The Adhesome Network: Key Components Shaping the Tumour Stroma

FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

(2020) Hsin-Jung Wu et al.   ONCOGENE

Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking

(2020) Zachary S. Wilson et al.   Scientific Reports

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

(2020) Marta Canel et al.   eLife

Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease

(2020) Kaimin Zhang et al.   Frontiers in Cell and Developmental Biology

Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

(2020) Ping-Pui Wong et al.   CELL

Tumor microenvironment complexity and therapeutic implications at a glance

(2020) Roghayyeh Baghban et al.   Cell Communication and Signaling

RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells

(2020) Yoko Fukushima et al.   EMBO JOURNAL

Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling

(2020) Thomas Jun Feng Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kindlin‐3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance

(2020) Paola M. Marcovecchio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cancer associated fibroblast FAK regulates malignant cell metabolism

(2020) Fevzi Demircioglu et al.   Nature Communications

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(2020) Sylvie Brassart-Pasco et al.   Frontiers in Oncology

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

(2020) Tanguy Lechertier et al.   Nature Communications

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

(2020) Sonia Zaghdoudi et al.   EMBO Molecular Medicine

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function

(2019) Fadi E. Pulous et al.   CIRCULATION RESEARCH

EZH2 inhibitor GSK126 suppresses anti-tumor immunity by driving production of myeloid-derived suppressor cells

(2019) Shuo Huang et al.   CANCER RESEARCH

DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs

(2019) Samantha VH Bayer et al.   eLife

Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects

(2019) Barbara Bassani et al.   Cancers

Cancer-associated fibroblasts—heroes or villains?

(2019) Krystyna A. Gieniec et al.   BRITISH JOURNAL OF CANCER

Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861

(2019) Ana-Rita Pedrosa et al.   CANCER RESEARCH

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

(2019) Jin Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

T Cell Dysfunction in Cancer Immunity and Immunotherapy

(2019) Anliang Xia et al.   Frontiers in Immunology

Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway

(2019) Shengzhou Shan et al.   FASEB JOURNAL

Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma

(2019) Zeli Yin et al.   Journal of Hematology & Oncology

Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers

(2019) Karoline Kielbassa et al.   Frontiers in Immunology

Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis

(2019) Valentin Jaumouillé et al.   NATURE CELL BIOLOGY

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

(2019) Hongryeol Park et al.   Nature Communications

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

(2019) Fatema Tuz Zahra et al.   Scientific Reports

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

(2019) Kai Wang et al.   CANCER LETTERS

Parvins Are Required for Endothelial Cell–Cell Junctions and Cell Polarity During Embryonic Blood Vessel FormationHighlights

(2018) Bettina Pitter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking

(2018) Terhi Savinko et al.   JOURNAL OF IMMUNOLOGY

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

(2018) Ekrem Emrah Er et al.   NATURE CELL BIOLOGY

Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity

(2018) Jiaxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis

(2018) Alba Manresa-Arraut et al.   Frontiers in Immunology

Diverse Functions of Macrophages in Different Tumor Microenvironments

(2018) Ming Yang et al.   CANCER RESEARCH

The Emerging Role of CD8+ Tissue Resident Memory T (TRM) Cells in Antitumor Immunity: A Unique Functional Contribution of the CD103 Integrin

(2018) Stéphanie Corgnac et al.   Frontiers in Immunology

Super-Resolution Correlative Light and Electron Microscopy (SR-CLEM) Reveals Novel Ultrastructural Insights Into Dendritic Cell Podosomes

(2018) Ben Joosten et al.   Frontiers in Immunology

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

(2018) Thomas Bromberger et al.   BLOOD

Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment

(2018) J. M. Houthuijzen et al.   CANCER AND METASTASIS REVIEWS

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VASP Regulates NK Cell Lytic Granule Convergence

