Metabolic Reprogramming During Multidrug Resistance in Leukemias

Towards Comprehension of the ABCB1/P-Glycoprotein Role in Chronic Myeloid Leukemia

(2018) Raquel Maia et al.   MOLECULES

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death

(2017) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes

(2017) Jibin Guan et al.   Nanoscale

Physical and biological characteristics of multi drug resistance (MDR): An integral approach considering pH and drug resistance in cancer

(2017) Ziad Omran et al.   SEMINARS IN CANCER BIOLOGY

Tuberostemonine reverses multidrug resistance in chronic myelogenous leukemia cells K562/ADR

(2017) Yu Jia Wang et al.   Journal of Cancer

GAPDH binds Akt to facilitate cargo transport in the early secretory pathway

(2016) Ellen J. Tisdale et al.   EXPERIMENTAL CELL RESEARCH

Low ABCB1 and high OCT1 levels play a favorable role in the molecular response to imatinib in CML patients in the community clinical practice

(2016) Flavia da Cunha Vasconcelos et al.   LEUKEMIA RESEARCH

Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

(2016) Aysegul Cort et al.   Oxidative Medicine and Cellular Longevity

Long-Term Alteration of Reactive Oxygen Species Led to Multidrug Resistance in MCF-7 Cells

(2016) Juan Cen et al.   Oxidative Medicine and Cellular Longevity

Energy metabolism in the acquisition and maintenance of stemness

(2016) Clifford D.L. Folmes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Hes1: a key role in stemness, metastasis and multidrug resistance

(2015) Zi-Hao Liu et al.   CANCER BIOLOGY & THERAPY

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Collateral sensitivity to cold stress and differential BCL-2 family expression in new daunomycin-resistant lymphoblastoid cell lines

(2015) David Cerezo et al.   EXPERIMENTAL CELL RESEARCH

Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke

(2015) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative proteomics analysis of differential proteins in respond to doxorubicin resistance in myelogenous leukemia cell lines

(2015) Shi Qinghong et al.   Proteome Science

Chemical genetics and its application to moonlighting in glycolytic enzymes

(2014) Da-Woon Jung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Granzyme B-induced mitochondrial ROS are required for apoptosis

(2014) G Jacquemin et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Chromosome translocation may lead to PRK1-dependent anticancer drug resistance in yeast via endocytic actin network deregulation

(2014) Dmitri V. Nikitin et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Glucose-6-phosphate dehydrogenase – beyond the realm of red cell biology

(2014) H.-Y. Ho et al.   FREE RADICAL RESEARCH

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

(2014) Rafael Moreno-Sánchez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Changes in gene expression profile in two multidrug resistant cell lines derived from a same drug sensitive cell line

(2014) Miguel Angelo Martins Moreira et al.   LEUKEMIA RESEARCH

Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells

(2014) Gianni Colotti et al.   MOLECULES

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

(2014) H Lincet et al.   ONCOGENE

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms

(2013) Nathalia Daflon-Yunes et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Resistance to PARP-Inhibitors in Cancer Therapy

(2013) Alicia Montoni et al.   Frontiers in Pharmacology

Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells

(2013) Valentina Tosato et al.   Frontiers in Oncology

SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation

(2012) Hyun-Yoo Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

PARPs and the DNA damage response

(2012) F. G. Sousa et al.   CARCINOGENESIS

Subcellular dynamics of multifunctional protein regulation: Mechanisms of GAPDH intracellular translocation

(2012) Michael A. Sirover   JOURNAL OF CELLULAR BIOCHEMISTRY

A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line

(2012) Stephany Correa et al.   Proteome Science

Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning

(2011) Lara Milane et al.   Cancer Cell International

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

GAPDH: A common enzyme with uncommon functions

(2011) Craig Nicholls et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Acquisition of MDR phenotype by leukemic cells is associated with increased caspase-3 activity and a collateral sensitivity to cold stress

(2011) David Cerezo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Multi-modal strategies for overcoming tumor drug resistance: Hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology

(2011) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

Effect of thapsigargin on P-glycoprotein-negative and P-glycoprotein-positive L1210 mouse leukaemia cells

(2010) M. Šereš et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

Modulation of Caspase-Independent Cell Death Leads to Resensitization of Imatinib Mesylate-Resistant Cells

(2009) V. J. Lavallard et al.   CANCER RESEARCH

Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state

(2009) Maria Wartenberg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Caspase-independent cell death: leaving the set without the final cut

(2008) S W G Tait et al.   ONCOGENE