PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

(2018) Chune Ren et al.   Molecular Oncology

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

(2017) Carsten Denkert et al.   LANCET

PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells

(2016) Zhenhai Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assessment of Total Lesion Glycolysis by 18 F FDG PET/CT Significantly Improves Prognostic Value of GEP and ISS in Myeloma

(2016) James E. McDonald et al.   CLINICAL CANCER RESEARCH

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer

(2015) Nizam Uddin et al.   CANCER SCIENCE

Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors

(2015) Xue-hui Zhang et al.   International Journal of Medical Sciences

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation

(2015) Guoping Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

(2015) Hong-guang Xia et al.   JOURNAL OF CELL BIOLOGY

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells

(2014) Zhenhai Yu et al.   CELLULAR SIGNALLING

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

(2014) David J. Roberts et al.   MOLECULAR CELL

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PIM Family of Serine/Threonine Kinases in Cancer

(2013) Maja Narlik-Grassow et al.   MEDICINAL RESEARCH REVIEWS

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

(2012) Carmen Blanco-Aparicio et al.   BIOCHEMICAL PHARMACOLOGY

A novel miR-155/miR-143 cascade controls glycolysis by regulatinghexokinase 2in breast cancer cells

(2012) Shuai Jiang et al.   EMBO JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL