Review
Pharmacology & Pharmacy
Jun Zhang, Yu Xia, Xiaomei Zhou, Honghao Yu, Yufang Tan, Yaying Du, Qi Zhang, Yiping Wu
Summary: Triple-negative breast cancer is a highly malignant subtype of breast cancer with aggressive behaviors. It is associated with poor clinical outcomes, early recurrence, and a higher likelihood of visceral metastases compared to other types of breast cancer. Personalized or combined therapies based on molecular heterogeneity are showing promising results in treating triple-negative breast cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Sylvie Rodrigues-Ferreira, Clara Nahmias
Summary: Breast cancer is a common malignancy among women worldwide, and different treatment options have significantly improved patient outcomes. However, further research on predictive biomarkers is needed to combat treatment resistance and identify the most suitable patients for personalized treatment, aiming to avoid unnecessary overtreatment.
Review
Medicine, Research & Experimental
Elisa Martino, Nunzia D'Onofrio, Camilla Anastasio, Marianna Abate, Silvia Zappavigna, Michele Caraglia, Maria Luisa Balestrieri
Summary: Micro-RNAs (miRNAs) play dual roles as oncogenes and tumor suppressors in carcinogenesis by controlling gene expression at the posttranscriptional level. The off-target effect of miRNAs limits their potential therapeutic use, but encapsulating them in nanostructured carriers enables targeted destruction of cancer cells without harming healthy tissues. Nanoparticles (NPs) with their small size and optimal surface/size ratio can encapsulate, protect, and release miRNAs, providing a promising strategy for cancer treatment. This review discusses the latest advances in miRNA-encapsulating NPs for cancer therapy, with a focus on colorectal cancer and its metastatic forms, which are among the most common malignancies worldwide.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Oncology
Miao Su, Zhe Zhang, Li Zhou, Chao Han, Canhua Huang, Edouard C. Nice
Summary: Cancer is a major global public health issue and personalized/precision medicine plays a crucial role in its diagnosis and treatment. Research focuses on cancer biomarkers, the impact of the microbiome, the application of emerging omics technologies, and future prospects.
Review
Oncology
Simona-Ruxandra Volovat, Iolanda Augustin, Daniela Zob, Diana Boboc, Florin Amurariti, Constantin Volovat, Cipriana Stefanescu, Cati Raluca Stolniceanu, Manuela Ciocoiu, Eduard Alexandru Dumitras, Mihai Danciu, Delia Gabriela Ciobanu Apostol, Vasile Drug, Sinziana Al Shurbaji, Lucia-Georgiana Coca, Florin Leon, Adrian Iftene, Paul-Corneliu Herghelegiu
Summary: This article provides an overview of the molecular classification of colorectal cancer and its relationship with epigenetic alterations. It also discusses the identification of prognostic and predictive biomarkers in metastatic colorectal cancer. The composition of the intestinal microbiota is found to be an important biomarker for the response to immune-based therapy in colorectal cancer. Additionally, the use of artificial intelligence technology can enhance the identification of biomarkers.
Review
Biochemistry & Molecular Biology
Zaoqu Liu, Jinxiang Lv, Qin Dang, Long Liu, Siyuan Weng, Libo Wang, Zhaokai Zhou, Ying Kong, Huanyun Li, Yilin Han, Xinwei Han
Summary: Immunotherapy treatments using the immune system have revolutionized personalized medicine and brought significant benefits for cancer patients. Tumor neoantigens, arising from somatic mutations and presented by major histocompatibility complex, play a crucial role in immunotherapy. With advancements in sequencing technology and bioinformatics, the identification of neoantigens has accelerated and is expected to be integrated into clinical practice. Neoantigen vaccines, such as peptides, DNA, RNA, and dendritic cells, have shown great potential in activating specific T cells and enhancing anti-tumor immunity. This review discusses the origin and prediction of neoantigens, compares different types of neoantigen vaccines, and explores strategies for improving their efficacy, while addressing the challenges in their application.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer Srivastava
Summary: Molecular subtypes-based therapies provide a new potential framework for precise outcomes in clinical settings, as colorectal cancer is a highly heterogeneous malignancy with different pathological and genetic signatures in each subtype. Designing therapeutic stratification based on these features may lead to improved treatment outcomes.
Review
Oncology
Himali Gujrati, Siyoung Ha, Bi-Dar Wang
Summary: This article systematically reviews the roles of microRNAs in the development and progression of prostate cancer. It highlights the current understanding and knowledge gap related to the deregulation of microRNAs in prostate cancer diseases, as well as summarizes the progress on the development of microRNA-based diagnostic/prognostic biomarkers and therapies for prostate cancer.
Review
Biochemistry & Molecular Biology
Fangyoumin Feng, Bihan Shen, Xiaoqin Mou, Yixue Li, Hong Li
Summary: The response rate of most anti-cancer drugs is limited due to cancer heterogeneity and complex drug mechanisms. Personalized treatment using molecular biomarkers shows promise. Advances in pharmacogenomics, especially computational methods in drug response prediction, have been successful and increasingly utilized in personalized cancer medicine.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Biochemical Research Methods
Vu V. H. Pham, Lin Liu, Cameron P. Bracken, Thin Nguyen, Gregory J. Goodall, Jiuyong Li, Thuc D. Le
Summary: Unraveling cancer driver genes is crucial in cancer research, with a need to identify individual-level drivers (both coding and miRNA). The proposed pDriver method showed superior effectiveness in detecting personalized cancer drivers in five TCGA cancer datasets, including miRNA drivers.
Article
Oncology
Haihua Huang, Zhentian Kai, Yuchen Wang, Xiaomiao Zhang, Jin Wang, Wei Zhang, Qian Xue, Hang Zhang, Hansong Jin, Peize Meng, Shuilong Zhang, Yueyue Yang, Honghua Yang, Wanning Liang, Guangbing Zha, Peng Luo, Yan Xu, Weiwei Shi, Zheng Ruan
Summary: In this study, we evaluated factors influencing the detection sensitivity of circulating tumor DNA (ctDNA) and found that histological subtypes and disease stages played significant roles in ctDNA detection rate. Additionally, we discovered that DNA extracted from bronchoalveolar lavage fluid had higher levels of ctDNA compared to plasma, suggesting its potential as a valuable sample source for tumor detection. Furthermore, tumor cellularity was shown to have a significant impact on the design of personalized ctDNA panels and the overall detection sensitivity.
Article
Oncology
Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang, Anton Buzdin
Summary: RNA sequencing analysis of tumor FFPE materials may be helpful for personalizing prescriptions of targeted therapeutics in CRC. The Oncobox drug efficiency score is an effective biomarker that can predict treatment outcomes, especially for bevacizumab.
Review
Cell Biology
Vincenza Conteduca, Alessandra Mosca, Nicole Brighi, Ugo de Giorgi, Pasquale Rescigno
Summary: Prostate cancer is a common cancer in men and patients may develop metastatic disease after radical treatments. Prognostic biomarkers are urgently needed to define patients' risk of cancer-related death.
Review
Pharmacology & Pharmacy
Zaid Sirhan, Rawan Alojair, Anita Thyagarajan, Ravi P. Sahu
Summary: Lung cancer is a major malignancy globally, with NSCLC being the most common type. PTEN, a tumor suppressor gene, plays a critical role in regulating cancer growth and its dysfunction is associated with poor prognosis in lung cancer patients. PTEN has been explored as a promising target for anti-cancer agents, as it can interact with multiple signaling pathways to devise effective treatment options for NSCLC.
Review
Biochemistry & Molecular Biology
Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Durairaj Sekar
Summary: Cancer is a global threat and current therapeutics lack specificity and have side effects. Researchers have been studying the PTEN/PI3K/AKT pathway and microRNAs as potential targets for novel cancer therapeutics. This review focuses on the role of miRNAs in regulating the PTEN/PI3K/AKT axis in various cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Rossella Loria, Valentina Laquintana, Stefano Scalera, Rocco Fraioli, Valentina Caprara, Italia Falcone, Chiara Bazzichetto, Marta Di Martile, Laura Rosano, Donatella Del Bufalo, Gianluca Bossi, Isabella Sperduti, Irene Terrenato, Paolo Visca, Silvia Soddu, Michele Milella, Gennaro Ciliberto, Rita Falcioni, Virginia Ferraresi, Giulia Bon
Summary: This study reveals that high expression of SEMA6A is associated with poor prognosis in BRAF-mutant melanoma and plays a critical role in promoting tumor aggressiveness and resistance to targeted therapies. SEMA6A may serve as a potential predictor for the efficacy of dual BRAF/MEK inhibition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Michele Milella
Summary: Soluble factors produced by stromal fibroblasts can influence the sensitivity of tumor cells to molecularly targeted drugs. This influence depends on the genetic mutations and PTEN protein status of the tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chiara Bazzichetto, Michele Milella, Ilaria Zampiva, Francesca Simionato, Carla Azzurra Amoreo, Simonetta Buglioni, Chiara Pacelli, Loredana Le Pera, Teresa Colombo, Emilio Bria, Massimo Zeuli, Donatella Del Bufalo, Isabella Sperduti, Fabiana Conciatori
Summary: Interleukin-8 (IL-8) plays an important role in colorectal cancer and its high levels are significantly correlated with shorter overall survival and progression-free survival. Circulating IL-8 represents an important prognostic factor in colorectal cancer.
Article
Biochemistry & Molecular Biology
Claudia Contadini, Alessandra Ferri, Marta Di Martile, Claudia Cirotti, Donatella Del Bufalo, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Francesca Sacco, Gloria Donninelli, Alessia Capone, Elisabetta Volpe, Nadine Keller, Shunichiro Miki, Daisuke Kawauchi, Dwayne Stupack, Frank Furnari, Daniela Barila
Summary: Caspase-8 is involved in apoptosis, but its expression is often downregulated in cancer cells. This study found that the activated Src tyrosine kinase in cancer cells can phosphorylate Caspase-8, inhibiting its activity and promoting tumor growth through the activation of the NF kappa B signaling pathway.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Antonino Guerrisi, Italia Falcone, Fabio Valenti, Marco Rao, Enzo Gallo, Sara Ungania, Maria Teresa Maccallini, Maurizio Fanciulli, Pasquale Frascione, Aldo Morrone, Mauro Caterino
Summary: Artificial intelligence is increasingly being used in the field of medicine, particularly in the treatment of cancer. By processing large amounts of data, AI can assist clinicians in making more accurate treatment decisions, improving patient outcomes.
Review
Biochemistry & Molecular Biology
Elena Ricciardi, Elena Giordani, Giovanna Ziccheddu, Italia Falcone, Patrizio Giacomini, Maurizio Fanciulli, Michelangelo Russillo, Marianna Cerro, Gennaro Ciliberto, Aldo Morrone, Antonino Guerrisi, Fabio Valenti
Summary: Precision medicine has brought about a major change in the treatment of cancer, focusing on the individual and unique characteristics of each patient and tumor. Liquid biopsy, through the analysis of molecules and biomarkers in the blood, presents new opportunities in personalized medicine. Its easy application and lack of contraindications make it applicable in various fields. This review explores the applications and potential developments of liquid biopsy in metastatic melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elisabetta Valentini, Marta Di Martile, Matteo Brignone, Marica Di Caprio, Isabella Manni, Michela Chiappa, Ilaria Sergio, Martina Chiacchiarini, Chiara Bazzichetto, Fabiana Conciatori, Simona D'Aguanno, Carmen D'Angelo, Rino Ragno, Michelangelo Russillo, Gianni Colotti, Francesco Marchesi, Maria Laura Bellone, Fabrizio Dal Piaz, Maria Pia Felli, Giovanna Damia, Donatella Del Bufalo
Summary: BH3 mimetics, which target the anti-apoptotic proteins of the Bcl-2 family, have shown promising therapeutic potential in cancer treatment. IS21, a novel pan BH3 mimetic, has been found to have preclinical antitumor activity in various types of tumors. IS21 demonstrated activity in T-cell acute lymphoblastic leukemia, melanoma, lung, pancreatic, and ovarian cancer cell lines.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Eriseld Krasniqi, Frauke Goeman, Claudio Pulito, Alina Catalina Palcau, Ludovica Ciuffreda, Francesca Sofia Di Lisa, Lorena Filomeno, Maddalena Barba, Laura Pizzuti, Federico Cappuzzo, Giuseppe Sanguineti, Marcello Maugeri-Sacca, Gennaro Ciliberto, Maurizio Fanciulli, Giovanni Blandino, Patrizia Vici
Summary: This review summarizes the mechanisms of resistance to CDK4/6 inhibitors in breast cancer cells and focuses on potential biomarkers that could predict patients' response/resistance to treatment. Recent advances in biomarker identification, including the use of liquid biopsy and multiple microRNAs, are also discussed in the context of breast cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sara Donzelli, Ludovica Ciuffreda, Martina Pontone, Martina Betti, Alice Massacci, Carla Mottini, Francesca De Nicola, Giulia Orlandi, Frauke Goeman, Eugenia Giuliani, Eleonora Sperandio, Giulia Piaggio, Aldo Morrone, Gennaro Ciliberto, Maurizio Fanciulli, Giovanni Blandino, Fulvia Pimpinelli, Matteo Pallocca
Summary: Tracking SARS-CoV-2 variants of concern via whole genome sequencing is crucial for containing the pandemic, as it provides insights into immune escape and aids in implementing interventions. However, NGS laboratories worldwide face challenges in processing large numbers of swabs efficiently.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
