Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin

The current status of checkpoint inhibitors in metastatic bladder cancer

(2016) Omar Fahmy et al.   CLINICAL & EXPERIMENTAL METASTASIS

Bladder cancer

(2016) Ashish M Kamat et al.   LANCET

Pyruvate kinase M2 at a glance

(2015) W. Yang et al.   JOURNAL OF CELL SCIENCE

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer

(2014) Woonyoung Choi et al.   Nature Reviews Urology

Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy

(2013) I. Andujar et al.   CURRENT MEDICINAL CHEMISTRY

Molecular mechanisms of cisplatin resistance in bladder cancer

(2012) Ross M Drayton et al.   Expert Review of Anticancer Therapy

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

(2012) Michael S. Goldberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Warburg effect in 2012

(2011) Jean-Pierre Bayley et al.   CURRENT OPINION IN ONCOLOGY

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA

(2010) M. Chen et al.   CANCER RESEARCH

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human pyruvate kinase M2: A multifunctional protein

(2010) Vibhor Gupta et al.   PROTEIN SCIENCE

Key concerns about the current state of bladder cancer

(2009) Yair Lotan et al.   CANCER