(2018) Katelynn M. Wilton et al.   JOURNAL OF IMMUNOLOGY

Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality

(2018) Thomas Jun Feng Lim et al.   JOURNAL OF IMMUNOLOGY

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

FAK inhibitors induce cell multinucleation and dramatically increase pro-tumoral cytokine expression in RAW 264.7 macrophages

(2017) Xia He et al.   FEBS LETTERS

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Paxillin: a crossroad in pathological cell migration

(2017) Ana María López-Colomé et al.   Journal of Hematology & Oncology

Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release

(2017) Liisa M. Uotila et al.   JOURNAL OF IMMUNOLOGY

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

(2017) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state

(2017) Ryan A. Llewellyn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice

(2017) Annika N Alexopoulou et al.   JOURNAL OF PATHOLOGY

Kindlin-2 interacts with endothelial adherens junctions to support vascular barrier integrity

(2017) Elzbieta Pluskota et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration

(2017) Miriam L. Estin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

(2017) Xiaofan Han et al.   Nature Communications

Effects of increased Kindlin-2 expression in bladder cancer stromal fibroblasts

(2017) Jitao Wu et al.   Oncotarget

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer

(2017) Stefan N. Symeonides et al.   Journal for ImmunoTherapy of Cancer

Cancer-associated fibroblasts support vascular growth through mechanical force

(2017) Mary Kathryn Sewell-Loftin et al.   Scientific Reports

The Emerging Role of B Cells in Tumor Immunity

(2016) Peiling Tsou et al.   CANCER RESEARCH

Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses

(2016) Anna A. Birukova et al.   CELLULAR SIGNALLING

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

(2016) Adam Byron et al.   CURRENT OPINION IN CELL BIOLOGY

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis

(2016) Nijiro Nohata et al.   DEVELOPMENTAL BIOLOGY

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Micro–adhesion rings surrounding TCR microclusters are essential for T cell activation

(2016) Akiko Hashimoto-Tane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion

(2016) Samuel M. S. Cheung et al.   JOURNAL OF IMMUNOLOGY

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Stromal Palladin Expression Is an Independent Prognostic Factor in Pancreatic Ductal Adenocarcinoma

(2016) Daisuke Sato et al.   PLoS One

The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts

(2016) Mikheil Azatov et al.   Scientific Reports

The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

(2016) Ting-Ting Shi et al.   Biomed Research International

c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury

(2015) Panfeng Fu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tensin1 positively regulates RhoA activity through its interaction with DLC1

(2015) Yi-Ping Shih et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Palladin Mediates Stiffness-Induced Fibroblast Activation in the Tumor Microenvironment

(2015) Joshua S. McLane et al.   BIOPHYSICAL JOURNAL

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

(2015) S. Klapproth et al.   BLOOD

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Endothelial Alpha-Parvin Controls Integrity of Developing Vasculature and Is Required for Maintenance of Cell-Cell Junctions

(2015) A. Fraccaroli et al.   CIRCULATION RESEARCH

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

(2015) L. Martinez-Lostao et al.   CLINICAL CANCER RESEARCH

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

(2015) D. M. Barry et al.   DEVELOPMENT

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner

(2015) Maria Steblyanko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

(2015) Merry Gunawan et al.   NATURE IMMUNOLOGY

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells

(2015) S. Ghosh et al.   Journal of the American Heart Association

Role Played by Paxillin and Paxillin Tyrosine Phosphorylation in Hepatocyte Growth Factor/Sphingosine-1-Phosphate-Mediated Reactive Oxygen Species Generation, Lamellipodia Formation, and Endothelial Barrier Function

(2015) Panfeng Fu et al.   Pulmonary Circulation

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

(2014) Chan Kim et al.   CANCER CELL

Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors

(2014) Kangsheng Tu et al.   HEPATOLOGY

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

(2014) Nicole M. Chapman et al.   IMMUNOLOGIC RESEARCH

Focal Adhesion Kinase Knockdown in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis via Downregulating MCP-1/CCL2 Expression

(2014) Anjie Min et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression

(2014) A. E. German et al.   JOURNAL OF CELL SCIENCE

Podosomes of dendritic cells facilitate antigen sampling

(2014) M. V. Baranov et al.   JOURNAL OF CELL SCIENCE

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly

(2014) E. Wilson et al.   JOURNAL OF CELL SCIENCE

A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells

(2014) E. M. Mace et al.   JOURNAL OF IMMUNOLOGY

 PIX RhoGEF Supports Positive Selection by Restraining Migration and Promoting Arrest of Thymocytes

(2014) M. Korthals et al.   JOURNAL OF IMMUNOLOGY

Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells

(2014) Nicole M. Chapman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Matrix Stiffening and β 1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer

(2014) Marta Puig et al.   MOLECULAR CANCER RESEARCH

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful

(2014) H.-J. Kim et al.   Cancer Immunology Research

Deletion of FHL2 Gene Impaired Ischemia-Induced Blood Flow Recovery by Modulating Circulating Proangiogenic Cells

(2013) Po-Hsun Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation

(2013) Andrew J. Wiemer et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Four-and-a-Half LIM Domain Protein-2 Increases Survival, Migratory Capacity, and Paracrine Function of Human Early Outgrowth Cells Through Activation of the Sphingosine Kinase-1 Pathway

(2013) Talin Ebrahimian et al.   CIRCULATION RESEARCH

Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization

(2013) D. Malan et al.   DEVELOPMENT

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor

(2013) N. M. Chapman et al.   JOURNAL OF IMMUNOLOGY

Vinculin Arrests Motile B Cells by Stabilizing Integrin Clustering at the Immune Synapse

(2013) J. Saez de Guinoa et al.   JOURNAL OF IMMUNOLOGY

Control of Dendritic Cell Migration, T Cell-Dependent Immunity, and Autoimmunity by Protein Tyrosine Phosphatase PTPN12 Expressed in Dendritic Cells

(2013) Inmoo Rhee et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis

(2013) Y. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts

(2013) S M Goicoechea et al.   ONCOGENE

Filamin-A Regulates Neutrophil Uropod Retraction through RhoA during Chemotaxis

(2013) Chunxiang Sun et al.   PLoS One

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

(2013) F. A. Moretti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAK-heterozygous mice display enhanced tumour angiogenesis

(2013) Vassiliki Kostourou et al.   Nature Communications

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

(2012) Julia Tchou et al.   BMC Medical Genomics

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β

(2012) Jing Lin et al.   IUBMB LIFE

Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1

(2012) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

(2012) Stephan Huveneers et al.   JOURNAL OF CELL BIOLOGY

Focal Adhesion Kinase Regulates the Localization and Retention of Pro-B Cells in Bone Marrow Microenvironments

(2012) S.-Y. Park et al.   JOURNAL OF IMMUNOLOGY

Targeting filamin A reduces K-RAS–induced lung adenocarcinomas and endothelial response to tumor growth in mice

(2012) Rajesh K Nallapalli et al.   Molecular Cancer

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Arousal of Cancer-Associated Stroma: Overexpression of Palladin Activates Fibroblasts to Promote Tumor Invasion

(2012) Teresa A. Brentnall et al.   PLoS One

RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development

(2012) Shuangmin Zhang et al.   PLoS One

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach

(2011) P. Vader et al.   ANGIOGENESIS

The role of RhoJ in endothelial cell biology and angiogenesis

(2011) Katarzyna Leszczynska et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish

(2011) E. Pluskota et al.   BLOOD

RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG

(2011) L. Yuan et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration

(2011) Sean A. Parsons et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vasodilator Phosphostimulated Protein (VASP) Protects Endothelial Barrier Function During Hypoxia

(2011) Marthe A. Schmit et al.   INFLAMMATION

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

 2 Integrin Induces TCR -Syk-Phospholipase C-  Phosphorylation and Paxillin-Dependent Granule Polarization in Human NK Cells

