A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

(2011) Yuji Kubota et al.   NATURE CELL BIOLOGY

Cardiac Copper Deficiency Activates a Systemic Signaling Mechanism that Communicates with the Copper Acquisition and Storage Organs

(2010) Byung-Eun Kim et al.   Cell Metabolism

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation

(2010) H. Ishizaki et al.   Disease Models & Mechanisms

Metal Binding Affinities ofArabidopsisZinc and Copper Transporters: Selectivities Match the Relative, but Not the Absolute, Affinities of their Amino-Terminal Domains,

(2009) Matthias Zimmermann et al.   BIOCHEMISTRY

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

(2009) Thierry O. Fischmann et al.   BIOCHEMISTRY

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

(2009) C. Iverson et al.   CANCER RESEARCH

Structural Biology of Copper Trafficking

(2009) Amie K. Boal et al.   CHEMICAL REVIEWS

Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm

(2009) Gazala Khan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Site-Directed Mutagenesis Identifies a Molecular Switch Involved in Copper Sensing by the Histidine Kinase CinS in Pseudomonas putida KT2440

(2009) D. Quaranta et al.   JOURNAL OF BACTERIOLOGY

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

(2009) SinChun Lim et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper Activation of NF-κB Signaling in HepG2 Cells

(2009) Matthew K. McElwee et al.   JOURNAL OF MOLECULAR BIOLOGY

Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms

(2009) Sarah A. Lowndes et al.   MICROVASCULAR RESEARCH

A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal

(2009) Federica Catalanotti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

(2008) Haile Tecle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION

Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases

(2008) Vered Levin-Salomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease

(2008) Michelle L. Turski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

How do bacterial cells ensure that metalloproteins get the correct metal?

(2008) Kevin J. Waldron et al.   NATURE REVIEWS MICROBIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster

(2008) Xiaohua Chen et al.   NUCLEIC ACIDS RESEARCH