A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

A recellularized human colon model identifies cancer driver genes

(2016) Huanhuan Joyce Chen et al.   NATURE BIOTECHNOLOGY

Engineered colons for cancer research

(2016) Iain Dickson   Nature Reviews Gastroenterology & Hepatology

Development of an Advanced Primary HumanIn VitroModel of the Small Intestine

(2016) Matthias Schweinlin et al.   TISSUE ENGINEERING PART C-METHODS

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

A microfluidic cell culture device (μFCCD) to culture epithelial cells with physiological and morphological properties that mimic those of the human intestine

(2015) Meiying Chi et al.   BIOMEDICAL MICRODEVICES

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

(2015) Huanhuan Joyce Chen et al.   NATURE BIOTECHNOLOGY

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cell chips as new tools for cell biology – results, perspectives and opportunities

(2013) Elisabetta Primiceri et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reinventing clinical trials

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

NCATS launches drug repurposing program

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

A living system on a chip

(2011) Monya Baker   NATURE

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro

(2009) Andres I. Roig et al.   GASTROENTEROLOGY

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Differentiation of Neural Progenitor Cells in a Microfluidic Chip-Generated Cytokine Gradient

(2009) Joong Yull Park et al.   STEM CELLS

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Animal Models for Liver Metastases of Colorectal Cancer: Research Review of Preclinical Studies in Rodents

(2008) Gabie M. de Jong et al.   JOURNAL OF SURGICAL RESEARCH

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

(2008) L. Vermeulen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA