FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice

(2018) Shaogang Sun et al.   Scientific Reports

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer

(2017) Stefan N. Symeonides et al.   Journal for ImmunoTherapy of Cancer

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

The Role of Mir-148a in Cancer

(2016) Yue Li et al.   Journal of Cancer

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

(2014) Masayuki Shimoda et al.   NATURE CELL BIOLOGY

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

(2013) M. Luo et al.   CANCER RESEARCH

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Mesenchymal-Specific Deletion of C/EBPβ Suppresses Pulmonary Fibrosis

(2012) Biao Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activitiesin Vivo

(2012) Huaping Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

(2008) Paolo P. Provenzano et al.   AMERICAN JOURNAL OF PATHOLOGY