2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma

(2019) Keith A. Michel et al.   RADIOLOGY

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

(2018) Audrey Berthe et al.   BREAST CANCER RESEARCH AND TREATMENT

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

(2018) Marta Lai et al.   INTERNATIONAL JOURNAL OF CANCER

EXTH-07. DESIGN AND EVALUATION OF WP1122, AN INHIBITOR OF GLYCOLYSIS WITH INCREASED CNS UPTAKE.

(2018) Waldemar Priebe et al.   NEURO-ONCOLOGY

Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production

(2017) Ryan Reyes et al.   GENE EXPRESSION

Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo

(2017) Xiaoying Lei et al.   International Journal of Nanomedicine

Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG

(2017) Bhushan S. Pattni et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oxidative phosphorylation: regulation and role in cellular and tissue metabolism

(2017) David F. Wilson   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

(2017) Vera Miranda-Gonçalves et al.   Oncotarget

Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro

(2017) Maruša Bizjak et al.   Scientific Reports

Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin

(2016) Eui Hyun Kim et al.   NEURO-ONCOLOGY

Glucose metabolism-weighted imaging with chemical exchange-sensitive MRI of 2-deoxyglucose (2DG) in brain: Sensitivity and biological sources

(2016) Tao Jin et al.   NEUROIMAGE

Synergistic increase in efficacy of a combination of 2-deoxy-d-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis

(2016) Akansha Jalota et al.   TUMOR BIOLOGY

2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells

(2016) Minoru Tomizawa et al.   Oncology Letters

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

(2016) Huaping Liu et al.   Oncotarget

Targeting hypoxic response for cancer therapy

(2016) Elisa Paolicchi et al.   Oncotarget

Energy disruptors: rising stars in anticancer therapy?

(2016) F Bost et al.   Oncogenesis

Regulation of AMP-activated protein kinase by natural and synthetic activators

(2016) David Grahame Hardie   Acta Pharmaceutica Sinica B

Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells

(2016) Cuicui Gao et al.   PLoS One

Integrating autophagy and metabolism in cancer

(2015) Heesun Cheong   ARCHIVES OF PHARMACAL RESEARCH

2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells

(2015) Ebtihal H Mustafa et al.   Asian Pacific Journal of Cancer Prevention

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog

(2015) Yogesh M. Kulkarni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL

(2015) Yuping Zhang et al.   MEDICAL SCIENCE MONITOR

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

(2015) Ling Li et al.   Redox Biology

2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells

(2015) Shuo-Yu Wang et al.   PLoS One

3-Bromopyruvic Acid, A Hexokinase II Inhibitor, is an Effective Antitumor Agent on the Hepatoma Cells : in vitro and in vivo Findings

(2014) Lei Gong et al.   Anti-Cancer Agents in Medicinal Chemistry

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

The wonders of 2-deoxy-d-glucose

(2014) Haibin Xi et al.   IUBMB LIFE

Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC

(2014) Yu-Yang Pang et al.   LEUKEMIA & LYMPHOMA

Metabolism addiction in pancreatic cancer

(2014) R Blum et al.   Cell Death & Disease

p53 Family and Cellular Stress Responses in Cancer

(2014) Johanna Pflaum et al.   Frontiers in Oncology

Comparison of normal fasting and one-hour glucose levels as predictors of future diabetes during a 34-year follow-up

(2013) Arto Y. Strandberg et al.   ANNALS OF MEDICINE

Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption

(2013) Li-xia Fan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions

(2013) Colin R. Kennedy et al.   CANCER LETTERS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Abstract 2304: 2-DG inhibits of N-glycosylation in glioblastoma-derived cancer stem cells

(2012) Waldemar Priebe et al.   CANCER RESEARCH

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice

(2012) L Goldberg et al.   Cell Death & Disease

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Enzymatic features of the glucose metabolism in tumor cells

(2011) Anique Herling et al.   FEBS Journal

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

(2011) Qilong Wang et al.   PLoS One

2-deoxy-D-glucose combined with ferulic acid enhances radiation response in non-small cell lung carcinoma cells

(2011) Bandugula Reddy et al.   Open Life Sciences

Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

(2010) Caroline Jose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Combining 2-deoxy-D-glucose with electron transport chain blockers: A double-edged sword

(2010) Jean Boutros et al.   CANCER BIOLOGY & THERAPY

2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells

(2010) Damon Shutt et al.   CANCER BIOLOGY & THERAPY

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

2DG enhances the susceptibility of breast cancer cells to doxorubicin

(2010) Iman Ahmad et al.   Open Life Sciences

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centralized Modularity of N-Linked Glycosylation Pathways in Mammalian Cells

(2009) Pan-Jun Kim et al.   PLoS One

Dynamic Near-Infrared Optical Imaging of 2-Deoxyglucose Uptake by Intracranial Glioma of Athymic Mice

(2009) Heling Zhou et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS