Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

(2017) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function–Associated Antigen-1 and Kindlin-3

(2015) Vicky Louise Morrison et al.   JOURNAL OF IMMUNOLOGY

Functional Beta2-Integrins Restrict Skin Inflammation In Vivo

(2015) Terhi S. Savinko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation

(2015) Xu-Dong Wang et al.   NATURE IMMUNOLOGY

Structural mechanism of integrin inactivation by filamin

(2015) Jianmin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural mechanism of integrin inactivation by filamin

(2015) Jianmin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanical regulation of T-cell functions

(2014) Wei Chen et al.   IMMUNOLOGICAL REVIEWS

Involvement of IKAP in Peripheral Target Innervation and in Specific JNK and NGF Signaling in Developing PNS Neurons

(2014) Anastasia Abashidze et al.   PLoS One

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

(2014) Vicky Louise Morrison et al.   Nature Communications

The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

(2013) S. J. Cohen et al.   BLOOD

The  2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

(2013) V. L. Morrison et al.   BLOOD

The Spontaneously Adhesive Leukocyte Function-associated Antigen-1 (LFA-1) Integrin in Effector T Cells Mediates Rapid Actin- and Calmodulin-dependent Adhesion Strengthening to Ligand under Shear Flow

(2013) Hwee San Lek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filamins in Mechanosensing and Signaling

(2012) Ziba Razinia et al.   Annual Review of Biophysics

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1

(2011) M. Gronholm et al.   JOURNAL OF IMMUNOLOGY

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

(2011) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

(2010) Hervé Falet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness

(2009) Ramaswamy Krishnan et al.   PLoS One

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD