Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
Authors
Keywords
-
Journal
Cancers
Volume 12, Issue 12, Pages 3788
Publisher
MDPI AG
Online
2020-12-16
DOI
10.3390/cancers12123788
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Role of HDACs in normal and malignant hematopoiesis
- (2020) Pan Wang et al. Molecular Cancer
- Mitochondrial TCA cycle metabolites control physiology and disease
- (2020) Inmaculada Martínez-Reyes et al. Nature Communications
- Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer
- (2020) Joseph Sia et al. Frontiers in Cell and Developmental Biology
- The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review
- (2020) Hope S. Rugo et al. ADVANCES IN THERAPY
- Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation
- (2020) Roberto Ravasio et al. Science Advances
- Mitochondrial Metabolism as a Target for Cancer Therapy
- (2020) Karthik Vasan et al. Cell Metabolism
- The Significance of Mitochondrial Dysfunction in Cancer
- (2020) Yongde Luo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Heterogeneity of Glucose Transport in Lung Cancer
- (2020) Cesar A. Martinez et al. Biomolecules
- PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships
- (2020) Yinhu Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- TET2 directs mammary luminal cell differentiation and endocrine response
- (2020) Mi Ran Kim et al. Nature Communications
- Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells
- (2019) Yi Fang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic Niche
- (2019) Catherine Vander Linden et al. Frontiers in Oncology
- Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation
- (2019) Jae-Seon Lee et al. EBioMedicine
- Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
- (2019) Giovanni Nassa et al. Science Advances
- Hypoxia induces rapid changes to histone methylation and reprograms chromatin
- (2019) Michael Batie et al. SCIENCE
- Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
- (2019) Helai P. Mohammad et al. NATURE MEDICINE
- SWI/SNF: Complex complexes in genome stability and cancer
- (2019) Cristina Ribeiro-Silva et al. DNA REPAIR
- Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies
- (2019) Nikolas G. Balanis et al. CANCER CELL
- Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression
- (2019) Kayoko Eguchi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A tumor agnostic therapeutic strategy for Hexokinase 1 Null/Hexokinase 2 positive cancers
- (2019) Shili Xu et al. CANCER RESEARCH
- α-Ketoglutarate links p53 to cell fate during tumour suppression
- (2019) John P. Morris et al. NATURE
- The diverse roles of DNA methylation in mammalian development and disease
- (2019) Maxim V. C. Greenberg et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells
- (2019) Ke Tang et al. ONCOGENE
- Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis
- (2019) Sean C. Tompkins et al. Cell Reports
- p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
- (2019) Meng-Hsiung Hsieh et al. Cell Reports
- The synergistic effect of DZ‑NEP, panobinostat and temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
- (2019) Javier De La Rosa et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance
- (2019) Masoud Najafi et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance
- (2019) Catarina Macedo-Silva et al. Genes
- Epigenetic regulation of m6A modifications in human cancer
- (2019) Wei Zhao et al. Molecular Therapy-Nucleic Acids
- Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier
- (2019) Claire L. Bensard et al. Cell Metabolism
- 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- (2019) B. Pajak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
- (2018) Milica Momcilovic et al. CANCER CELL
- Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate CarrierSLC25A11Gene Confer a Predisposition to Metastatic Paragangliomas
- (2018) Alexandre Buffet et al. CANCER RESEARCH
- Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity
- (2018) Lydia W. S. Finley et al. NATURE CELL BIOLOGY
- Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
- (2018) Timothy L. Lochmann et al. Science Translational Medicine
- Vitamin C in Stem Cell Reprogramming and Cancer
- (2018) Luisa Cimmino et al. TRENDS IN CELL BIOLOGY
- Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism
- (2018) Cunqi Ye et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway
- (2018) Lihui Wang et al. Cell Death & Disease
- Metabolic Signaling to the Nucleus in Cancer
- (2018) Sydney L. Campbell et al. MOLECULAR CELL
- Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
- (2018) Xin Sun et al. Epigenetics & Chromatin
- Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity
- (2018) Stéphane Terry et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma
- (2018) Claudio R. Scafoglio et al. Science Translational Medicine
- Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
- (2018) Vera Miranda-Gonçalves et al. Frontiers in Genetics
- Histone Deacetylase Inhibitors as Anticancer Drugs
- (2017) Tomas Eckschlager et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate–Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma
- (2017) Chia-Wen Liu et al. MOLECULAR CANCER THERAPEUTICS
- Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner
- (2017) Konstantinos Dimopoulos et al. Molecular Oncology
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
- (2017) Michalis Agathocleous et al. NATURE
- Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
- (2017) John C. Schell et al. NATURE CELL BIOLOGY
- The impact of cellular metabolism on chromatin dynamics and epigenetics
- (2017) Michael A. Reid et al. NATURE CELL BIOLOGY
- Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis
- (2017) Young Cha et al. NATURE CELL BIOLOGY
- Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments
- (2017) Georg Fluegen et al. NATURE CELL BIOLOGY
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
- (2017) Faizaan Mohammad et al. NATURE MEDICINE
- Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
- (2017) C C Wong et al. ONCOGENE
- DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease
- (2017) Danuta M. Jeziorska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetics in myelodysplastic syndromes
- (2017) Michael Heuser et al. SEMINARS IN CANCER BIOLOGY
- Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l
- (2017) Jinbeom Heo et al. Cell Reports
- KDM4A regulates HIF-1 levels through H3K9me3
- (2017) Grzegorz Dobrynin et al. Scientific Reports
- The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
- (2016) Tom Bender et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
- (2016) Tara TeSlaa et al. Cell Metabolism
- Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
- (2016) In-Young Hwang et al. Cell Metabolism
- Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells
- (2016) Shugo Tohyama et al. Cell Metabolism
- Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
- (2016) Nicolas Reynoird et al. GENES & DEVELOPMENT
- SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells
- (2016) Limei Liu et al. HEPATOLOGY
- Tumour hypoxia causes DNA hypermethylation by reducing TET activity
- (2016) Bernard Thienpont et al. NATURE
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
- (2016) Min Pan et al. NATURE CELL BIOLOGY
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- The molecular hallmarks of epigenetic control
- (2016) C. David Allis et al. NATURE REVIEWS GENETICS
- Mitonuclear communication in homeostasis and stress
- (2016) Pedro M. Quirós et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
- (2016) Amit D. Gujar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic Determinants of Cancer
- (2016) Stephen B. Baylin et al. Cold Spring Harbor Perspectives in Biology
- Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells
- (2016) Adam Collinson et al. Cell Reports
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Mitochondrial pyruvate transport: a historical perspective and future research directions
- (2015) Kyle S. McCommis et al. BIOCHEMICAL JOURNAL
- TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma
- (2015) Naoki Oshimori et al. CELL
- Hypoxia Induces Production of L-2-Hydroxyglutarate
- (2015) Andrew M. Intlekofer et al. Cell Metabolism
- Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
- (2015) William M. Oldham et al. Cell Metabolism
- Exosomes: A Promising Factor Involved in Cancer Hypoxic Microenvironments
- (2015) Y. Yang et al. CURRENT MEDICINAL CHEMISTRY
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
- (2015) Jean-Pierre Etchegaray et al. NATURE CELL BIOLOGY
- RNA-mediated epigenetic regulation of gene expression
- (2015) Daniel Holoch et al. NATURE REVIEWS GENETICS
- Functional expression of sodium-glucose transporters in cancer
- (2015) Claudio Scafoglio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of Chromatin Structure by Long Noncoding RNA
- (2015) Gudrun Böhmdorfer et al. TRENDS IN CELL BIOLOGY
- Methyl-CpG-binding domain proteins: readers of the epigenome
- (2015) Qian Du et al. Epigenomics
- Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters
- (2015) Qiong Wu et al. Oncotarget
- Cancer epigenetics: Now harvesting fruit and seeding for common diseases
- (2014) Toshikazu Ushijima BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chromatin Repressive Complexes in Stem Cells, Development, and Cancer
- (2014) Anne Laugesen et al. Cell Stem Cell
- The emerging roles of DOT1L in leukemia and normal development
- (2014) C M McLean et al. LEUKEMIA
- Unknown
- (2014) Jin Ren et al. MOLECULAR MEDICINE
- Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
- (2014) Bryce W. Carey et al. NATURE
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
- (2013) David B. Shackelford et al. CANCER CELL
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
- (2013) J. Fan et al. Molecular Systems Biology
- The Cancer Genome Atlas Pan-Cancer analysis project
- (2013) John N Weinstein et al. NATURE GENETICS
- The Prognostic Value of p16 Hypermethylation in Cancer: A Meta-Analysis
- (2013) Xiang-Bin Xing et al. PLoS One
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- Chromatin modifications and the DNA damage response to ionizing radiation
- (2013) Rakesh Kumar et al. Frontiers in Oncology
- Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
- (2012) Jueng Soo You et al. CANCER CELL
- A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force
- (2012) S. Beck et al. CANCER RESEARCH
- Metabolic Regulation of Epigenetics
- (2012) Chao Lu et al. Cell Metabolism
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis
- (2012) Alfonso Quintás-Cardama et al. LEUKEMIA RESEARCH
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- BLUEPRINT to decode the epigenetic signature written in blood
- (2012) David Adams et al. NATURE BIOTECHNOLOGY
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone Deacetylase Inhibitors Stimulate Dedifferentiation of Human Breast Cancer Cells Through WNT/β-Catenin Signaling
- (2012) Bisrat G. Debeb et al. STEM CELLS
- HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
- (2011) J. Mathieu et al. CANCER RESEARCH
- Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency
- (2011) R David Hawkins et al. CELL RESEARCH
- Epigenetic aberrations during oncogenesis
- (2011) Maria Hatziapostolou et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells
- (2011) Xiao-Qun Ye et al. INTERNATIONAL JOURNAL OF CANCER
- Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition
- (2011) Min-Zu Wu et al. MOLECULAR CELL
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- (2011) Xiao-Jing Yan et al. NATURE GENETICS
- Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
- (2011) Amparo Wolf et al. NEUROBIOLOGY OF DISEASE
- Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
- (2010) Lisa S. Pike et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sirtuin 1 regulation of developmental genes during differentiation of stem cells
- (2010) V. Calvanese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells
- (2010) Tung-Liang Chung et al. STEM CELLS
- Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
- (2009) N Steele et al. BRITISH JOURNAL OF CANCER
- Epigenetics in cancer
- (2009) S. Sharma et al. CARCINOGENESIS
- Predictive chromatin signatures in the mammalian genome
- (2009) G. C. Hon et al. HUMAN MOLECULAR GENETICS
- Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition
- (2009) A Lakshmikuttyamma et al. ONCOGENE
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- The TET Family of Proteins: Functions and Roles in Disease
- (2009) A. Y. Tan et al. Journal of Molecular Cell Biology
- The human oxygen sensing machinery and its manipulation
- (2008) Rasheduzzaman Chowdhury et al. CHEMICAL SOCIETY REVIEWS
- Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer
- (2008) Alexandros Daskalos et al. INTERNATIONAL JOURNAL OF CANCER
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started