Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

(2013) Erik Hellstrand et al.   PLoS One

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Alpha-synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease

(2011) Arianna Bellucci et al.   BRAIN RESEARCH

The mode of α-synuclein binding to membranes depends on lipid composition and lipid to protein ratio

(2011) Volodymyr V. Shvadchak et al.   FEBS LETTERS

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation

(2010) Celia Cabaleiro-Lago et al.   ACS Chemical Neuroscience

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

(2010) Lise Giehm et al.   ANALYTICAL BIOCHEMISTRY

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Assays for α-synuclein aggregation

(2010) Lise Giehm et al.   METHODS

The behavior of α-synuclein in neurons

(2010) Doris L. Fortin et al.   MOVEMENT DISORDERS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

(2010) Alexander K. Buell et al.   PHYSICAL REVIEW LETTERS

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA