Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Liangyun Li, Yihui Bi, Shaoxi Diao, Xiaofeng Li, Tong Yuan, Tao Xu, Cheng Huang, Jun Li
Summary: This review article highlights the role of exosomal lncRNAs in the development of HCC, showing their crucial involvement in the growth and progression of HCC and their potential as therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Veronica Zelli, Chiara Compagnoni, Roberta Capelli, Alessandra Corrente, Mauro Di Vito Nolfi, Francesca Zazzeroni, Edoardo Alesse, Alessandra Tessitore
Summary: Extracellular vesicles (EVs), including exosomes, play crucial roles in hepatocellular carcinoma (HCC) therapy. Exosomal miRNAs carried by EVs are involved in regulating tumor behavior, reshaping tumor microenvironment, and contributing to drug resistance mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunyang Jiang, Xu Li, Bingsheng Sun, Na Zhang, Jing Li, Shijing Yue, Xiaoli Hu
Summary: This study demonstrates the role of ALAHM in tumor-derived extracellular vesicles (EVs) in promoting liver metastasis of lung adenocarcinoma (LUAD) cells. ALAHM enhances the proliferation, invasion, and migration of LUAD cells, and induces hepatocyte secretion of HGF. The findings suggest that LUAD-cell-derived EVs containing ALAHM contribute to the progression of liver metastasis in LUAD.
Review
Biochemistry & Molecular Biology
Andrei Sorop, Diana Constantinescu, Florentina Cojocaru, Anca Dinischiotu, Dana Cucu, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and is often detected late due to its high clinical and biological heterogeneity. Small nanoparticles with an endosomal origin are valuable biomarkers or carriers for novel treatments in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Amir Tiyuri, Shayeste Sadat Baghermanesh, Yasamin Davatgaran-Taghipour, Seyed Sadegh Eslami, Nasibeh Shaygan, Houman Parsaie, Mahmood Barati, Davod Jafari
Summary: This systematic review and meta-analysis found that serum-derived exosomes have a higher diagnostic accuracy for hepatocellular carcinoma (HCC) compared to alpha-fetoprotein (AFP). Exosomal miRNAs and exosomal RNAs+AFP showed the highest sensitivity and specificity, respectively. Combining these two biomarkers in a panel yielded the best diagnostic results.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Oncology
Daniel M. Girardi, Lara P. Sousa, Thiago A. Miranda, Fernanda N. C. Haum, Gabriel C. B. Pereira, Allan A. L. Pereira
Summary: Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis. Recent years have seen significant changes in the treatment options for advanced HCC, including targeted therapy, immunotherapy, and their combinations, leading to improved disease control and overall survival. This review aims to summarize current treatment options and future prospects for advanced HCC.
Review
Engineering, Biomedical
Zhiwei Sun, Jingjing Yang, Hui Li, Chuanxin Wang, Cameron Fletcher, Juan Li, Yao Zhan, Lutao Du, Fenglong Wang, Yanyan Jiang
Summary: Exosomes and nanomaterials have shown great potential in overcoming challenges in bioanalysis. The research progress in utilizing nanomaterials for exosome analysis has advanced significantly, offering promising clinical applications. The future development of this field holds great potential for innovative methods in biomedical research.
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.
Review
Biochemistry & Molecular Biology
Xiaoyu Zhang, Jing Wang, Jing Zhang, Yuwei Tan, Yiming Li, Zhiyong Peng
Summary: This review discusses the mechanisms of action of exosomes derived from different cell sources in acute kidney injury (AKI). It highlights the potential of exosomes in promoting renal tubular cell regeneration and angiogenesis, regulating autophagy, suppressing inflammatory responses and oxidative stress, and preventing fibrosis. It also emphasizes the role of exosomes as potential biomarkers for diagnosing AKI and the development of exosome engineering for clinical use. However, further research is needed to fully understand the specific mechanisms of exosome actions, their delivery pathways to renal tubular cells, and the application of multi-omics research in studying AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Manish Dwivedi, Diya Ghosh, Anwesha Saha, Saba Hasan, Divya Jindal, Hitendra Yadav, Anuradha Yadava, Medha Dwivedi
Summary: Exosomes are special extracellular vesicles in the eukaryotic system, carrying various endogenous molecules crucial for metabolic reactions. They can be used as therapeutic targets for disorders and diagnostic biomarkers for diseases.
Article
Cell Biology
Zeng-Hong Wu, Cheng Li, You-Jing Zhang, Rong Lin
Summary: This study identified atypical signature exosomes for hepatocellular carcinoma (HCC) based on analyses of exosome and online databases, providing potential biomarkers for HCC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Medicinal
Daniel M. Girardi, Jana Priscila M. Pacifico, Fernanda P. L. Guedes de Amorim, Gustavo dos Santos Fernandes, Marcela C. Teixeira, Allan A. L. Pereira
Summary: With the development of immunotherapy and novel targeting agents, the treatment of advanced hepatocellular carcinoma has significantly improved. Treatment regimens involving the combination of immune checkpoint inhibitors and targeted therapies have shown better outcomes.
Review
Oncology
Haoming Xia, Ziyue Huang, Shuqiang Liu, Xudong Zhao, Risheng He, Zhongrui Wang, Wenguang Shi, Wangming Chen, Zhizhou Li, Liang Yu, Peng Huang, Pengcheng Kang, Zhilei Su, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
Summary: Exosomes are small extracellular vesicles that can carry biologically active substances to participate in intercellular communication, with non-coding RNAs having the ability to regulate the cancerous transformation of target cells and remodel the tumor microenvironment. Due to their low immunogenicity and high stability, exosomes can serve as natural vehicles for the delivery of therapeutic RNAs.
FRONTIERS IN ONCOLOGY
(2021)
