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Title
G-quadruplexes: a promising target for cancer therapy
Authors
Keywords
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Journal
Molecular Cancer
Volume 20, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-25
DOI
10.1186/s12943-021-01328-4
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Note: Only part of the references are listed.- Photodynamic Therapy for ras-Driven Cancers: Targeting G-Quadruplex RNA Structures with Bifunctional Alkyl-Modified Porphyrins
- (2020) Annalisa Ferino et al. JOURNAL OF MEDICINAL CHEMISTRY
- The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
- (2020) Peter M. Bruno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Re-epithelialization and immune cell behaviour in an ex vivo human skin model
- (2020) Ana Rakita et al. Scientific Reports
- The regulation and functions of DNA and RNA G-quadruplexes
- (2020) Dhaval Varshney et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
- (2020) Josué Carvalho et al. TRENDS IN MOLECULAR MEDICINE
- The DNA secondary structures at telomeres and genome instability
- (2020) Jun Tan et al. Cell and Bioscience
- A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex
- (2020) Tian-Ying Wu et al. BIOORGANIC CHEMISTRY
- G-Quadruplexes at Telomeres: Friend or Foe?
- (2020) Tracy M. Bryan MOLECULES
- Landscape of G-quadruplex DNA structural regions in breast cancer
- (2020) Robert Hänsel-Hertsch et al. NATURE GENETICS
- Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models
- (2020) Ahmed A. Ahmed et al. ACS Medicinal Chemistry Letters
- A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
- (2020) Bishnu P Paudel et al. eLife
- Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
- (2020) Ewa Paluszkiewicz et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells
- (2020) Ahmed Abdullah Ahmed et al. MOLECULES
- Replication of G Quadruplex DNA
- (2019) Leticia Koch Lerner et al. Genes
- G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
- (2019) Yuxiang Wang et al. Nature Communications
- Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
- (2019) Albino Bacolla et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Whole genome experimental maps of DNA G-quadruplexes in multiple species
- (2019) Giovanni Marsico et al. NUCLEIC ACIDS RESEARCH
- Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
- (2019) Jennifer Beauvarlet et al. NUCLEIC ACIDS RESEARCH
- Binding of BRACO19 to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent
- (2019) Babitha Machireddy et al. MOLECULES
- G-quadruplex forming region within WT1 promoter is selectively targeted by daunorubicin and mitoxantrone: A possible mechanism for anti-leukemic effect of drugs
- (2019) Saeedeh Ghazaey Zidanloo et al. JOURNAL OF BIOSCIENCES
- BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
- (2019) Katharine Herbert et al. GENES & DEVELOPMENT
- Many ways to resistance: How melanoma cells evade targeted therapies
- (2019) Ines Kozar et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species
- (2019) Emilia Puig Lombardi et al. NUCLEIC ACIDS RESEARCH
- Genetic interactions of G-quadruplexes in humans
- (2019) Katherine G Zyner et al. eLife
- Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors
- (2019) Sanjeevani Arora et al. ADVANCES IN THERAPY
- Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
- (2019) Tracy M. Bryan MOLECULES
- Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer
- (2019) Matthew D. Hellmann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutation-Derived Neoantigens for Cancer Immunotherapy
- (2019) John C. Castle et al. Frontiers in Immunology
- Targeting DNA repair in cancer: current state and novel approaches
- (2019) Apostolos Klinakis et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Shedding light on the interaction of polydatin and resveratrol with G-quadruplex and duplex DNA: a biophysical, computational and biological approach
- (2019) Chiara Platella et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands
- (2019) Recagni et al. Cells
- In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
- (2019) Justin J. Montoya et al. BMC CANCER
- Importance of the hydroxyl substituents in the B–ring of plant flavonols on their preferential binding interactions with VEGF G–quadruplex DNA: Multi-spectroscopic and molecular modeling studies
- (2018) Snehasish Bhattacharjee et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Mechanism of Action of G-Quadruplex–Forming Oligonucleotide Homologous to the Telomere Overhang in Melanoma
- (2018) Gagan Chhabra et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
- (2018) Chiara Marchetti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex
- (2018) Ming-Hao Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells
- (2018) Andrea Local et al. MOLECULAR CANCER THERAPEUTICS
- Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
- (2018) Robert Hänsel-Hertsch et al. Nature Protocols
- G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
- (2018) Emanuela Ruggiero et al. NUCLEIC ACIDS RESEARCH
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
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- (2018) Tian Tian et al. Chem
- HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?
- (2018) Jussara Amato et al. CHEMICAL COMMUNICATIONS
- Ligand design to acquire specificity to intended G-quadruplex structures
- (2018) Sefan Asamitsu et al. CHEMISTRY-A EUROPEAN JOURNAL
- Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy
- (2018) Rudradip Pattanayak et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds
- (2018) Alessia Pagano et al. Frontiers in Chemistry
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- (2018) Ushasri Chilakamarthi et al. BIOCHEMISTRY
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- (2018) Mahmoud A. S. Abdelhamid et al. BIOCHEMISTRY
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- (2018) Wenwen Wu et al. CANCER RESEARCH
- DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
- (2018) Alessio De Magis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
- (2018) David R. Calabrese et al. Nature Communications
- Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule
- (2018) Eleonora Zorzan et al. Scientific Reports
- G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide
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- (2017) Qian-Liang Guo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2017) Benoît Bertrand et al. INORGANIC CHEMISTRY
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- (2017) Zhize Ou et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation
- (2017) Giulia Miglietta et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Disubstituted Quindoline Derivatives Inhibiting Burkitt’s Lymphoma Cell Proliferation by Impeding c-MYC Transcription
- (2017) Hui-Yun Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression
- (2017) Christine E. Kaiser et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex
- (2017) Rabindra Das et al. MOLECULES
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- (2017) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2017) Andreas Hochhaus et al. NEW ENGLAND JOURNAL OF MEDICINE
- CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
- (2017) Hong Xu et al. Nature Communications
- KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
- (2017) Andrew M. Waters et al. Cold Spring Harbor Perspectives in Medicine
- KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer
- (2017) Jonas Cicenas et al. Cancers
- The Interplay between G-quadruplex and Transcription
- (2017) Nayun Kim CURRENT MEDICINAL CHEMISTRY
- Identification and characterization of a new G-quadruplex forming region within the kRAS promoter as a transcriptional regulator
- (2016) Rhianna K. Morgan et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- G4 DNA in ras genes and its potential in cancer therapy
- (2016) Susanna Cogoi et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells
- (2016) Emanuela Micheli et al. BIOCHIMIE
- Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
- (2016) Jutta Zimmer et al. MOLECULAR CELL
- G-quadruplex structures mark human regulatory chromatin
- (2016) Robert Hänsel-Hertsch et al. NATURE GENETICS
- A Series of β-Carboline Alkaloids from the Seeds of Peganum harmala Show G-Quadruplex Interactions
- (2016) Kai-Bo Wang et al. ORGANIC LETTERS
- G-Quadruplexes in DNA Replication: A Problem or a Necessity?
- (2016) Anne-Laure Valton et al. TRENDS IN GENETICS
- Downregulation of the WT1 gene expression via TMPyP4 stabilization of promoter G-quadruplexes in leukemia cells
- (2016) Saeedeh Ghazaey Zidanloo et al. TUMOR BIOLOGY
- Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models
- (2016) Eleonora Zorzan et al. Oncotarget
- Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
- (2016) Valentina Cappello et al. Scientific Reports
- Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression
- (2015) Kenneth M. Felsenstein et al. ACS Chemical Biology
- Myc and cell cycle control
- (2015) Gabriel Bretones et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- High-throughput sequencing of DNA G-quadruplex structures in the human genome
- (2015) Vicki S Chambers et al. NATURE BIOTECHNOLOGY
- Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells
- (2015) P-C Chu et al. ONCOGENE
- Somatic mutation in cancer and normal cells
- (2015) I. Martincorena et al. SCIENCE
- Telomeric G-quadruplexes are a substrate and site of localization for human telomerase
- (2015) Aaron L. Moye et al. Nature Communications
- Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX
- (2015) David Clynes et al. Nature Communications
- A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region
- (2015) Yun-Xia Xiong et al. Oncotarget
- A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer
- (2015) Stephan A Ohnmacht et al. Scientific Reports
- Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro
- (2015) Jonathan D. Williams et al. Frontiers in Genetics
- Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative
- (2014) Lijuan Su et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells
- (2014) D. Schiavone et al. EMBO JOURNAL
- DNA and RNA Quadruplex-Binding Proteins
- (2014) Václav Brázda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
- (2014) Hyun-Jin Kang et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies
- (2014) Valentina Rapozzi et al. Molecular Cancer
- RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
- (2014) Andrew L. Wolfe et al. NATURE
- HRASis silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property
- (2014) Susanna Cogoi et al. NUCLEIC ACIDS RESEARCH
- Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues
- (2014) Giulia Biffi et al. PLoS One
- AML cells carrying NPM1 mutation are resistant to nucleophosmin displacement from nucleoli caused by the G-quadruplex ligand TmPyP4
- (2014) A De Cola et al. Cell Death & Disease
- The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds
- (2013) Sheila Mpima et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting a c-MYC G-quadruplex DNA with a fragment library
- (2013) Hamid R. Nasiri et al. CHEMICAL COMMUNICATIONS
- Copper(ii) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA
- (2013) Siti Munira Haidad Ali et al. DALTON TRANSACTIONS
- New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability
- (2013) Jin-Hui He et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells
- (2013) Marialuisa Micco et al. JOURNAL OF MEDICINAL CHEMISTRY
- G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
- (2013) Keith I. E. McLuckie et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Pif1 family helicases suppress genome instability at G-quadruplex motifs
- (2013) Katrin Paeschke et al. NATURE
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- (2013) Sara Chiarella et al. NUCLEIC ACIDS RESEARCH
- MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice
- (2013) Susanna Cogoi et al. NUCLEIC ACIDS RESEARCH
- The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kittranscription and induces apoptosis in K562 cells
- (2013) Fei-Hai Shen et al. PHARMACEUTICAL BIOLOGY
- Phenyl 1,2,3-Triazole-Thymidine Ligands Stabilize G-Quadruplex DNA, Inhibit DNA Synthesis and Potentially Reduce Tumor Cell Proliferation over 3′-Azido Deoxythymidine
- (2013) Jerald Mahesh Kumar et al. PLoS One
- Cancer Immunotherapy
- (2013) J. Couzin-Frankel SCIENCE
- The chromatin remodeller ATRX: a repeat offender in human disease
- (2013) David Clynes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy
- (2013) Libo Yuan et al. Scientific Reports
- Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage
- (2012) Nicola Ivan Orlotti et al. Autophagy
- Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
- (2012) Wei-Jia Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2012) Megan J. Bywater et al. CANCER CELL
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- (2012) H. Ho et al. CANCER RESEARCH
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- (2012) I. A. Prior et al. CANCER RESEARCH
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- (2012) Jean-Baptiste Vannier et al. CELL
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- (2012) Charles Y. Lin et al. CELL
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- (2012) Chi V. Dang CELL
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- (2012) Haoqiang Ying et al. CELL
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- (2012) Marco Franceschin et al. ChemMedChem
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- (2012) Sheng-Rong Liao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2012) Vijeth K. Katapadi et al. GENOMICS
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- (2012) Peda V. L. Boddupally et al. JOURNAL OF MEDICINAL CHEMISTRY
- Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
- (2012) Raphaël Rodriguez et al. Nature Chemical Biology
- DNA secondary structures: stability and function of G-quadruplex structures
- (2012) Matthew L. Bochman et al. NATURE REVIEWS GENETICS
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- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2012) Qian Li et al. NUCLEIC ACIDS RESEARCH
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- (2012) H Ray-David et al. ONCOGENE
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- (2012) Filippo Doria et al. ORGANIC & BIOMOLECULAR CHEMISTRY
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- (2012) Li-Na Zhu et al. PLoS One
- Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
- (2012) Courtney A. Lovejoy et al. PLoS Genetics
- A structural analysis of G-quadruplex/ligand interactions
- (2011) Shozeb M. Haider et al. BIOCHIMIE
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- (2011) Mekala Gunaratnam et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2011) Antonella Peduto et al. BIOORGANIC & MEDICINAL CHEMISTRY
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- (2011) Douglas Hanahan et al. CELL
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- (2011) Mariangela Faudale et al. CHEMICAL COMMUNICATIONS
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- (2011) Judith Lopes et al. EMBO JOURNAL
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- (2011) Yan Ma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) Zeng Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) Robert V. Brown et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Valentina Casagrande et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) Subhajyoti De et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2011) Alexandro Membrino et al. PLoS One
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- (2011) C. M. Heaphy et al. SCIENCE
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- (2010) Sonja M. Hampel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2010) Martin J. Law et al. CELL
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- (2010) John A. Capra et al. PLoS Computational Biology
- Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder
- (2009) Hyun-Jin Kang et al. BIOCHEMISTRY
- Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
- (2009) D. Drygin et al. CANCER RESEARCH
- Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer
- (2009) Stephen Neidle FEBS Journal
- The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts
- (2009) S. Nakken et al. NUCLEIC ACIDS RESEARCH
- Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription
- (2009) Manikandan Paramasivam et al. NUCLEIC ACIDS RESEARCH
- Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
- (2009) Angela Rizzo et al. NUCLEIC ACIDS RESEARCH
- 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc
- (2008) Yan Ma et al. BIOORGANIC & MEDICINAL CHEMISTRY
- G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors
- (2008) C. Leonetti et al. CLINICAL CANCER RESEARCH
- FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
- (2008) Timothy B. C. London et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2008) Susanna Cogoi et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2008) Raphaël Rodriguez et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability
- (2008) Y. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins
- (2008) Susanna Cogoi et al. NUCLEIC ACIDS RESEARCH
- Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes
- (2008) Johanna Eddy et al. NUCLEIC ACIDS RESEARCH
- Stability and kinetics of G-quadruplex structures
- (2008) A. N. Lane et al. NUCLEIC ACIDS RESEARCH
- Antitumor activity of G-quadruplex–interactive agent TMPyP4 in K562 leukemic cells
- (2007) Yoko Mikami-Terao et al. CANCER LETTERS
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