(2011) M. E. March et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway

(2011) A A Wani et al.   ONCOGENE

Distinct Roles of Cdc42 in Thymopoiesis and Effector and Memory T Cell Differentiation

(2011) Fukun Guo et al.   PLoS One

Elevated Expression of Stromal Palladin Predicts Poor Clinical Outcome in Renal Cell Carcinoma

(2011) Vivekanand Gupta et al.   PLoS One

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Focal Adhesion Assembly in Myofibroblasts Fosters a Microenvironment that Promotes Tumor Growth

(2010) Ningling Kang et al.   AMERICAN JOURNAL OF PATHOLOGY

RhoJ/TCL Regulates Endothelial Motility and Tube Formation and Modulates Actomyosin Contractility and Focal Adhesion Numbers

(2010) Sukhbir Kaur et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes

(2010) M. Faroudi et al.   BLOOD

Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen

(2010) E. Manevich-Mendelson et al.   BLOOD

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood-Brain Barrier in Glioma

(2010) J. Lee et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Zyxin Mediation of Stretch-Induced Gene Expression in Human Endothelial Cells

(2010) Agnieszka Wójtowicz et al.   CIRCULATION RESEARCH

Adhesion signalling complexes

(2010) Adam Byron et al.   CURRENT BIOLOGY

Endothelial cell talin1 is essential for embryonic angiogenesis

(2010) Susan J. Monkley et al.   DEVELOPMENTAL BIOLOGY

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Filamin B Plays a Key Role in Vascular Endothelial Growth Factor-induced Endothelial Cell Motility through Its Interaction with Rac-1 and Vav-2

(2010) Beatriz del Valle-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

(2010) Robert B. Henderson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vasodilator-Stimulated Phosphoprotein Regulates Inside-Out Signaling of  2 Integrins in Neutrophils

(2010) R. K. Deevi et al.   JOURNAL OF IMMUNOLOGY

Four-and-a-Half LIM Domain Protein 2 Is a Novel Regulator of Sphingosine 1-Phosphate Receptor 1 in CCL19-Induced Dendritic Cell Migration

(2010) K. Konig et al.   JOURNAL OF IMMUNOLOGY

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

(2010) L. A. Kamen et al.   JOURNAL OF IMMUNOLOGY

Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events

(2010) Michelle Y. Abshire et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness

(2010) Maciej Kotecki et al.   MICROVASCULAR RESEARCH

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent

(2010) Gabriela D'Amico et al.   PLoS One

Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors

(2010) Silvia M. Goicoechea et al.   PLoS One

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis

(2010) F. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

(2010) S. Beinke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1

(2009) Hiroki Hayashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation

(2009) F. Guo et al.   BLOOD

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Regulation of lymphatic-blood vessel separation by endothelial Rac1

(2009) G. D'Amico et al.   DEVELOPMENT

α-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

(2009) Eloi Montanez et al.   EMBO JOURNAL

Targeting focal adhesion kinase signaling in tumor growth and metastasis

(2009) Joerg Schwock et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction

(2009) N. Kogata et al.   GENES & DEVELOPMENT

Autophosphorylation-independent and -dependent Functions of Focal Adhesion Kinase during Development

(2009) Jean-Marc Corsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

(2009) Kathy W. K. Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals

(2009) A. Kasorn et al.   JOURNAL OF IMMUNOLOGY

PYK2 interacts with MyD88 and regulates MyD88-mediated NF- B activation in macrophages

(2009) C.-X. Xi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development

(2008) F. Guo et al.   BLOOD

Rac GTPases play critical roles in early T-cell development

(2008) C. Dumont et al.   BLOOD

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

 PIX Rho GTPase Guanine Nucleotide Exchange Factor Regulates Lymphocyte Functions and Antigen Receptor Signaling

(2008) K. Missy et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)

(2008) L. A. Edwards et al.   MOLECULAR CANCER THERAPEUTICS

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization

(2007) N. Schlegel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY