A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

The genetic classification of pancreatic neoplasia

(2015) Hanno Matthaei et al.   JOURNAL OF GASTROENTEROLOGY

Thermodynamics of Binding of Di- and Tetrasubstituted Naphthalene Diimide Ligands to DNA G-Quadruplex

(2015) Gary Prato et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A newly identified G-quadruplex as a potential target regulating Bcl-2 expression

(2014) Hongxia Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

(2014) Magdalena Slusarczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

(2014) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues

(2014) Giulia Biffi et al.   PLoS One

Nab-paclitaxel and gemcitabine for the treatment of patients with metastatic pancreatic cancer

(2014) Erkut Borazanci et al.   Expert Review of Gastroenterology & Hepatology

Ruthenium (II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells

(2013) Chuan Wang et al.   BIOMETALS

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

(2013) Marialuisa Micco et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-Quadruplex Structures Formed at the HOX11 Breakpoint Region Contribute to Its Fragility during t(10;14) Translocation in T-Cell Leukemia

(2013) M. Nambiar et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Structural dynamics of possible late-stage intermediates in folding of quadruplex DNA studied by molecular simulations

(2013) P. Stadlbauer et al.   NUCLEIC ACIDS RESEARCH

Anti-Tumour Efficacy of Capecitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer

(2013) Aurélie Courtin et al.   PLoS One

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

(2013) Y Yuan et al.   Cell Death & Disease

Reference Simulations of Noncanonical Nucleic Acids with Different χ Variants of the AMBER Force Field: Quadruplex DNA, Quadruplex RNA, and Z-DNA

(2012) Miroslav Krepl et al.   Journal of Chemical Theory and Computation

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands

(2012) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting pancreatic cancer with a G-quadruplex ligand

(2011) Mekala Gunaratnam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

(2010) Sonja M. Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary

(2009) Milena Sant et al.   EUROPEAN JOURNAL OF CANCER

ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale

(2009) M. J. Harvey et al.   Journal of Chemical Theory and Computation

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

TRAP–LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules

(2008) Julie Reed et al.   ANALYTICAL BIOCHEMISTRY

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CLINICAL CANCER RESEARCH

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B