Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

(2016) Katarzyna Plak et al.   BMC CELL BIOLOGY

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

(2015) S. Klapproth et al.   BLOOD

Rap1 and its effector RIAM are required for lymphocyte trafficking

(2015) W. Su et al.   BLOOD

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range

(2014) Marlis Zeiler et al.   MOLECULAR & CELLULAR PROTEOMICS

 1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse

(2013) T. Petzold et al.   BLOOD

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2synthesis

(2011) Kyle R Legate et al.   EMBO JOURNAL

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL