Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
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Title
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Authors
Keywords
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Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 364, Issue 26, Pages 2507-2516
Publisher
New England Journal of Medicine (NEJM/MMS)
Online
2011-06-05
DOI
10.1056/nejmoa1103782
References
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- BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma.
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- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
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- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
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- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
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- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
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- The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
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- Final Version of 2009 AJCC Melanoma Staging and Classification
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- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
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