The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

(2010) S Colla et al.   LEUKEMIA

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Multiple receptor tyrosine kinases regulate HIF-1α and HIF-2α in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors

(2010) M B Nilsson et al.   ONCOGENE

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1 -Dependent Pathway in Multiple Myeloma

(2009) J. Zhang et al.   CANCER RESEARCH

Suppression of Hypoxia-Inducible Factor 2  Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells

(2009) A. M. Roberts et al.   CANCER RESEARCH

Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1  and -2  in Colon Cancer

(2009) H. Kikuchi et al.   CANCER RESEARCH

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia

(2009) Eleftheria Hatzimichael et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

(2009) S. K. Martin et al.   HAEMATOLOGICA

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

(2009) Maria Galluzzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Reply to C.D. Atkins

(2009) Adam C. Berger et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan

(2009) Y. Hu et al.   MOLECULAR CANCER THERAPEUTICS

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1

(2008) D. H. Shin et al.   BLOOD

Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family

(2008) Andrew M. Evens et al.   BRITISH JOURNAL OF HAEMATOLOGY

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Combination Strategy Targeting the Hypoxia Inducible Factor-1  with Mammalian Target of Rapamycin and Histone Deacetylase Inhibitors

(2008) H. M.W. Verheul et al.   CLINICAL CANCER RESEARCH

Dysregulated angiogenesis in B-chronic lymphocytic leukemia: Morphologic, immunohistochemical, and flow cytometric evidence

(2008) John L Frater et al.   Diagnostic Pathology

Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation

(2008) Alexandra Giatromanolaki et al.   HEMATOLOGICAL ONCOLOGY

PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells

(2008) Sanjeewani T. Palayoor et al.   INTERNATIONAL JOURNAL OF CANCER

Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs

(2008) Jian-Xin Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

(2008) Ling Lu et al.   MICROVASCULAR RESEARCH

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

(2008) Aline Bozec et al.   NATURE