A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

Observation of processive telomerase catalysis using high-resolution optical tweezers

(2020) Eric M. Patrick et al.   Nature Chemical Biology

Human POT1 unfolds G-quadruplexes by conformational selection

(2020) Jonathan B Chaires et al.   NUCLEIC ACIDS RESEARCH

Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells

(2019) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

Telomere DNA G-quadruplex folding within actively extending human telomerase

(2019) Linnea I. Jansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Telomerase with Telomeric DNA

(2018) Jiansen Jiang et al.   CELL

Cryo-EM structure of substrate-bound human telomerase holoenzyme

(2018) Thi Hoang Duong Nguyen et al.   NATURE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

(2018) Michael C. Chen et al.   NATURE

Quantitative assays for measuring human telomerase activity and DNA binding properties

(2017) Christopher G. Tomlinson et al.   METHODS

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

(2017) Hui-Ting Lee et al.   NUCLEIC ACIDS RESEARCH

2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA

(2017) Hala Abou Assi et al.   NUCLEIC ACIDS RESEARCH

A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase

(2016) Jagat B. Budhathoki et al.   BIOPHYSICAL JOURNAL

Telomerase as a Cancer Target. Development of New Molecules

(2016) D.L. Mengual Gomez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases

(2016) Ramreddy Tippana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

(2015) Christopher G. Tomlinson et al.   BIOCHEMICAL JOURNAL

A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

(2015) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESI-MS Investigation of an Equilibrium between a Bimolecular Quadruplex DNA and a Duplex DNA/RNA Hybrid

(2015) Monica L. Birrento et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A DNA-hairpin model for repeat-addition processivity in telomere synthesis

(2015) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

(2015) Aaron L. Moye et al.   Nature Communications

A DNA-hairpin model for repeat-addition processivity in telomere synthesis

(2015) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins

(2014) Helen Hwang et al.   STRUCTURE

Coordinated DNA dynamics during the human telomerase catalytic cycle

(2014) Joseph W. Parks et al.   Nature Communications

Single-Molecule Fluorescence Reveals the Unwinding Stepping Mechanism of Replicative Helicase

(2014) Salman Syed et al.   Cell Reports

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular basis of recognition of quadruplexes human telomere and c-myc promoter by the putative anticancer agent sanguinarine

(2013) Saptaparni Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RPA-Mediated Unfolding of Systematically Varying G-Quadruplex Structures

(2013) Sujay Ray et al.   BIOPHYSICAL JOURNAL

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Kinetic Partitioning Modulates Human Telomere DNA G-Quadruplex Structural Polymorphism

(2013) Xi Long et al.   PLoS One

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication

(2012) Jan Postberg et al.   GENE

G-Quadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?

(2012) Luigi Petraccone et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA

(2012) John M. Nicoludis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advanced Fluorescence Microscopy Techniques—FRAP, FLIP, FLAP, FRET and FLIM

(2012) Hellen C. Ishikawa-Ankerhold et al.   MOLECULES

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Interaction of human telomeric DNA with N- methyl mesoporphyrin IX

(2012) John M. Nicoludis et al.   NUCLEIC ACIDS RESEARCH

Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study

(2012) Jan Palacký et al.   NUCLEIC ACIDS RESEARCH

Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics

(2012) Helen Hwang et al.   STRUCTURE

Accurate Distance Determination of Nucleic Acids via Förster Resonance Energy Transfer: Implications of Dye Linker Length and Rigidity

(2011) Simon Sindbert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

It all comes together at the ends: Telomerase structure, function, and biogenesis

(2011) Joshua D. Podlevsky et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of Kinetic Intermediates in Single-Particle Dwell-Time Distributions

(2010) Daniel L. Floyd et al.   BIOPHYSICAL JOURNAL

G-Quadruplex Hinders Translocation of BLM Helicase on DNA: A Real-Time Fluorescence Spectroscopic Unwinding Study and Comparison with Duplex Substrates

(2010) Jia-quan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3)

(2010) M. Clarke Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation

(2010) Ming-Liang Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fluorescence-based duplex–quadruplex competition test to screen for telomerase RNA quadruplex ligands

(2010) Laurent Lacroix et al.   NUCLEIC ACIDS RESEARCH

InTERTpreting telomerase structure and function

(2010) H. D. M. Wyatt et al.   NUCLEIC ACIDS RESEARCH

Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group

(2009) Siritron Samosorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arrangements of human telomere DNA quadruplex in physiologically relevant K + solutions

(2009) D. Renčiuk et al.   NUCLEIC ACIDS RESEARCH

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

(2008) Andrew J. Gillis et al.   NATURE

A sensitive direct human telomerase activity assay

(2008) Scott B Cohen et al.   NATURE METHODS

Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates

(2008) Katrin Paeschke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Measured and calculated CD spectra of G-quartets stacked with the same or opposite polarities

(2007) Donald M. Gray et al.   CHIRALITY