Microtubule motors in centrosome homeostasis: A target for cancer therapy?

Cytoplasmic dynein-2 at a glance

(2020) Laura Vuolo et al.   JOURNAL OF CELL SCIENCE

PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?

(2019) Chiara Bazzichetto et al.   Cancers

Dynein activators and adaptors at a glance

(2019) Mara A. Olenick et al.   JOURNAL OF CELL SCIENCE

The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis

(2019) Devashish Dwivedi et al.   JOURNAL OF CELL BIOLOGY

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion

(2019) Marie Alice Dupont et al.   HUMAN MOLECULAR GENETICS

KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer

(2019) Yohei Sekino et al.   Journal of Clinical Medicine

Setting the dynein motor in motion: new insights from electron tomography

(2019) Danielle A. Grotjahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles

(2019) Nicolas Taulet et al.   Scientific Reports

Targeting centrosome amplification, an Achilles' heel of cancer

(2019) Dorota Sabat-Pośpiech et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

KIFC3 directs a centrosome cohesive force

(2019) Ciaran G. Morrison   NATURE CELL BIOLOGY

The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly

(2019) Shoji Hata et al.   NATURE CELL BIOLOGY

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains

(2019) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells

(2019) Naoaki Kurisawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells

(2018) MIN HO CHOE et al.   ANTICANCER RESEARCH

Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

(2018) Susana Eibes et al.   CURRENT BIOLOGY

Kinesin and Dynein Mechanics: Measurement Methods and Research Applications

(2018) Zachary Abraham et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

(2018) Ryan A. Denu et al.   MOLECULAR CANCER RESEARCH

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular characterization of the grape seeds extract’s effect against chemically induced liver cancer: In vivo and in vitro analyses

(2018) Alaaeldin Ahmed Hamza et al.   Scientific Reports

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

(2018) Guadalupe Sepulveda et al.   eLife

Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

(2018) Anthony J. Roberts   BIOCHEMICAL SOCIETY TRANSACTIONS

Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes

(2018) Megan E. Dumas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells

(2018) Ala’a Al-Hrout et al.   Scientific Reports

Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics

(2017) A J Lucanus et al.   ONCOGENE

PLK1, A Potential Target for Cancer Therapy

(2017) Zhixian Liu et al.   Translational Oncology

Ciliary Motility: Regulation of Axonemal Dynein Motors

(2017) Rasagnya Viswanadha et al.   Cold Spring Harbor Perspectives in Biology

C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma

(2017) Yu-Xi Xiao et al.   Oncotarget

The Role of Chromosomal Instability in Cancer and Therapeutic Responses

(2017) Natalia Vargas-Rondón et al.   Cancers

Discovery of a novel inhibitor of kinesin-like protein KIFC1

(2016) W. Zhang et al.   BIOCHEMICAL JOURNAL

Review: Structure and mechanism of the dynein motor ATPase

(2016) Helgo Schmidt et al.   BIOPOLYMERS

BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein

(2016) Sadiya Malik et al.   CELL CYCLE

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

(2016) Roy G. H. P. van Heesbeen et al.   CHROMOSOMA

Centrosomal clustering contributes to chromosomal instability and cancer

(2016) A Milunović-Jevtić et al.   CURRENT OPINION IN BIOTECHNOLOGY

How dynein and dynactin transport cargos: a structural perspective

(2016) Andrew P Carter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

BRCA2 functions: from DNA repair to replication fork stabilization

(2016) Amélie Fradet-Turcotte et al.   ENDOCRINE-RELATED CANCER

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

(2016) Janine H. van Ree et al.   NATURE CELL BIOLOGY

Axoneme Structure from Motile Cilia

(2016) Takashi Ishikawa   Cold Spring Harbor Perspectives in Biology

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

(2016) Pavithra L. Chavali et al.   Nature Communications

A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas

(2016) Karuna Mittal et al.   Journal of Ovarian Research

Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells

(2016) Alaaeldin Ahmed Hamza et al.   PLoS One

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

KIFC1 is a novel potential therapeutic target for breast cancer

(2015) Yonghe Li et al.   CANCER BIOLOGY & THERAPY

Centrosomes are multifunctional regulators of genome stability

(2015) Dorothy A. Lerit et al.   CHROMOSOME RESEARCH

Centrosomes in spindle organization and chromosome segregation: a mechanistic view

(2015) Patrick Meraldi   CHROMOSOME RESEARCH

TPX2

(2015) Pat Wadsworth   CURRENT BIOLOGY

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Dis-organizing Centrosomal Clusters: Specific Cancer Therapy for a Generic Spread?

(2015) D. Bhakta-Guha et al.   CURRENT MEDICINAL CHEMISTRY

Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

(2015) Nobutaka Hirokawa et al.   EXPERIMENTAL CELL RESEARCH

Dynein and intraflagellar transport

(2015) Yuqing Hou et al.   EXPERIMENTAL CELL RESEARCH

Cell Cycle-Dependent Localization of Dynactin Subunit p150gluedat Centrosome

(2015) Ting-Yu Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase

(2015) Mi Young Seo et al.   PLoS One

Designing a broad-spectrum integrative approach for cancer prevention and treatment

(2015) Keith I. Block et al.   SEMINARS IN CANCER BIOLOGY

The Centrosome and Its Duplication Cycle

(2015) Jingyan Fu et al.   Cold Spring Harbor Perspectives in Biology

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

(2015) Vaishali Pannu et al.   Oncotarget

Journey to the Center of the Centrosome

(2014) Tim Stearns   DEVELOPMENTAL CELL

Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion

(2014) Laura A. Jones et al.   JOURNAL OF CELL BIOLOGY

Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction

(2014) T. Hardy et al.   JOURNAL OF CELL SCIENCE

SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis

(2014) Jia Li et al.   JOURNAL OF PATHOLOGY

Separate to operate: control of centrosome positioning and separation

(2014) F. G. Agircan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Centriole structure

(2014) M. Winey et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pericentriolar material structure and dynamics

(2014) J. B. Woodruff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells

(2014) V Pannu et al.   Cell Death & Disease

APC/C is an essential regulator of centrosome clustering

(2014) Konstantinos Drosopoulos et al.   Nature Communications

KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries

(2014) Shrikant Pawar et al.   Journal of Ovarian Research

SUN proteins and nuclear envelope spacing

(2014) Natalie E Cain et al.   Nucleus

Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1

(2013) Jiaquan Wu et al.   ACS Chemical Biology

Association of nucleus and centrosome: magnet or velcro?

(2013) Anton V. Burakov et al.   CELL BIOLOGY INTERNATIONAL

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

(2013) Ciorsdaidh A. Watts et al.   CHEMISTRY & BIOLOGY

Nesprins: from the nuclear envelope and beyond

(2013) Dipen Rajgor et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Big steps toward understanding dynein

(2013) Masahide Kikkawa   JOURNAL OF CELL BIOLOGY

Functions and mechanics of dynein motor proteins

(2013) Anthony J. Roberts et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytoplasmic dynein

(2012) Victoria J. Allan   BIOCHEMICAL SOCIETY TRANSACTIONS

Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration

(2012) Angela Ogden et al.   CANCER AND METASTASIS REVIEWS

C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis

(2012) Pauline C. Conroy et al.   CELL CYCLE

Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy

(2012) A Ogden et al.   CELL DEATH AND DIFFERENTIATION

Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification

(2012) Christopher W. Brownlee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

IntroducingCichorium Pumilumas a Potential Therapeutical Agent Against Drug-Induced Benign Breast Tumor in Rats

(2012) M-Ali H. Al-Akhras et al.   ELECTROMAGNETIC BIOLOGY AND MEDICINE

Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation

(2012) Jonne A Raaijmakers et al.   EMBO JOURNAL

The centriolar satellite protein Cep131 is important for genome stability

(2012) C. J. Staples et al.   JOURNAL OF CELL SCIENCE

Never tear us apart - the importance of centrosome clustering

(2012) V. Marthiens et al.   JOURNAL OF CELL SCIENCE

The where, when and how of microtubule nucleation - one ring to rule them all

(2012) N. Teixido-Travesa et al.   JOURNAL OF CELL SCIENCE

Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry

(2012) Jeanne N. Jodoin et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple modes of cytoplasmic dynein regulation

(2012) Richard B. Vallee et al.   NATURE CELL BIOLOGY

The mechanism of dynein motility: Insight from crystal structures of the motor domain

(2011) Carol Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly

(2011) Jorge Z. Torres et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CEP215 is involved in the dynein-dependent accumulation of pericentriolar matrix proteins for spindle pole formation

(2011) Seongju Lee et al.   CELL CYCLE

The centrosome and bipolar spindle assembly

(2011) Edward H. Hinchcliffe   CELL CYCLE

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

(2011) M Teresa Bertran et al.   EMBO JOURNAL

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

Centrosome clustering and chromosomal (in)stability: A matter of life and death

(2011) Alwin Krämer et al.   Molecular Oncology

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cohesin: It’s not just for chromosomes anymore

(2010) Laura A. Simmons Kovacs et al.   CELL CYCLE

Centriole duplication

(2010) Andrew J. Holland et al.   CELL CYCLE

Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope

(2010) Maria Schneider et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of Centrosome Separation and Bipolar Spindle Assembly

(2010) Marvin E. Tanenbaum et al.   DEVELOPMENTAL CELL

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

The nuclear envelope at a glance

(2010) K. L. Wilson et al.   JOURNAL OF CELL SCIENCE

Proteins Required for Centrosome Clustering in Cancer Cells

(2010) B. Leber et al.   Science Translational Medicine

The Nuclear Envelope

(2010) M. W. Hetzer   Cold Spring Harbor Perspectives in Biology

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly

(2009) Marvin E. Tanenbaum et al.   CURRENT BIOLOGY

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of kinesin motor proteins

(2009) Alexander Marx et al.   CELL MOTILITY AND THE CYTOSKELETON

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Multiple centrosomes: together they stand, divided they fall

(2008) F. Gergely et al.   GENES & DEVELOPMENT

The mammalian centrosome and its functional significance

(2008) Heide Schatten   HISTOCHEMISTRY AND CELL BIOLOGY

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

(2008) J. Rapley et al.   JOURNAL OF CELL SCIENCE

The AAA+ superfamily of functionally diverse proteins

(2008) Jamie Snider et al.   GENOME BIOLOGY

CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex

(2007) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL