Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia

Microglia as modulators of exosomal alpha-synuclein transmission

(2019) Yun Xia et al.   Cell Death & Disease

Investigation of Neuregulin-1 and Glial Cell-Derived Neurotrophic Factor in Rodent Astrocytes and Microglia

(2019) Jessica Kronenberg et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization

(2019) Jitendra S. Rane et al.   BIOCHEMICAL JOURNAL

Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R

(2019) Xue-Lian Meng et al.   NEUROSCIENCE

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

(2019) Rashmi Das et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intersection of pathological tau and microglia at the synapse

(2019) Thomas Vogels et al.   Acta Neuropathologica Communications

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

(2019) Franco-Bocanegra et al.   Cells

Protein-Capped Metal Nanoparticles Inhibit Tau Aggregation in Alzheimer’s Disease

(2019) Shweta Kishor Sonawane et al.   ACS Omega

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer’s Disease

(2019) Nalini Vijay Gorantla et al.   ACS Omega

Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases

(2018) Chao Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis

(2018) Shweta Kishor Sonawane et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neurodegenerative disease: A proteostatic boost

(2018) Darran Yates   NATURE REVIEWS NEUROSCIENCE

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Tau Protein Squired by Molecular Chaperones During Alzheimer’s Disease

(2018) Nalini Vijay Gorantla et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

(2018) Sarah C. Hopp et al.   Journal of Neuroinflammation

Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats

(2018) Bianca Seminotti et al.   MOLECULAR NEUROBIOLOGY

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

(2018) Jack Brelstaff et al.   Cell Reports

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Dissecting functional phenotypes of microglia and macrophages in the rat brain after transient cerebral ischemia

(2018) Wenson D. Rajan et al.   GLIA

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Preparation of stable tau oligomers for cellular and biochemical studies

(2018) Thomas K. Karikari et al.   ANALYTICAL BIOCHEMISTRY

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

Microglia in central nervous system repair after injury

(2016) Xuemei Jin et al.   JOURNAL OF BIOCHEMISTRY

Formation, release, and internalization of stable tau oligomers in cells

(2016) Susanne Wegmann et al.   JOURNAL OF NEUROCHEMISTRY

The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

(2016) Jonathan J. Sabbagh et al.   Frontiers in Neuroscience

Actin dynamics shape microglia effector functions

(2015) Ria Uhlemann et al.   Brain Structure & Function

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Therapeutic Mechanisms of Tau Antibodies

(2015) Kristen E. Funk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia mechanics: immune activation alters traction forces and durotaxis

(2015) Lars Bollmann et al.   Frontiers in Cellular Neuroscience

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells

(2014) Katharina Tepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia display modest phagocytic capacity for extracellular tau oligomers

(2014) Petra Majerova et al.   Journal of Neuroinflammation

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Can we talk about microglia without neurons? A discussion of microglial cell autonomous properties in culture

(2014) Ismael Neiva et al.   Frontiers in Cellular Neuroscience

Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin - a postembedding immunogold study in the healthy rat brain

(2013) Carl J. L. Sogn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Abnormal Activation of Microglia Accompanied with Disrupted CX3CR1/CX3CL1 Pathway in the Brains of the Hamsters Infected with Scrapie Agent 263K

(2013) Wu-Ling Xie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

(2013) Starlee Lively et al.   Journal of Neuroinflammation

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

(2013) Lu Wang et al.   PLoS One

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

FTDP-17 Tau Mutations Induce Distinct Effects on Aggregation and Microtubule Interactions

(2012) Benjamin Combs et al.   BIOCHEMISTRY

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

(2012) Hong-Cui Liu et al.   CELLULAR IMMUNOLOGY

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

(2012) Katharina Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of podosome formation, microglial migration and invasion by Ca2+-signaling molecules expressed in podosomes

(2012) Tamjeed A Siddiqui et al.   Journal of Neuroinflammation

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Tau cleavage and tau aggregation in neurodegenerative disease: Figure 1

(2010) Diane P. Hanger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA