Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

Glucose-Regulated Protein 78 Signaling Regulates Hypoxia-Induced Epithelial–Mesenchymal Transition in A549 Cells

(2019) Ling-Ling Sun et al.   Frontiers in Oncology

Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1

(2019) Hatem Maamoun et al.   Frontiers in Physiology

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

(2019) Rafal Bartoszewski et al.   FASEB JOURNAL

Melatonin ameliorates endoplasmic reticulum stress in N2a neuroblastoma cell hypoxia-reoxygenation injury by activating the AMPK-Pak2 pathway

(2019) Jin Xing et al.   CELL STRESS & CHAPERONES

FABP4 silencing ameliorates hypoxia reoxygenation injury through the attenuation of endoplasmic reticulum stress-mediated apoptosis by activating PI3K/Akt pathway

(2019) Tianming Deng et al.   LIFE SCIENCES

mRNA-to-protein translation in hypoxia

(2019) Nancy T. Chee et al.   Molecular Cancer

miR-34c-5p modulates X-box–binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response

(2019) Sylwia Bartoszewska et al.   FASEB JOURNAL

Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival

(2019) Zhixiong Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

(2019) Solmaz Shirjang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells

(2019) Kishino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress

(2019) Rafal Bartoszewski et al.   FEBS Journal

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

(2019) Shi-Bin Cheng et al.   Cell Death & Disease

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells

(2018) Anna Janaszak-Jasiecka et al.   ANGIOGENESIS

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

(2018) Alban Longchamp et al.   CELL

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

(2018) Mara Livezey et al.   CELL DEATH AND DIFFERENTIATION

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Defective mitochondrial protease LonP1 can cause classical mitochondrial disease

(2018) Bradley Peter et al.   HUMAN MOLECULAR GENETICS

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation

(2018) Iglika G Ivanova et al.   NUCLEIC ACIDS RESEARCH

Intermittent hypoxia induces a metastatic phenotype in breast cancer

(2018) Anna Chen et al.   ONCOGENE

Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

(2018) Huichun Liang et al.   ONCOGENE

Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions

(2018) David Bargiela et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients

(2018) Isaac Almendros et al.   Frontiers in Neurology

LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells

(2018) Lara Gibellini et al.   Frontiers in Oncology

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons

(2018) Halil Tekin et al.   Nature Biomedical Engineering

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

Editorial focus: entering into the non-coding RNA era

(2018) Rafal Bartoszewski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

(2018) Franziska Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

(2018) Eva Delbrel et al.   Scientific Reports

PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells

(2018) Magdalena Gebert et al.   Scientific Reports

High-throughput single-cell transcriptomics on organoids

(2018) Agnieska Brazovskaja et al.   CURRENT OPINION IN BIOTECHNOLOGY

miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia

(2018) Kinga Kochan-Jamrozy et al.   CELLULAR SIGNALLING

miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells

(2017) Rafal Bartoszewski et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury

(2017) Chiara Imarisio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells

(2017) Lixue Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Anastasis and the ER stress response: Solving the paradox of the unfolded protein response in cancer

(2017) Rafael Vincent M. Manalo   MEDICAL HYPOTHESES

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia

(2017) Dae Wui Yoon et al.   Oncotarget

Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats

(2017) Chengcheng Zhang et al.   Scientific Reports

IRE1α/XBP1s branch of UPR links HIF1α activation to mediate ANGII-dependent endothelial dysfunction under particulate matter (PM) 2.5 exposure

(2017) Xiuduan Xu et al.   Scientific Reports

Dynamic mRNA and miRNA expression analysis in response to hypoxia and reoxygenation in the blunt snout bream (Megalobrama amblycephala)

(2017) Shengming Sun et al.   Scientific Reports

Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress

(2016) Yun-peng Li et al.   ACTA PHARMACOLOGICA SINICA

Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs

(2016) Leszek Kalinowski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator

(2016) Rafal Bartoszewski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Redox Paradox: Can Hypoxia Heal Ischemic Hearts?

(2016) Nuno Guimarães-Camboa et al.   DEVELOPMENTAL CELL

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

(2016) Mohammed Bensellam et al.   DIABETOLOGIA

Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury

(2016) WEIKUN JIA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation

(2016) Jia-You Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypoxia as an off switch for gene expression

(2016) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia

(2016) Mohammad Badran et al.   Oxidative Medicine and Cellular Longevity

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells

(2016) Anna Janaszak-Jasiecka et al.   Scientific Reports

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death

(2016) Boxiao Ding et al.   Scientific Reports

ER Stress and Angiogenesis

(2015) François Binet et al.   Cell Metabolism

SalA Attenuates Hypoxia-Induced Endothelial Endoplasmic Reticulum Stress and Apoptosis via Down-Regulation of VLDL Receptor Expression

(2015) Ping Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

(2015) Mohammed Bensellam et al.   DIABETOLOGIA

Targeting the unfolded protein response for disease intervention

(2015) Alexis Rivas et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop

(2015) Sylwia Bartoszewska et al.   FASEB JOURNAL

HIF3α: the little we know

(2015) Linda Ravenna et al.   FEBS Journal

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo

(2015) Quanlu Duan et al.   Journal of Translational Medicine

Angiogenesis in glaucoma filtration surgery and neovascular glaucoma: A review

(2015) Megan Kim et al.   SURVEY OF OPHTHALMOLOGY

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

(2015) S Saveljeva et al.   Cell Death & Disease

Abstract 3532: Hypoxia is a master regulator of Drosha- and Dicer-dependent miRNA biogenesis in cancer

(2015) Rajesha Rupaimoole et al.   CANCER RESEARCH

Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes

(2015) Jiqian Xu et al.   PLoS One

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

miRNA-dependent cross-talk between VEGF and Ang-2 in hypoxia-induced microvascular dysfunction

(2014) Ruibin Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

(2014) Francesco De Pascali et al.   BIOCHEMISTRY

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury

(2014) Sylvain Le Pape et al.   FEBS LETTERS

Hypoxia triggers endothelial endoplasmic reticulum stress and apoptosis via induction of VLDL receptor

(2014) Dan Yang et al.   FEBS LETTERS

Protein Kinase C delta-Mediated Unfolded Protein Response and Necrotic Cell Death Contributes to Ischemia-Reperfusion Induced Injury in Lung Transplantation

(2014) H. Kim et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

GW25-e0717 Lycopene protects cardiomyocytes from hypoxia/reoxygenation injury via attenuating endoplasmic reticulum stress

(2014) Xu Lei et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

(2014) Hery Urra et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

(2014) Zhao Yang et al.   PLoS One

Poster Abstracts

(2014)   TRANSPLANT INTERNATIONAL

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

(2014) Rajesha Rupaimoole et al.   Nature Communications

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization

(2013) Li Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Endoplasmic reticulum stress signaling: the microRNA connection

(2013) Marion Maurel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The impact of hypoxia on cell death pathways

(2013) Colin R. Lenihan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Maintenance of Mitochondrial Oxygen Homeostasis by Cosubstrate Compensation

(2013) Hao Yuan Kueh et al.   BIOPHYSICAL JOURNAL

Regulation of erythropoiesis by hypoxia-inducible factors

(2013) Volker H. Haase   BLOOD REVIEWS

An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2

(2013) Jun Terashima et al.   BMC MOLECULAR BIOLOGY

Hypoxic Activation of the PERK/eIF2  Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

(2013) H. Mujcic et al.   CLINICAL CANCER RESEARCH

Expression of ATF4 and VEGF in chorionic villus tissue in early spontaneous abortion

(2013) Luwei Chai et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2

(2013) Andreas Pollreisz et al.   EXPERIMENTAL EYE RESEARCH

Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions

(2013) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two phases of disulfide bond formation have differing requirements for oxygen

(2013) Marianne Koritzinsky et al.   JOURNAL OF CELL BIOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

(2013) Dan Cojocari et al.   RADIOTHERAPY AND ONCOLOGY

UPR-inducible miRNAs contribute to stressful situations

(2013) Nilesh Chitnis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4

(2012) Chih-Kang Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Redox-Dependent Protein Quality Control in the Endoplasmic Reticulum: Folding to Degradation

(2012) Masatoshi Hagiwara et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxic preconditioning protects microvascular endothelial cells against hypoxia/reoxygenation injury by attenuating endoplasmic reticulum stress

(2012) Xu-Dong Wu et al.   APOPTOSIS

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression

(2012) Céline Loinard et al.   CIRCULATION

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Protein Folding and Quality Control in the ER

(2012) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

Therapeutic Angiogenesis for Treating Cardiovascular Diseases

(2012) Lorenzo Deveza et al.   Theranostics

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational control is a major contributor to hypoxia induced gene expression

(2011) Twan van den Beucken et al.   RADIOTHERAPY AND ONCOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Hypoxia. 2. Hypoxia regulates cellular metabolism

(2010) William W. Wheaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways

(2010) Taras Afonyushkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis

(2010) Emmanouil Kyriakakis et al.   CELLULAR SIGNALLING

Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors

(2010) Li Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

“ER Stress(ed Out)!”: Paneth Cells and Ischemia–Reperfusion Injury of the Small Intestine

(2010) Arthur Kaser et al.   GASTROENTEROLOGY

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of GRP78 on Endothelial Cell Membranes by an ADAM15-Derived Peptide Induces Angiogenesis

(2010) Annat Raiter et al.   JOURNAL OF VASCULAR RESEARCH

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Transcriptional and Post-Transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response

(2010) Ethel R. Pereira et al.   PLoS One

Vascular Responses to Hypoxia and Ischemia

(2009) Gregg L. Semenza   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

ATF4, an ER Stress and Hypoxia-Inducible Transcription Factor and its Potential Role in Hypoxia Tolerance and Tumorigenesis

(2009) Jiangbin Ye et al.   CURRENT MOLECULAR MEDICINE

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

(2009) Twan van den Beucken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response

(2009) Shirin Doroudgar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surviving hypoxia by modulation of mRNA translation rate

(2009) Michael Fähling   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

(2009) Hilda Mujcic et al.   RADIOTHERAPY AND ONCOLOGY

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

(2008) O. V. Oskolkova et al.   BLOOD

The non-haematopoietic biological effects of erythropoietin

(2008) Murat O. Arcasoy   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Hypoxia-inducible factor (HIF)-1  directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

(2008) Z.-B. Han et al.   CARCINOGENESIS

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic reticulum stress response in murine kidney exposed to acute hypobaric hypoxia

(2008) Jayashree Karar et al.   FEBS LETTERS

The Mechanism of Cystic Fibrosis Transmembrane Conductance Regulator Transcriptional Repression during the Unfolded Protein Response

(2008) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational repression during chronic hypoxia is dependent on glucose levels

(2008) J. D. Thomas et al.   RNA