Beyond natural antibodies: the power of in vitro display technologies

Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies

(2010) Herbert A. Runnels et al.   ADVANCES IN THERAPY

Bispecific Antibodies for Cancer Immunotherapy

(2010) Dafne Müller et al.   BIODRUGS

Antibody validation

(2010) Jennifer Bordeaux et al.   BIOTECHNIQUES

Internalizing Cancer Antibodies from Phage Libraries Selected on Tumor Cells and Yeast-Displayed Tumor Antigens

(2010) Yu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent

(2010) Séverine Fagète et al.   mAbs

Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

(2010) Claire L. Dobson et al.   mAbs

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

(2010) Sai T Reddy et al.   NATURE BIOTECHNOLOGY

Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS

(2010) Suzanne R. Kalb et al.   PLoS One

Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display

(2010) K. Pershad et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Generating recombinant antibodies to the complete human proteome

(2010) Stefan Dübel et al.   TRENDS IN BIOTECHNOLOGY

Phage-displayed antibody fragments recognizing dengue 3 and dengue 4 viruses as tools for viral serotyping in sera from infected individuals

(2009) Sheila Cabezas et al.   ARCHIVES OF VIROLOGY

Targeted Tumor Therapies at a Glance

(2009) H. Fuchs et al.   CURRENT DRUG TARGETS

Current Constructs and Targets in Clinical Development for Antibody- Based Cancer Therapy

(2009) P. Deckert   CURRENT DRUG TARGETS

A rapid and efficient single-cell manipulation method for screening antigen-specific antibody–secreting cells from human peripheral blood

(2009) Aishun Jin et al.   NATURE MEDICINE

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multimerization domains for antibody phage display and antibody production

(2009) H. Thie et al.   New Biotechnology

Towards proteome scale antibody selections using phage display

(2009) Michael Mersmann et al.   New Biotechnology

Generation, Characterization and Epitope Mapping of Two Neutralizing and Protective Human Recombinant Antibodies against Influenza A H5N1 Viruses

(2009) Lina Sun et al.   PLoS One

An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells

(2009) S. S. Rizk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-state selection of conformation-specific antibodies

(2009) J. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of full-length KcsA in its closed conformation

(2009) S. Uysal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

(2009) J. Grunewald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

(2009) J. Bostrom et al.   SCIENCE

Monoclonal antibodies in man that neutralized H3N2 influenza viruses were classified into three groups with distinct strain specificity: 1968–1973, 1977–1993 and 1997–2003

(2009) Jun Okada et al.   VIROLOGY

Identification of a Strongly Activating Human Anti-CD40 Antibody That Suppresses HIV Type 1 Infection

(2008) Peter Ellmark et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV)

(2008) Martina Kirsch et al.   BMC BIOTECHNOLOGY

Effector mechanisms of therapeutic antibodies against ErbB receptors

(2008) Matthias Peipp et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular engineering and design of therapeutic antibodies

(2008) Leonard G Presta   CURRENT OPINION IN IMMUNOLOGY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Microscale characterization of the binding specificity and affinity of a monoclonal antisulfotyrosyl IgG antibody

(2008) Klaus S. Lassen et al.   ELECTROPHORESIS

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculaturein vivo

(2008) Alessandra Villa et al.   INTERNATIONAL JOURNAL OF CANCER

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Anti-gold Antibodies

(2008) Hideki Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies

(2008) N. Strebe et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!

(2008) Natasha L. Grimsey et al.   JOURNAL OF NEUROSCIENCE METHODS

Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice

(2008) Gitte Jositsch et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific

(2008) Brian C. Jensen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens

(2008) C. Lloyd et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library

(2008) Angeline PC Lim et al.   Virology Journal