Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells

(2011) Asher Castiel et al.   BMC CANCER

Beyond focal adhesions: Integrin linked kinase associates with tubulin and regulates mitotic spindle organization

(2011) Andrew B. Fielding et al.   CELL CYCLE

Anaphase Catastrophe Is a Target for Cancer Therapy

(2011) Fabrizio Galimberti et al.   CLINICAL CANCER RESEARCH

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

(2011) Lis Jakobsen et al.   EMBO JOURNAL

The conversion of centrioles to centrosomes: essential coupling of duplication with segregation

(2011) Won-Jing Wang et al.   JOURNAL OF CELL BIOLOGY

Comparative analysis of pre-replication complex proteins in transformed and normal cells

(2011) Domenic Di Paola et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients

(2011) Tatsuya Kato et al.   LUNG CANCER

Centrosome clustering and chromosomal (in)stability: A matter of life and death

(2011) Alwin Krämer et al.   Molecular Oncology

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Cleavage of cohesin rings coordinates the separation of centrioles and chromatids

(2011) Laura Schöckel et al.   NATURE CELL BIOLOGY

Actomyosin-Dependent Cortical Dynamics Contributes to the Prophase Force-Balance in the Early Drosophila Embryo

(2011) Patrizia Sommi et al.   PLoS One

Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia

(2011) M. Lehtinen et al.   SEXUALLY TRANSMITTED INFECTIONS

Chlamydia trachomatis Infection Causes Mitotic Spindle Pole Defects Independently from its Effects on Centrosome Amplification

(2011) Andrea E. Knowlton et al.   TRAFFIC

Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma

(2010) LING YU et al.   APMIS

Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine

(2010) Krishnan Rathinasamy et al.   BMC CANCER

Centriole duplication: analogue control in a digital age

(2010) Greenfield Sluder et al.   CELL BIOLOGY INTERNATIONAL

Cohesin is needed for bipolar mitosis in human cells

(2010) Laura A. Díaz-Martínez et al.   CELL CYCLE

Cohesin: It’s not just for chromosomes anymore

(2010) Laura A. Simmons Kovacs et al.   CELL CYCLE

Determinants of Rad21 localization at the centrosome in human cells

(2010) Juan F. Giménez-Abián et al.   CELL CYCLE

An update on cohesin function as a ‘molecular glue’ on chromosomes and spindles

(2010) Richard W. Wong   CELL CYCLE

Rad21 is required for centrosome integrity in human cells independently of its role in chromosome cohesion

(2010) Nicole A. Beauchene et al.   CELL CYCLE

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

(2010) P Karna et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Mechanisms of force generation by end-on kinetochore-microtubule attachments

(2010) Ajit P Joglekar et al.   CURRENT OPINION IN CELL BIOLOGY

The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication

(2010) R. L. Ferguson et al.   JOURNAL OF CELL SCIENCE

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Tubulin depolymerization may be an ancient biological motor

(2010) J. R. McIntosh et al.   JOURNAL OF CELL SCIENCE

Ric-8A and Gi  Recruit LGN, NuMA, and Dynein to the Cell Cortex To Help Orient the Mitotic Spindle

(2010) G. E. Woodard et al.   MOLECULAR AND CELLULAR BIOLOGY

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

(2010) A B Fielding et al.   ONCOGENE

Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention

(2010) Travis L. Schmit et al.   PHARMACEUTICAL RESEARCH

Proteins Required for Centrosome Clustering in Cancer Cells

(2010) B. Leber et al.   Science Translational Medicine

Dynein at the kinetochore: Timing, Interactions and Functions

(2010) Jason R. Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

(2010) Astrid Guerrero et al.   Cell Division

MAD2 as a Key Component of Mitotic Checkpoint

(2009) Li Wang et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

Overexpression and Mislocalization of the Chromosomal Segregation Protein Separase in Multiple Human Cancers

(2009) R. Meyer et al.   CLINICAL CANCER RESEARCH

Force and Length in the Mitotic Spindle

(2009) Sophie Dumont et al.   CURRENT BIOLOGY

Sister chromatid tension and the spindle assembly checkpoint

(2009) Luigi Nezi et al.   CURRENT OPINION IN CELL BIOLOGY

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells

(2009) Michael J. Difilippantonio et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Aurora A, centrosome structure, and the centrosome cycle

(2009) Kara B. Lukasiewicz et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement

(2009) Akito Nakamura et al.   JOURNAL OF CELL BIOLOGY

9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells

(2009) Aruna S. Jaiswal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia

(2009) Nicole den Elzen et al.   MOLECULAR BIOLOGY OF THE CELL

Ab ovo or de novo? Mechanisms of centriole duplication

(2009) Jadranka Loncarek et al.   MOLECULES AND CELLS

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells

(2009) H Izumi et al.   ONCOGENE

Plk1-Dependent Recruitment of γ-Tubulin Complexes to Mitotic Centrosomes Involves Multiple PCM Components

(2009) Laurence Haren et al.   PLoS One

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Orc1 Controls Centriole and Centrosome Copy Number in Human Cells

(2009) A. S. Hemerly et al.   SCIENCE

Function of dynein in budding yeast: Mitotic spindle positioning in a polarized cell

(2009) Jeffrey K. Moore et al.   CELL MOTILITY AND THE CYTOSKELETON

Delocalization of the Microtubule Motor Dynein from Mitotic Spindles by the Human Papillomavirus E7 Oncoprotein Is Not Sufficient for Induction of Multipolar Mitoses

(2008) Christine L. Nguyen et al.   CANCER RESEARCH

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Mitotic Checkpoint Genes, hsMAD2 and BubR1, in Oesophageal Squamous Cancer Cells and their Association with 5-fluorouracil and Cisplatin-based Radiochemotherapy

(2008) K. Tanaka et al.   CLINICAL ONCOLOGY

sSgo1, a Major Splice Variant of Sgo1, Functions in Centriole Cohesion Where It Is Regulated by Plk1

(2008) Xiaoxing Wang et al.   DEVELOPMENTAL CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Clinicopathologic significance of mitotic arrest defective protein 2 overexpression in hepatocellular carcinoma

(2008) Shu-Hui Zhang et al.   HUMAN PATHOLOGY

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

(2008) Andrew B. Fielding et al.   JOURNAL OF CELL BIOLOGY

Cyclin E-dependent localization of MCM5 regulates centrosome duplication

(2008) R. L. Ferguson et al.   JOURNAL OF CELL SCIENCE

MCAK-Independent Functions of ch-Tog/XMAP215 in Microtubule Plus-End Dynamics

(2008) A. R. Barr et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules

(2008) Shang Cai et al.   MOLECULAR BIOLOGY OF THE CELL

Breaking the ties that bind centriole numbers

(2008) Jeffrey L. Salisbury   NATURE CELL BIOLOGY

Control of daughter centriole formation by the pericentriolar material

(2008) Jadranka Loncarek et al.   NATURE CELL BIOLOGY

The 3Ms of central spindle assembly: microtubules, motors and MAPs

(2008) Michael Glotzer   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aberrant MAD2 expression in soft-tissue sarcoma

(2008) Masanori Hisaoka et al.   PATHOLOGY INTERNATIONAL

Mechanisms of procentriole formation

(2008) Petr Strnad et al.   TRENDS IN CELL BIOLOGY

The TACC proteins: TACC-ling microtubule dynamics and centrosome function

(2008) Isabel Peset et al.   TRENDS IN CELL BIOLOGY

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS