Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma

NBR 1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system

(2020) Pablo Sánchez‐Martín et al.   EMBO REPORTS

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

(2020) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Impact of mitochondrial DNA mutations in multiple myeloma

(2020) Phuc H. Hoang et al.   Blood Cancer Journal

The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

(2020) Chiara Fucci et al.   Cell Reports

CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma

(2019) Christopher R. Marlein et al.   CANCER RESEARCH

Exosomes in hepatocellular carcinoma: a new horizon

(2019) Rui Chen et al.   Cell Communication and Signaling

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

(2019) Katarzyna Parzych et al.   ONCOGENE

Molecular signatures of multiple myeloma progression through single cell RNA-Seq

(2019) Jin Sung Jang et al.   Blood Cancer Journal

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

(2019) Danielle Harmer et al.   Frontiers in Endocrinology

Recent advances in uncovering the mechanisms contributing to BIRD-2-induced cell death in B-cell cancer cells

(2019) Martijn Kerkhofs et al.   Cell Death & Disease

Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma

(2019) Karen E. Hayes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

(2019) Sandra Elizabeth Torres et al.   eLife

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

(2019) Michael Sze Yuan Low et al.   Cell Reports

The Association of GSTT1, GSTM1, and TNF-α Polymorphisms With the Risk and Outcome in Multiple Myeloma

(2019) Szymon Zmorzyński et al.   Frontiers in Oncology

Proteasome inhibition in multiple myeloma: lessons for other cancers

(2019) Paula Saavedra-García et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resistance to proteasome inhibitors and other targeted therapies in myeloma

(2018) Craig T. Wallington-Beddoe et al.   BRITISH JOURNAL OF HAEMATOLOGY

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

(2018) Yu Sun et al.   CANCER LETTERS

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway

(2018) Na Jin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation

(2018) Iglika G Ivanova et al.   NUCLEIC ACIDS RESEARCH

Metabolic Links between Plasma Cell Survival, Secretion, and Stress

(2018) Wing Y. Lam et al.   TRENDS IN IMMUNOLOGY

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

(2018) Giampaolo Morciano et al.   NEOPLASIA

An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties

(2018) Sandra Loaiza et al.   BIOMATERIALS

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

(2018) Susan E. Logue et al.   Nature Communications

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

(2018) Emma Madden et al.   BIOLOGY OF THE CELL

Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB

(2018) Masanobu Tsubaki et al.   LABORATORY INVESTIGATION

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

(2018) Eva Delbrel et al.   Scientific Reports

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma

(2017) Nicholas Burwick et al.   LEUKEMIA RESEARCH

The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma

(2017) Ronan Le Moigne et al.   MOLECULAR CANCER THERAPEUTICS

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

(2017) Seweryn Mroczek et al.   Nature Communications

Alteration of mitochondrial biogenesis promotes disease progression in multiple myeloma

(2017) Xin Zhan et al.   Oncotarget

Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer

(2017) Tsutomu Tanaka et al.   Oncotarget

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition

(2016) Prahlad V. Raninga et al.   CELL CYCLE

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance

(2016) Jung-Kang Jin et al.   CIRCULATION RESEARCH

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

BH4 domain of Bcl-2 as a novel target for cancer therapy

(2016) Zhiqing Liu et al.   DRUG DISCOVERY TODAY

AQP8 transports NOX2-generated H 2 O 2 across the plasma membrane to promote signaling in B cells

(2016) Milena Bertolotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

(2016) G P Soriano et al.   LEUKEMIA

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Patient population with multiple myeloma and transitions across different lines of therapy in the USA: an epidemiologic model

(2016) Javier Cid Ruzafa et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Oxidative stress and proteasome inhibitors in multiple myeloma

(2016) Brittany C. Lipchick et al.   PHARMACOLOGICAL RESEARCH

Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells

(2016) K K Starheim et al.   Blood Cancer Journal

Predicting the response of multiple myeloma to the proteasome inhibitor Bortezomib by evaluation of the unfolded protein response

(2016) N Nikesitch et al.   Blood Cancer Journal

Comparative proteomic profiling of refractory/relapsed multiple myeloma reveals biomarkers involved in resistance to bortezomib-based therapy

(2016) Dominik Dytfeld et al.   Oncotarget

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells

(2016) Katarzyna Baranowska et al.   Oncotarget

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

(2016) Daniele Tibullo et al.   Oncotarget

Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming

(2016) Irene Riz et al.   Oncotarget

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

(2015) Enrico Milan et al.   Autophagy

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma

(2015) Megan Y Murray et al.   CELL CYCLE

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma

(2015) Bingzong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

(2015) S Jagannathan et al.   LEUKEMIA

Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells

(2015) Masanobu Tsubaki et al.   LEUKEMIA RESEARCH

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress

(2015) K Rajesh et al.   Cell Death & Disease

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

(2015) Prahlad V. Raninga et al.   Oncotarget

Copper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma

(2015) Kelley Salem et al.   Redox Biology

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib

(2014) M. Gambella et al.   HAEMATOLOGICA

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

(2014) Ming Yang et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Hypoxia promotes stem cell-like phenotype in multiple myeloma cells

(2014) B Muz et al.   Blood Cancer Journal

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition

(2014) Sunita Maharjan et al.   Scientific Reports

Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

(2014) Jie Wang et al.   eLife

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Multiple myeloma Leu167Ile (c.499C>A) mutation preventsXBP1mRNA splicing

(2013) Shin Yee Hong et al.   BRITISH JOURNAL OF HAEMATOLOGY

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

(2013) Chungyee Leung-Hagesteijn et al.   CANCER CELL

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Regulatory crosstalk within the mammalian unfolded protein response

(2013) Joseph W. Brewer   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells

(2013) I.S. Song et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells

(2013) YAWARA KAWANO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Antioxidant Status and Oxidative Stress Markers in Pancreatic Cancer and Chronic Pancreatitis

(2013) Jana Kodydkova et al.   PANCREAS

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation

(2013) Ana Paula Dias Demasi et al.   VIRCHOWS ARCHIV

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis

(2013) Shai White-Gilbertson et al.   Frontiers in Genetics

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes

(2012) E. Panzhinskiy et al.   DIABETOLOGIA

The diverse roles of IRF4 in late germinal center B-cell differentiation

(2012) Nilushi S. De Silva et al.   IMMUNOLOGICAL REVIEWS

The establishment of the plasma cell survival niche in the bone marrow

(2012) Van T. Chu et al.   IMMUNOLOGICAL REVIEWS

Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions

(2012) Sebastiano Gangemi et al.   INFLAMMATION RESEARCH

Bone Marrow Microenvironment in Multiple Myeloma Progression

(2012) S. Manier et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation

(2012) Matthew L. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors

(2012) Simone Cenci et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

RNA surveillance is required for endoplasmic reticulum homeostasis

(2012) K. Sakaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

(2012) Sanghwan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

(2011) S. C. W. Ling et al.   HAEMATOLOGICA

Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells

(2011) Cheryl H. Rozanski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

(2011) S K Martin et al.   LEUKEMIA

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Compromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells

(2011) Anne-Sophie Michallet et al.   PLoS One

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

(2010) Fabio Martinon et al.   CURRENT OPINION IN IMMUNOLOGY

Nrf2 Induces Interleukin-6 (IL-6) Expression via an Antioxidant Response Element within the IL-6 Promoter

(2010) Christoph Jan Wruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

(2010) S Colla et al.   LEUKEMIA

The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity

(2010) Aya Nakaya et al.   LEUKEMIA RESEARCH

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

PTP1B: a double agent in metabolism and oncogenesis

(2010) Shu-Chin Yip et al.   TRENDS IN BIOCHEMICAL SCIENCES

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Bortezomib induces canonical nuclear factor- B activation in multiple myeloma cells

(2009) T. Hideshima et al.   BLOOD

Control of HIF-1  Expression by eIF2  Phosphorylation-Mediated Translational Repression

(2009) K. Zhu et al.   CANCER RESEARCH

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

(2009) Yanjun Ma et al.   CELL STRESS & CHAPERONES

BCR-induced superoxide negatively regulates B-cell proliferation and T-cell-independent type 2 Ab responses

(2009) Sabrina M. Richards et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crosstalk signaling between mitochondrial Ca2+ and ROS

(2009) Robert et al.   Frontiers in Bioscience-Landmark

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Study of antioxidant levels in patients with multiple myeloma

(2009) Alpana Sharma et al.   LEUKEMIA & LYMPHOMA

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

(2008) Silvia Nerini-Molteni et al.   BRITISH JOURNAL OF HAEMATOLOGY

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

(2008) Liping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

Bortezomib-Resistant Nuclear Factor- B Activity in Multiple Myeloma Cells

(2008) S. Markovina et al.   MOLECULAR CANCER RESEARCH

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL

Antioxidant status in pediatric acute lymphocytic leukemia (ALL) and solid tumors: The impact of oxidative stress

(2008) Dalia Mazor et al.   PEDIATRIC BLOOD & CANCER

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

(2007) Jennifer N. Gass et al.   MOLECULAR IMMUNOLOGY