Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research

(2020) Senthil T. Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia

(2020) Rashmi Das et al.   Journal of Neuroinflammation

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases

(2020) Michael A. Metrick et al.   Acta Neuropathologica Communications

Quantifying protein‐protein interactions by molecular counting with mass photometry

(2020) Fabian Soltermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain

(2020) Shaomin Li et al.   JOURNAL OF NEUROCHEMISTRY

Neuroimaging results altered by varying analysis pipelines

(2020) Martin Lindquist   NATURE

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Kinetic diversity of amyloid oligomers

(2020) Alexander J. Dear et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the heterogeneity of macromolecular machines by mass photometry

(2020) Adar Sonn-Segev et al.   Nature Communications

Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk

(2020) Rakez Kayed et al.   Journal of Parkinsons Disease

α-Synuclein Oligomer Detection with Aptamer Switch on Reduced Graphene Oxide Electrode

(2020) Seung Joo Jang et al.   Nanomaterials

Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers

(2020) Fantian Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Translational Scoring of Candidate Treatments for Alzheimer’s Disease: A Systematic Approach

(2020) Jeffrey L. Cummings   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Ultrasensitive Detection of Attomolar Protein Concentrations by Dropcast Single Molecule Assays

(2020) Connie Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

(2020) Jakob M Bader et al.   Molecular Systems Biology

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

(2020) Francesco A. Aprile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

(2020) Francesco Simone Ruggeri et al.   Nature Communications

Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes

(2020) Byeongseon Yang et al.   Frontiers in Molecular Biosciences

Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers

(2020) Tobias Lieblein et al.   eLife

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

(2019) Suman De et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

(2019) Ryan Limbocker et al.   Nature Communications

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme

(2019) Rachel Cliffe et al.   Cell Reports

Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis

(2019) Pietro Sormanni et al.   Cold Spring Harbor Perspectives in Biology

Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation

(2019) Femke van Diggelen et al.   PLoS One

Atomic force microscopy for single molecule characterisation of protein aggregation

(2019) Francesco Simone Ruggeri et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Seeding Variability of Different Alpha Synuclein Strains in Synucleinopathies

(2019) Niccolò Candelise et al.   ANNALS OF NEUROLOGY

α‐Synuclein real‐time quaking‐induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism

(2019) Anouke van Rumund et al.   ANNALS OF NEUROLOGY

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain

(2019) Gunnar Brinkmalm et al.   BRAIN

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease

(2019) Young Chul Youn et al.   Alzheimers Research & Therapy

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

α ‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK 2‐linked Parkinson's disease

(2019) Alicia Garrido et al.   Annals of Clinical and Translational Neurology

Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF

(2019) Ting Yang et al.   ANNALS OF NEUROLOGY

Human Positron Emission Tomography Neuroimaging

(2019) Jacob M. Hooker et al.   Annual Review of Biomedical Engineering

Engineered antibodies: new possibilities for brain PET?

(2019) Dag Sehlin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

(2019) Suman De et al.   Nature Communications

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

(2019) Suman De et al.   Acta Neuropathologica Communications

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

(2019) Parvez Alam et al.   JOURNAL OF NEUROCHEMISTRY

A dream of single-cell proteomics

(2019) Vivien Marx   NATURE METHODS

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

(2019) Chiara Maria Giulia De Luca et al.   Translational Neurodegeneration

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

(2019) Eri Saijo et al.   ACTA NEUROPATHOLOGICA

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

(2019) Martin Kiechle et al.   Cell Reports

α‐Synuclein RT‐QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

(2019) Matilde Bongianni et al.   Annals of Clinical and Translational Neurology

Mass spectrometry analysis of the structural proteome

(2019) Natalie de Souza et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

(2018) Franziska Kundel et al.   ACS Chemical Biology

Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions

(2018) Benedetta Mannini et al.   ACS Chemical Neuroscience

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

(2018) Magnus Kjaergaard et al.   ACS Chemical Neuroscience

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain

(2018) Wei Hong et al.   ACTA NEUROPATHOLOGICA

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates

(2018) Franziska Kundel et al.   FEBS Journal

Advancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases

(2018) Andreas Kulawik et al.   FEBS LETTERS

Aptamers Selected for Recognizing Amyloid β-Protein—A Case for Cautious Optimism

(2018) Farid Rahimi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer’s disease dementia to young controls

(2018) Tobey J Betthauser et al.   JOURNAL OF NUCLEAR MEDICINE

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

(2018) Dean F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

Hetero-oligomeric Amyloid Assembly and Mechanism: Prion Fragment PrP(106-126) Catalyzes the Islet Amyloid Polypeptide β-Hairpin

(2018) Alexandre Iourievich Ilitchev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA

(2018) Katelyn Becker et al.   MOLECULAR NEUROBIOLOGY

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

ELISA method to detect α-synuclein oligomers in cell and animal models

(2018) Louise Berkhoudt Lassen et al.   PLoS One

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease

(2018) Soyoon Sarah Hwang et al.   ANALYTICAL BIOCHEMISTRY

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing

(2018) William E. Arter et al.   ANALYTICAL CHEMISTRY

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

(2018) Daniel R. Whiten et al.   CHEMBIOCHEM

The Amyloid-β Oligomer Count in Cerebrospinal Fluid is a Biomarker for Alzheimer's Disease

(2018) Lei Wang-Dietrich et al.   JOURNAL OF ALZHEIMERS DISEASE

The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-β Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

(2018) Stina Tucker et al.   JOURNAL OF ALZHEIMERS DISEASE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

(2018) Francesco Simone Ruggeri et al.   Nature Communications

Recent advances in graphene-based biosensor technology with applications in life sciences

(2018) Janire Peña-Bahamonde et al.   JOURNAL OF NANOBIOTECHNOLOGY

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

(2018) Allison Kraus et al.   ACTA NEUROPATHOLOGICA

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

(2018) Ji-Eun Lee et al.   NANO LETTERS

Preparation of stable tau oligomers for cellular and biochemical studies

(2018) Thomas K. Karikari et al.   ANALYTICAL BIOCHEMISTRY

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

(2017) Neha Chauhan et al.   JOURNAL OF MATERIALS RESEARCH

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

NFGAIL Amyloid Oligomers: The Onset of Beta-Sheet Formation and the Mechanism for Fibril Formation

(2017) Waldemar Hoffmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Super-resolution microscopy with DNA-PAINT

(2017) Joerg Schnitzbauer et al.   Nature Protocols

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

(2017) Anna Munke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease

(2017) Min Jeong Wang et al.   Alzheimers Research & Therapy

AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson’s disease diagnosis

(2017) Hongli Zhao et al.   Protein & Cell

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

(2017) Urmi Sengupta et al.   Annals of Clinical and Translational Neurology

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

(2017) Francesco A. Aprile et al.   Science Advances

AlphaLISA immunoassays: the no-wash alternative to ELISAs for research and drug discovery

(2017) Lucille Beaudet et al.   NATURE METHODS

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

(2016) Mathew H. Horrocks et al.   ACS Chemical Neuroscience

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa

(2016) Jens Kuhle et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Single-molecule fluorescence microscopy of native macromolecular complexes

(2016) Vasudha Aggarwal et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

(2016) Francesco Simone Ruggeri et al.   CURRENT PHARMACEUTICAL DESIGN

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Biofunctionalized Silica Nanoparticles: Standards in Amyloid-β Oligomer-Based Diagnosis of Alzheimer’s Disease

(2016) Maren Hülsemann et al.   JOURNAL OF ALZHEIMERS DISEASE

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

Standardized Expression of 18F-NAV4694 and 11C-PiB  -Amyloid PET Results with the Centiloid Scale

(2016) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Droplet-based magnetic bead immunoassay using microchannel-connected multiwell plates (μCHAMPs) for the detection of amyloid beta oligomers

(2016) Min Cheol Park et al.   LAB ON A CHIP

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

(2016) Nour K. Majbour et al.   Molecular Neurodegeneration

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping

(2016) Marie N. Bongiovanni et al.   Nature Communications

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

(2016) Dag Sehlin et al.   Nature Communications

Application of an Amyloid Beta Oligomer Standard in the sFIDA Assay

(2016) Katja Kühbach et al.   Frontiers in Neuroscience

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Structural and functional properties of prefibrillar α-synuclein oligomers

(2016) Laura Pieri et al.   Scientific Reports

Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions

(2015) Irem Nasir et al.   ACS Chemical Neuroscience

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

(2015) Paolo Arosio et al.   ACS Nano

Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers

(2015) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

(2015) Pietro Sormanni et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical Fluorescent Probe for Detection of Aβ Oligomers

(2015) Chai Lean Teoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

(2015) Emma V. Yates et al.   Nature Chemistry

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth

(2015) Pei-Teh Chang et al.   NEUROPHARMACOLOGY

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

(2015) Pietro Sormanni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

(2015) Laura Tosatto et al.   Scientific Reports

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

(2015) Ting Yang et al.   Alzheimers Research & Therapy

A Sensitive A  Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

(2014) M. J. Savage et al.   JOURNAL OF NEUROSCIENCE

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity

(2013) Anat Burkovitz et al.   FEBS Journal

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease

(2013) Mikko Hölttä et al.   PLoS One

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid

(2013) Adrianna Z. Herskovits et al.   PLoS One

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue

(2012) Kim A. Bruggink et al.   ANALYTICAL BIOCHEMISTRY

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Unraveling the Early Events of Amyloid-β Protein (Aβ) Aggregation: Techniques for the Determination of Aβ Aggregate Size

(2012) N. Elizabeth Pryor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solubility evaluation of murine hybridoma antibodies

(2012) Stacey Spencer et al.   mAbs

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

DNA aptamers detecting generic amyloid epitopes

(2012) Olga V. Mitkevich et al.   Prion

Molecular basis of  -amyloid oligomer recognition with a conformational antibody fragment

(2012) I. Morgado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxic fibrillar oligomers of amyloid-  have cross-  structure

(2012) J. C. Stroud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates

(2011) Valerie L Anderson et al.   BMC BIOTECHNOLOGY

FRET detection of amyloid β-peptide oligomerization using a fluorescent protein probe presenting a pseudo-amyloid structure

(2011) Tsuyoshi Takahashi et al.   CHEMICAL COMMUNICATIONS

High Affinity, Developability and Functional Size: The Holy Grail of Combinatorial Antibody Library Generation

(2011) Dirk Ponsel et al.   MOLECULES

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

(2011) Ryuichiro Atarashi et al.   NATURE MEDICINE

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Aggregation Steps in α-Synuclein as Measured by FCS and FRET: Evidence for a Contagious Conformational Change

(2010) Sangeeta Nath et al.   BIOPHYSICAL JOURNAL

Detection of β-amyloid peptide (1–16) and amyloid precursor protein (APP770) using spectroscopic ellipsometry and QCM techniques: A step forward towards Alzheimers disease diagnostics

(2010) M.K. Mustafa et al.   BIOSENSORS & BIOELECTRONICS

HomoFRET Fluorescence Anisotropy Imaging as a Tool to Study Molecular Self-Assembly in Live Cells

(2010) Fiona T. S. Chan et al.   CHEMPHYSCHEM

High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients

(2010) Hiroaki Fukumoto et al.   FASEB JOURNAL

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

(2010) R. Blake Pepinsky et al.   PROTEIN SCIENCE

Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays

(2010) Jason M. Wilham et al.   PLoS Pathogens

Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of α-Synuclein Aggregation

(2009) Tjakko J. van Ham et al.   JOURNAL OF MOLECULAR BIOLOGY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Interplay of  -synuclein binding and conformational switching probed by single-molecule fluorescence

(2009) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

Detection and quantification of tau aggregation using a membrane filter assay

(2007) Edward Chang et al.   ANALYTICAL BIOCHEMISTRY