Article
Multidisciplinary Sciences
Yainyrette Rivera-Rivera, Mihaela Marina, Shirley Jusino, Miyoung Lee, Jaleisha Velez Velazquez, Camille Chardon-Colon, Geraldine Vargas, Jaya Padmanabhan, Srikumar P. Chellappan, Harold I. Saavedra
Summary: Nek2 overexpression plays a crucial role in the occurrence and progression of breast cancer, leading to CA/CIN and EMT, and promoting invasion and migration through a mechanism mediated by Slug and Zeb1.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Multidisciplinary Sciences
Craig M. Bielski, Barry S. Taylor
Summary: Genomic instability is a characteristic of cancer, but exploiting this feature to selectively target cancer cells remains a major challenge in cancer biology with significant implications for drug development.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Batuhan Mert Kalkan, Selahattin Can Ozcan, Nicholas J. Quintyne, Samantha L. Reed, Ceyda Acilan
Summary: This article reviews the causes and consequences of centrosome amplification, revealing its close relationship with chromosomal instability and the formation and progression of cancer. While centrosome amplification may provide proliferative advantages, it can also lead to loss of genetic material and cancer cells must cope with these deadly consequences.
Review
Biochemistry & Molecular Biology
Ahmed Malki, Rasha Abu ElRuz, Ishita Gupta, Asma Allouch, Semir Vranic, Ala-Eddin Al Moustafa
Summary: Colorectal cancer is the second leading cause of cancer-related mortality rates worldwide, with its prevalence still on the rise. Dysregulation of several cellular signaling pathways in CRC leads to malignant phenotypes. Studying signaling pathways helps elucidate the mechanisms of CRC progression and pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Juliann Shih, Shahab Sarmashghi, Nadja Zhakula-Kostadinova, Shu Zhang, Yohanna Georgis, Stephanie H. Hoyt, Michael S. S. Cuoco, Galen F. F. Gao, Liam F. F. Spurr, Ashton C. C. Berger, Gavin Ha, Veronica Rendo, Hui Shen, Matthew Meyerson, Andrew D. D. Cherniack, Alison M. M. Taylor, Rameen Beroukhim
Summary: A method called BISCUT was developed to identify loci with fitness advantages or disadvantages by analyzing length distributions of telomere- or centromere-bounded copy-number events. These loci were enriched for known cancer driver genes and often specific to certain cell lineages. The study also found that the impact of copy-number alterations on cellular fitness is highly correlated with the frequency of whole-chromosome or whole-arm imbalances.
Article
Immunology
Qing Peng, Tingyu Wen, Dongyang Liu, Suguo Wang, Xinting Jiang, Shiju Zhao, Gaozhong Huang
Summary: This study comprehensively analyzed DSN1 expression in different molecular subtypes or stages of breast cancer, and found that upregulation of DSN1 was strongly associated with poor prognosis and decreased survival in breast cancer. Significant differences in DSN1 expression were also observed in different pathological subtypes and stages of breast cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Maria Rosito, Caterina Sanchini, Giorgio Gosti, Manuela Moreno, Simone De Panfilis, Maria Giubettini, Doriana Debellis, Federico Catalano, Giovanna Peruzzi, Roberto Marotta, Alessia Indrieri, Elvira De Leonibus, Maria Egle De Stefano, Davide Ragozzino, Giancarlo Ruocco, Silvia Di Angelantonio, Francesca Bartolini
Summary: Activated microglia undergo a remodeling of the microtubule cytoskeleton, transitioning from a non-centrosomal array of parallel and stable microtubules to a radial array of more dynamic microtubules. Microtubule nucleation occurs at Golgi outposts in the homeostatic state, while activation signaling recruits nucleating material nearby the centrosome, a process inhibited by microtubule stabilization.
Article
Oncology
Xiaoxiao Zhang, Maik Kschischo
Summary: This article examines chromosomal instability in cancer cells and compares the differences between whole chromosome instability (W-CIN) and structural chromosomal instability (S-CIN). The study finds that W-CIN is linked to whole genome doubling (WGD), while S-CIN is associated with a specific DNA damage repair pathway. Targeting both types of instability using current compounds is challenging, and they have distinct prognostic values.
Article
Oncology
Tiziana Monteverde, Sudhakar Sahoo, Manuela La Montagna, Peter Magee, Lei Shi, Dave Lee, Robert Sellers, Alexander R. Baker, Hui Sun Leong, Matteo Fassan, Michela Garofalo
Summary: CKAP2L has been identified as a potential oncogene that promotes lung cancer proliferation by directly interacting with RNA Pol II to regulate transcription elongation of key genes involved in various cellular pathways. Inhibiting CKAP2L could enhance therapeutic response in patients with NSCLC by increasing sensitivity to specific inhibitors and reducing cell proliferation.
Article
Biochemistry & Molecular Biology
Qin Huo, Siqi Chen, Jialang Zhuang, Chuntao Quan, Yue Wang, Ni Xie
Summary: This study demonstrates that the interaction between SIRT7 and LAP2 alpha plays a critical role in regulating chromosomal instability (CIN) and metastasis in breast cancer. The loss of SIRT7 leads to CIN in breast cancer cells, while degradation of LAP2 alpha also increases CIN in breast cancer cells. Furthermore, in vitro and in vivo experiments confirmed that SIRT7 promotes breast cancer metastasis through the SIRT7/LAP2 alpha axis. Inhibition of the SIRT7/LAP2 alpha axis may represent a potential therapeutic strategy for preventing breast cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ming Du, Shuo Zhang, Xiaoxia Liu, Congjian Xu, Xiaoyan Zhang
Summary: This article reviews the survival stresses and adaptive tolerances within nondiploid cancer cells and summarizes potential therapeutic ploidy-selective alterations, providing insights for the development of future cancer therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Editorial Material
Genetics & Heredity
Gwenola Manic, Lorenzo Galluzzi, Ilio Vitale
Summary: Unscheduled tetraploidy, a meta-stable state, quickly develops into aneuploidy. Freshly formed tetraploid cells fail to accumulate necessary DNA replication factors after whole-genome duplication (WGD) during the first G1 phase, resulting in genetic instability and extensive karyotypic alterations during the subsequent S phase.
TRENDS IN GENETICS
(2022)
Article
Oncology
I Lodewijk, A. Bernardini, C. Suarez-Cabrera, E. Bernal, R. Sanchez, J. L. Garcia, K. Rojas, L. Morales, S. Wang, X. Han, M. Duenas, J. M. Paramio, L. Manso
Summary: In patients with ovarian cancer undergoing neoadjuvant chemotherapy, we found that higher levels of genomic loss of heterozygosity were associated with a more significant tumor response to chemotherapy. Additionally, neoadjuvant therapy increased the population of tumor-infiltrating lymphocytes, primarily CD8+ T cells. These findings shed light on the dynamic interaction between tumors and the immune system, suggesting the potential use of immune checkpoint inhibitors or their combination with poly-ADP polymerase inhibitors as a treatment strategy for high-stage and grade epithelial ovarian cancer patients undergoing neoadjuvant therapy.
NPJ PRECISION ONCOLOGY
(2022)
Article
Genetics & Heredity
Maria Paula Melendez-Florez, Duvan Sebastian Valbuena, Sebastian Cepeda, Nelson Rangel, Maribel Forero-Castro, Maria Martinez-Aguero, Milena Rondon-Lagos
Summary: Pesticides, widely used in agriculture, have harmful effects on the health of individuals. Occupational exposure to pesticides in farmers is associated with increased chromosomal instability and clonal heterogeneity, consequently increasing the risk of diseases. This study highlights the importance of monitoring and addressing the risks associated with pesticide exposure.
FRONTIERS IN GENETICS
(2022)
Article
Physics, Fluids & Plasmas
Alberto Megias, Andres Santos
Summary: This study examines the conditions for stability under linear perturbations around the homogeneous cooling state for dilute granular gases of inelastic and rough hard disks or spheres. Transport coefficients derived from the Navier-Stokes-Fourier hydrodynamic equations are utilized, leading to novel results for hard disks and known results for hard spheres. The comparison with molecular dynamics simulations shows good agreement for moderate inelasticity but discrepancies for high inelasticity, suggesting limitations in the theoretical predictions.
Article
Cell Biology
Ana Milunovic-Jevtic, Predrag Jevtic, Daniel L. Levy, J. C. Gatlin
MOLECULAR BIOLOGY OF THE CELL
(2018)
Article
Materials Science, Biomaterials
Paige J. LeValley, Ben Noren, Prathamesh M. Kharkar, April M. Kloxin, Jesse C. Gatlin, John S. Oakey
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Paige J. LeValley, Ben Noren, Prathamesh M. Kharkar, April M. Kloxin, Jesse C. Gatlin, John S. Oakey
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Biochemistry & Molecular Biology
Jitender S. Bisht, Miroslav Tomschik, Jesse C. Gatlin
Article
Cell Biology
Pan Chen, Miroslav Tomschik, Katherine M. Nelson, John Oakey, Jesse C. Gatlin, Daniel L. Levy
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Zachary M. Geisterfer, Daniel Y. Zhu, Timothy J. Mitchison, John Oakey, Jesse C. Gatlin
Article
Computer Science, Interdisciplinary Applications
Samira Masoudi, Afsaneh Razi, Cameron H. G. Wright, Jesse C. Gatlin, Ulas Bagci
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Cell Biology
Taylor Sulerud, Abdullah Bashar Sami, Guihe Li, April Kloxin, John Oakey, Jesse Gatlin
MOLECULAR BIOLOGY OF THE CELL
(2020)
Review
Cell Biology
Zachary M. Geisterfer, Gabriel Guilloux, Jesse C. Gatlin, Romain Gibeaux
Summary: Egg extracts from the African clawed-frog have been a valuable experimental system in studying self-organization of the cytoskeleton. The simplified cell cycle, large experimental volumes, biochemical tractability, and cell-free nature of these extracts have uniquely benefited research in this area.
Article
Biology
V Leech, J. W. Hazel, J. C. Gatlin, A. E. Lindsay, A. Manhart
Summary: The correlation between cell size and nuclear size in different species and cell types has been observed, and a modeling framework based on the limiting component hypothesis has been formulated to study nuclear size determination mechanisms. Experimental data suggests that nuclear volume scales with cell volume.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Article
Cell Biology
Abdullah Bashar Sami, Jesse C. Gatlin
Summary: Changes in the cell's microtubule network can affect organelle organization, and the spatial arrangement of organelles can also influence the microtubule network. This study investigated the relationship between membranes and microtubules during microtubule aster centration, finding that dynein-dependent transport of membranes plays a crucial role in modulating aster architecture and position.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Multidisciplinary Sciences
Thao Nguyen, Eli J. Costa, Tim Deibert, Jose Reyes, Felix C. Keber, Miroslav Tomschik, Michael Stadlmeier, Meera Gupta, Chirag K. Kumar, Edward R. Cruz, Amanda Amodeo, Jesse C. Gatlin, Martin Wuhr
Summary: The study addresses how embryos control the timing of specific gene activation in early frog development. It is found that transcription factors for early gene activation are maternally loaded and remain at constant levels, and the order of activation is based on their sequential entry into the nucleus largely determined by their respective affinity to importins.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Zachary M. Geisterfer, John Oakey, Jesse C. Gatlin
Article
Biochemical Research Methods
Jitender Bisht, Paige LeValley, Benjamin Noren, Ralph McBride, Prathamesh Kharkar, April Kloxin, Jesse Gatlin, John Oakey
Article
Cell Biology
Paul Mooney, Taylor Sulerud, James F. Pelletier, Matthew R. Dilsaver, Miroslav Tomschik, Christoph Geisler, Jesse C. Gatlin
Review
Biochemical Research Methods
Pei-Ru Chen, Peng-Fei Xia
Summary: Carbon dioxide plays a crucial role in mitigating global climate change and supporting life on Earth. Synthetic biology and metabolic engineering offer a promising approach to enhance CO2 fixation by combining the advantages of autotrophic and heterotrophic organisms. This article reviews the current progress in constructing synthetic CO2 fixation pathways, discusses the underlying design principles and challenges, and provides insights into the future of carbon recycling through engineered synthetic carbon fixation pathways.
CURRENT OPINION IN BIOTECHNOLOGY
(2024)