Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Authors
Keywords
-
Journal
Frontiers in Endocrinology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-01-09
DOI
10.3389/fendo.2018.00788
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases
- (2018) Michael Lyman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevalence and causes of work disability among working-age U.S. adults, 2011–2013, NHIS
- (2018) Kristina A. Theis et al. Disability and Health Journal
- Soluble and Cell–Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma
- (2018) Mariah L. Farrell et al. Frontiers in Endocrinology
- The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis
- (2017) Heather Fairfield et al. JOURNAL OF CELLULAR PHYSIOLOGY
- MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway
- (2017) Ru-Fang Xiang et al. Cell Death & Disease
- IL-6, IL-8 and TNF-α levels correlate with disease stage in breast cancer patients
- (2017) Yunfeng Ma et al. Advances in Clinical and Experimental Medicine
- IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway
- (2017) Xiongyan Wu et al. Oncotarget
- High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer
- (2017) Estela Maria Silva et al. PLoS One
- Multiple myeloma in the marrow: pathogenesis and treatments
- (2016) Heather Fairfield et al. Annals of the New York Academy of Sciences
- Adipose, Bone, and Myeloma: Contributions from the Microenvironment
- (2016) Michelle M. McDonald et al. CALCIFIED TISSUE INTERNATIONAL
- Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor- B Signaling for Cancer Treatment
- (2016) K. P. Zeligs et al. CLINICAL CANCER RESEARCH
- Histone deacetylase inhibitors in multiple myeloma: from bench to bedside
- (2016) Takeshi Harada et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease
- (2016) Homare Eda et al. JOURNAL OF BONE AND MINERAL RESEARCH
- IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling
- (2016) Yasushi Shintani et al. Journal of Thoracic Oncology
- High serum levels of interleukin-6 in patients with advanced or metastatic colorectal cancer: the effect on the outcome and the response to chemotherapy plus bevacizumab
- (2016) Masayasu Hara et al. SURGERY TODAY
- Role of interleukin-6 in cancer progression and therapeutic resistance
- (2016) Neeraj Kumari et al. TUMOR BIOLOGY
- A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
- (2016) Monica Florio et al. Nature Communications
- Siltuximab (CNTO 328) with lenalidomide, bortezomib and dexamethasone in newly-diagnosed, previously untreated multiple myeloma: an open-label phase I trial
- (2016) J J Shah et al. Blood Cancer Journal
- The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts
- (2016) Siti-Fauziah Hendrayani et al. Oncotarget
- IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse
- (2016) Xiang Li et al. PLoS One
- Interleukin-6 as a Therapeutic Target
- (2015) J.-F. Rossi et al. CLINICAL CANCER RESEARCH
- A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice
- (2015) Casey R. Doucette et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Signaling Pathways Involved in Osteogenesis and Their Application for Bone Regenerative Medicine
- (2015) Astghik Hayrapetyan et al. TISSUE ENGINEERING PART B-REVIEWS
- The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration
- (2015) Jianjun Bi et al. TUMOR BIOLOGY
- Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression
- (2015) Dong Tang et al. TUMOR BIOLOGY
- Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation
- (2015) Zhiqiang Liu et al. Oncotarget
- Brief Report: Tumor Necrosis Factor and Interleukin-6 Differentially Regulate Dkk-1 in the Inflamed Arthritic Joint
- (2015) Nataliya Yeremenko et al. Arthritis & Rheumatology
- A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma
- (2014) Robert Z. Orlowski et al. AMERICAN JOURNAL OF HEMATOLOGY
- Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System
- (2014) Q. Dou et al. CURRENT CANCER DRUG TARGETS
- STAT of the union: Dynamics of distinct tumor-associated macrophage subsets governed by STAT1
- (2014) Eva Van Overmeire et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells
- (2014) Shanshan Wan et al. GASTROENTEROLOGY
- The role of prostaglandin E2 receptor signaling of dendritic cells in rheumatoid arthritis
- (2014) Xiao-Yi Jia et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
- (2014) E. M. Briso et al. JOURNAL OF IMMUNOLOGY
- Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: data from the SAMURAI study
- (2014) Jun Hashimoto et al. Modern Rheumatology
- PGC-1α integrates glucose metabolism and angiogenesis in multiple myeloma cells by regulating VEGF and GLUT-4
- (2014) DEDONG CAO et al. ONCOLOGY REPORTS
- IL-6 Secreted from Senescent Mesenchymal Stem Cells Promotes Proliferation and Migration of Breast Cancer Cells
- (2014) Guo-hu Di et al. PLoS One
- The cellular and molecular origin of tumor-associated macrophages
- (2014) R. A. Franklin et al. SCIENCE
- Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction
- (2013) T Nagasaki et al. BRITISH JOURNAL OF CANCER
- A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
- (2013) Peter M. Voorhees et al. BRITISH JOURNAL OF HAEMATOLOGY
- Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model
- (2013) Keisuke Tanaka et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- The Osteocyte: An Endocrine Cell … and More
- (2013) Sarah L. Dallas et al. ENDOCRINE REVIEWS
- IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro
- (2013) Shoichi Kaneshiro et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Prostaglandin E2-EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation
- (2013) K. Morimoto et al. JOURNAL OF IMMUNOLOGY
- IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
- (2013) Miao-Fen Chen et al. Molecular Cancer
- The role of IL-6 in the radiation response of prostate cancer
- (2013) Chun-Te Wu et al. Radiation Oncology
- Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study
- (2012) Stephanie Finzel et al. ANNALS OF THE RHEUMATIC DISEASES
- Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer
- (2012) N Kozakai et al. BRITISH JOURNAL OF CANCER
- Interleukin-6 signaling pathway in targeted therapy for cancer
- (2012) Yuqi Guo et al. CANCER TREATMENT REVIEWS
- Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells
- (2012) Denis Selimovic et al. CELLULAR SIGNALLING
- Gemcitabine: A Critical Nucleoside for Cancer Therapy
- (2012) D. S. Gesto et al. CURRENT MEDICINAL CHEMISTRY
- Mechanical regulation of signaling pathways in bone
- (2012) William R. Thompson et al. GENE
- IL-6 Receptor Inhibition Positively Modulates Bone Balance in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-Tumor Necrosis Factor Therapy: Biochemical Marker Analysis of Bone Metabolism in the Tocilizumab RADIATE Study (NCT00106522)
- (2012) Morten A. Karsdal et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling
- (2012) Barbara Peruzzi et al. Nature Communications
- Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis
- (2011) L. Yeo et al. ANNALS OF THE RHEUMATIC DISEASES
- Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion
- (2011) Yuan Zhang et al. CANCER LETTERS
- Mechanisms of cancer cell metastasis to the bone: a multistep process
- (2011) Lalit R Patel et al. Future Oncology
- Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: Reduction post-bortezomib monotherapy
- (2011) Evangelos Terpos et al. INTERNATIONAL JOURNAL OF CANCER
- Osteoprotegerin expression in bone marrow by treatment with tocilizumab in rheumatoid arthritis
- (2011) Katsuaki Kanbe et al. RHEUMATOLOGY INTERNATIONAL
- Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
- (2011) Cheryl Jorcyk et al. Cancer Management and Research
- Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress, and induces caspase-dependent cell death in antiestrogen–sensitive and resistant ER+ breast cancer cells
- (2010) Sudharsan Periyasamy-Thandavan et al. Autophagy
- Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice
- (2010) Toshiyuki Kasahara et al. BONE
- A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
- (2010) J-F Rossi et al. BRITISH JOURNAL OF CANCER
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
- (2010) Chisato Miyaura et al. JOURNAL OF BONE AND MINERAL RESEARCH
- STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer
- (2010) Dimitrios Iliopoulos et al. MOLECULAR CELL
- Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
- (2009) Roland Axmann et al. ARTHRITIS AND RHEUMATISM
- Rapid and sustained improvement in bone and cartilage turnover markers with the antiâinterleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: Results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone
- (2009) Patrick Garnero et al. ARTHRITIS AND RHEUMATISM
- CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
- (2009) A. K. Azab et al. BLOOD
- Inflammation and Cancer: IL-6 and STAT3 Complete the Link
- (2009) Jacqueline Bromberg et al. CANCER CELL
- An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation
- (2009) Dimitrios Iliopoulos et al. CELL
- Dickkopf-1: a suitable target for the management of myeloma bone disease
- (2009) Maria Gavriatopoulou et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the Ca2+/Protein Kinase C and Transforming Growth Factor-β/MAPK Signaling Pathways
- (2009) Kerstin Tiedemann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis
- (2009) Bailin Liang et al. Journal of Inflammation-London
- Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
- (2009) Chengcan Yao et al. NATURE MEDICINE
- Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells
- (2009) N J Sullivan et al. ONCOGENE
- Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells
- (2008) T. Ara et al. CANCER RESEARCH
- Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF- B pathways and promotes osteoclastogenesis in human oral cancer cells
- (2008) C.-H. Tang et al. CARCINOGENESIS
- The dual role of IL-6-type cytokines on bone remodeling and bone tumors
- (2008) Frédéric Blanchard et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
- (2008) Katriina Heikkilä et al. EUROPEAN JOURNAL OF CANCER
- Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance
- (2008) S J Veuger et al. ONCOGENE
- IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF- and IL-17
- (2008) M. Hashizume et al. RHEUMATOLOGY
- Interleukin-6 Mediates G0/G1 Growth Arrest in Hepatocellular Carcinoma Through a STAT 3-Dependent Pathway
- (2007) Dairmuid M. Moran et al. JOURNAL OF SURGICAL RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started