B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2

The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view

(2017) Salah Mohamed El Sayed et al.   MEDICAL HYPOTHESES

New B7 Family Checkpoints in Human Cancers

(2017) Ling Ni et al.   MOLECULAR CANCER THERAPEUTICS

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

(2016) Sangbin Lim et al.   CANCER RESEARCH

Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3

(2016) Cheng-Shi He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation via suppression of HK2-modulated glucose metabolism

(2016) Xin Lv et al.   Molecular Medicine Reports

B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu

(2016) ZHANG ZHANG SUN et al.   ONCOLOGY REPORTS

PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma

(2015) Baobiao Zhuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a

(2015) Ming Liu et al.   CANCER RESEARCH

MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer

(2015) Weijie Guo et al.   HEPATOLOGY

B7-H3 silencing inhibits tumor progression of mantle cell lymphoma and enhances chemosensitivity

(2015) WEI ZHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Diet and colorectal cancer

(2015) Raul Baena et al.   MATURITAS

Quinolone-indolone conjugate induces apoptosis by inhibiting the EGFR-STAT3-HK2 pathway in human cancer cells

(2015) YING-HUA LIU et al.   Molecular Medicine Reports

B7-H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer

(2015) FEN LIU et al.   Molecular Medicine Reports

Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3

(2015) Ting Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

B7-H3 silencing by RNAi inhibits tumor progression and enhances chemosensitivity in U937 cells

(2015) Wei Zhang et al.   OncoTargets and Therapy

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

(2015) Raquel G. Coelho et al.   Oncotarget

Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells

(2015) Abir Mukherjee et al.   NEOPLASIA

Sa1691 MiR-181b-1 Controls Glycolysis As STAT3 Activator in Colon Cancer Cells

(2015) Xiaolin Pan et al.   GASTROENTEROLOGY

B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome

(2014) Vibeke A Ingebrigtsen et al.   BMC CANCER

Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

(2014) Zhengkun Li et al.   CANCER SCIENCE

Overexpression of B7-H3 in CD133+ colorectal cancer cells is associated with cancer progression and survival in human patients

(2014) Zhou Bin et al.   JOURNAL OF SURGICAL RESEARCH

The Warburg effect: molecular aspects and therapeutic possibilities

(2014) Hanh Ngo et al.   MOLECULAR BIOLOGY REPORTS

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

MicroRNA-31 Activates the RAS Pathway and Functions as an Oncogenic MicroRNA in Human Colorectal Cancer by Repressing RAS p21 GTPase Activating Protein 1 (RASA1)

(2013) Defang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells

(2012) Lea H Gregersen et al.   BMC CANCER

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer

(2012) Vibeke Anett Ingebrigtsen et al.   INTERNATIONAL JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Pairwise Chemical Genetic Screen Identifies New Inhibitors of Glucose Transport

(2011) Olesya A. Ulanovskaya et al.   CHEMISTRY & BIOLOGY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influence of chemoresistance and p53 status on fluoro-2-deoxy-d-glucose incorporation in cancer

(2009) Tim A.D. Smith   NUCLEAR MEDICINE AND BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY