Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner

(2015) Maria Steblyanko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1

(2015) Ana Dios-Esponera et al.   MOLECULAR BIOLOGY OF THE CELL

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

(2014) Nicole M. Chapman et al.   IMMUNOLOGIC RESEARCH

A signaling network stimulated by  2 integrin promotes the polarization of lytic granules in cytotoxic cells

(2014) M. Zhang et al.   Science Signaling

A Role for the Protein Tyrosine Phosphatase CD45 in Macrophage Adhesion through the Regulation of Paxillin Degradation

(2013) Joëlle St-Pierre et al.   PLoS One

Integrin trafficking at a glance

(2012) R. E. Bridgewater et al.   JOURNAL OF CELL SCIENCE

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Paxillin Associates with the Microtubule Cytoskeleton and the Immunological Synapse of CTL through Its Leucine-Aspartic Acid Domains and Contributes to Microtubule Organizing Center Reorientation

(2011) L. K. Robertson et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Tyrosine Kinase Pyk2 by Calcium Is through Production of Reactive Oxygen Species in Cytotoxic T Lymphocytes

(2010) Tara L. Lysechko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

(2010) L. A. Kamen et al.   JOURNAL OF IMMUNOLOGY

Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells

(2010) Lin Wang et al.   Journal of Inflammation-London

Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis

(2010) Peter C. Bonnette et al.   Journal of Proteomics

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells

(2010) Michaela Collins et al.   MOLECULAR IMMUNOLOGY

Calpain 2 Controls Turnover of LFA-1 Adhesions on Migrating T Lymphocytes

(2010) Lena Svensson et al.   PLoS One

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

(2009) Kathy W. K. Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline-Rich Tyrosine Kinase 2 Regulates Spreading and Migration of Eosinophils after β2-Integrin Adhesion

(2008) Xiangdong Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

(2008) Daniel P. Walker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS