Targeting focal adhesion kinase signaling in tumor growth and metastasis

FERM control of FAK function: Implications for cancer therapy

(2014) Ssang-Taek Lim et al.   CELL CYCLE

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

(2011) Steven N. Hochwald et al.   CELL CYCLE

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

(2010) Cedo M Bagi et al.   CANCER BIOLOGY & THERAPY

Regulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells

(2009) Y Xu et al.   BRITISH JOURNAL OF CANCER

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH

EphA2 Reexpression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style

(2009) M. Parri et al.   CANCER RESEARCH

Targeting Focal Adhesion Kinase with Dominant-Negative FRNK or Hsp90 Inhibitor 17-DMAG Suppresses Tumor Growth and Metastasis of SiHa Cervical Xenografts

(2009) J. Schwock et al.   CANCER RESEARCH

Transforming Growth Factor   Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton

(2009) S. E. Wang et al.   CANCER RESEARCH

 v 3/ v 5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma

(2009) N. Skuli et al.   CANCER RESEARCH

Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

(2009) Y.-Q. Xiong et al.   CLINICAL CANCER RESEARCH

EMT 2.0: shaping epithelia through collective migration

(2009) Céline Revenu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility

(2009) Martine H. A. M. van Miltenburg et al.   FASEB JOURNAL

Impact of heat-shock protein 90 on cancer metastasis

(2009) Shinji Tsutsumi et al.   Future Oncology

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

(2009) Keefe T. Chan et al.   JOURNAL OF CELL BIOLOGY

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

(2009) J. K. Slack-Davis et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor

(2009) K. Sakurama et al.   MOLECULAR CANCER THERAPEUTICS

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal Adhesion Kinase-Related Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase Are Co-Overexpressed in Early-Stage and Invasive ErbB-2-Positive Breast Cancer and Cooperate for Breast Cancer Cell Tumorigenesis and Invasiveness

(2008) Emy Behmoaram et al.   AMERICAN JOURNAL OF PATHOLOGY

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

(2008) Paolo P. Provenzano et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery and development of heat shock protein 90 inhibitors

(2008) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3

(2008) Gabriela Magenta et al.   BMC CANCER

Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors

(2008) Cedo M. Bagi et al.   CANCER

Focal adhesion kinase as an immunotherapeutic target

(2008) Hiroya Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TAE226 Inhibits Human Neuroblastoma Cell Survival

(2008) Elizabeth A. Beierle et al.   CANCER INVESTIGATION

An Intracellular Signal Pathway That Regulates Cancer Cell Adhesion in Response to Extracellular Forces

(2008) M. D. Basson   CANCER RESEARCH

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Establishment of Cell Lines from Mouse Embryos with Early Embryonic Lethality

(2008) Kyle Howerton et al.   CELL COMMUNICATION AND ADHESION

Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis models

(2008) Tatsuhiko Kasaoka et al.   CLINICAL & EXPERIMENTAL METASTASIS

Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo

(2008) N. Watanabe et al.   CLINICAL CANCER RESEARCH

Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice

(2008) Sven A. Lang et al.   HEPATOLOGY

Caveolin-1 Up-regulation during Epithelial to Mesenchymal Transition Is Mediated by Focal Adhesion Kinase

(2008) Kelly M. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

(2008) Vita M. Golubovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

17-Allylamino-17-Demethoxygeldanamycin Down-Regulates Hyaluronic Acid-Induced Glioma Invasion by Blocking Matrix Metalloproteinase-9 Secretion

(2008) M.-S. Kim et al.   MOLECULAR CANCER RESEARCH

Troglitazone inhibits cell migration, adhesion, and spreading by modulating cytoskeletal rearrangement in human breast cancer cells

(2008) Pei-Shan Wang et al.   MOLECULAR CARCINOGENESIS

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells

(2008) Jang-Chang Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

(2008) Daniel Lietha et al.   PLoS One

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

(2008) A. Yano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice

(2008) X. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

(2007) Carla Cicchini et al.   EXPERIMENTAL CELL RESEARCH

TAE226-Induced apoptosis in breast cancer cells with overexpressed Src or EGFR

(2007) Vita M. Golubovskaya et al.   MOLECULAR CARCINOGENESIS

Focal adhesion kinase as a regulator of cell tension in the progression of cancer

(2007) Robert W. Tilghman et al.   SEMINARS IN CANCER BIOLOGY