attenuate LPS-Induced Astrocyte Activation and Cytokine Production by Targeting MAPK, STAT3, and NF-κB Signaling Pathways

(2020) Denis Nchang Che et al.   INFLAMMATION

Promising Polyphenols in Parkinson’s Disease Therapeutics

(2020) Ashish Singh et al.   NEUROCHEMICAL RESEARCH

Management of Traumatic Brain Injury: From Present to Future

(2020) Rosalia Crupi et al.   Antioxidants

Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage

(2020) Yi Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s Disease

(2020) Camila Calfio et al.   JOURNAL OF ALZHEIMERS DISEASE

Flavonoids-mediated SIRT1 signaling activation in hepatic disorders

(2020) Ahmed M. Sayed et al.   LIFE SCIENCES

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

(2020) Duraisamy Kempuraj et al.   MEDIATORS OF INFLAMMATION

COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation

(2020) Duraisamy Kempuraj et al.   NEUROSCIENTIST

Neuroimmune System as a Driving Force for Plasticity Following CNS Injury

(2020) Micaela L. O’Reilly et al.   Frontiers in Cellular Neuroscience

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

Roles of flavonoids against coronavirus infection

(2020) Maria Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway

(2020) Shuwen Liu et al.   NEUROCHEMICAL RESEARCH

Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus

(2020) K. Chojnacka et al.   Journal of Functional Foods

Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

(2020) Václav Zima et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer’s Disease

(2019) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Mast Cells in Neurodegenerative Disease

(2019) Michael K. Jones et al.   Frontiers in Cellular Neuroscience

New insights on the disease contribution of neuroinflammation in amyotrophic lateral sclerosis

(2019) Aude Chiot et al.   CURRENT OPINION IN NEUROLOGY

Neuroprotection by Luteolin and Gallic acid against cobalt chloride-induced behavioural, morphological and neurochemical alterations in Wistar rats

(2019) A.S. Akinrinde et al.   NEUROTOXICOLOGY

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

(2019) Neil SN Graham et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent versus adult male mice

(2019) Fernanda Guilhaume‐Correa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin

(2019) Mona Abubakr Bawazeer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation

(2018) Zhao-Hui Yao et al.   NEUROCHEMICAL RESEARCH

Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson’s disease and inflammatory pathways

(2018) Zubeyir Elmazoglu et al.   DRUG AND CHEMICAL TOXICOLOGY

The Flavone Luteolin Improves Central Nervous System Disorders by Different Mechanisms: A Review

(2018) Zeinab Ashaari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases

(2018) Theoharis C. Theoharides et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

(2017) Stephen D. Skaper et al.   NEUROSCIENTIST

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

(2017) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration

(2017) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

Luteolin and Thiosalicylate Inhibit HGCL2 and Thimerosal-Induced VEGF Release from Human Mast Cells

(2017) S. Asadi et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Molecular targets of luteolin in cancer

(2016) Muobarak J. Tuorkey   EUROPEAN JOURNAL OF CANCER PREVENTION

Neuroprotective Effects of Co-UltraPEALut on Secondary Inflammatory Process and Autophagy Involved in Traumatic Brain Injury

(2016) Marika Cordaro et al.   JOURNAL OF NEUROTRAUMA

Role of dietary phenols in mitigating microglia-mediated neuroinflammation

(2016) Parakalan Rangarajan et al.   NEUROMOLECULAR MEDICINE

Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

(2015) Seyed Fazel Nabavi et al.   BRAIN RESEARCH BULLETIN

Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man

(2015) Carlo Caltagirone et al.   Translational Stroke Research

Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin

(2015) Theoharis C. Theoharides   Frontiers in Neuroscience

Posttraumatic administration of luteolin protects mice from traumatic brain injury: Implication of autophagy and inflammation

(2014) Jianguo Xu et al.   BRAIN RESEARCH

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

(2014) Jianguo Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic Neurodegeneration After Traumatic Brain Injury: Alzheimer Disease, Chronic Traumatic Encephalopathy, or Persistent Neuroinflammation?

(2014) Alan I. Faden et al.   Neurotherapeutics

Protective effects of luteolin on cognitive impairments induced by psychological stress in mice

(2013) Yi Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Traumatic brain injury, neuroimaging, and neurodegeneration

(2013) Erin D. Bigler   Frontiers in Human Neuroscience

Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia

(2012) Huimin Qiao et al.   BRAIN RESEARCH

Protective Effect of Luteolin in Experimental Ischemic Stroke: Upregulated SOD1, CAT, Bcl-2 and Claudin-5, Down-Regulated MDA and Bax Expression

(2012) Huimin Qiao et al.   NEUROCHEMICAL RESEARCH

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

(2011) Dae Kim et al.   Journal of Neuroinflammation

Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-κB-ERK-dependent pathway

(2011) Futao Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

(2010) D. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Distribution and Biological Activities of the Flavonoid Luteolin

(2009) Miguel Lopez-Lazaro   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

(2009) Yuxuan Jin et al.   STROKE

The flavonoid luteolin inhibits niacin-induced flush

(2008) D Papaliodis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells

(2008) D Kempuraj et al.   BRITISH JOURNAL OF PHARMACOLOGY

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

(2008) Han-Qing Chen et al.   NEUROSCIENCE LETTERS