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Title
Targeting EZH2 in cancer
Authors
Keywords
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Journal
NATURE MEDICINE
Volume 22, Issue 2, Pages 128-134
Publisher
Springer Nature
Online
2016-02-05
DOI
10.1038/nm.4036
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Note: Only part of the references are listed.- SWI/SNF Chromatin Remodeling and Human Malignancies
- (2015) Julien Masliah-Planchon et al. Annual Review of Pathology-Mechanisms of Disease
- EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
- (2015) Christine M. Fillmore et al. NATURE
- Whole genomes redefine the mutational landscape of pancreatic cancer
- (2015) Nicola Waddell et al. NATURE
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
- (2015) Kimberly H Kim et al. NATURE MEDICINE
- The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
- (2015) Daniel Zingg et al. Nature Communications
- Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
- (2015) Jason S. Kirk et al. Oncotarget
- Ezh2 is required for neural crest-derived cartilage and bone formation
- (2014) D. Schwarz et al. DEVELOPMENT
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- PRC2 loss amplifies Ras signaling in cancer
- (2014) Annika Baude et al. NATURE GENETICS
- Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
- (2014) Carolyn S Lee et al. NATURE GENETICS
- Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
- (2014) Ming Zhang et al. NATURE GENETICS
- Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
- (2014) Sarah K. Knutson et al. PLoS One
- Polycomb Repressive Complex 2 Regulates Lineage Fidelity during Embryonic Stem Cell Differentiation
- (2014) Seraphim R. Thornton et al. PLoS One
- EZH2 expands breast stem cells through activation of NOTCH1 signaling
- (2014) M. E. Gonzalez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
- (2014) Robert Huether et al. Nature Communications
- Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
- (2014) Goro Sashida et al. Nature Communications
- An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
- (2013) Kyle D. Konze et al. ACS Chemical Biology
- EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
- (2013) J. Yan et al. BLOOD
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
- (2013) Eunhee Kim et al. CANCER CELL
- Inhibition of Enhancer of Zeste Homolog 2 (EZH2) Expression Is Associated With Decreased Tumor Cell Proliferation, Migration, and Invasion in Endometrial Cancer Cell Lines
- (2013) Ramez N. Eskander et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
- (2013) Marieta Caganova et al. JOURNAL OF CLINICAL INVESTIGATION
- PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
- (2013) Hae-Yun Jung et al. MOLECULAR CELL
- Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
- (2013) Woojin Kim et al. Nature Chemical Biology
- The mutational landscape of adenoid cystic carcinoma
- (2013) Allen S Ho et al. NATURE GENETICS
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- Transcriptional regulation by Polycomb group proteins
- (2013) Luciano Di Croce et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer
- (2012) G. Ren et al. CANCER RESEARCH
- A687V EZH2 is a gain-of-function mutation found in lymphoma patients
- (2012) Christina R. Majer et al. FEBS LETTERS
- A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
- (2012) C. Simon et al. GENES & DEVELOPMENT
- EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms
- (2012) T Ueda et al. LEUKEMIA
- EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex
- (2012) Ji Min Lee et al. MOLECULAR CELL
- Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- (2012) Trevor J. Pugh et al. NATURE
- Dissecting the genomic complexity underlying medulloblastoma
- (2012) David T. W. Jones et al. NATURE
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
- (2012) Panagiotis Ntziachristos et al. NATURE MEDICINE
- The Role of EZH2 in the Regulation of the Activity of Matrix Metalloproteinases in Prostate Cancer Cells
- (2012) Yong Jae Shin et al. PLoS One
- Dysregulated Recruitment of the Histone Methyltransferase EZH2 to the Class II Transactivator (CIITA) Promoter IV in Breast Cancer Cells
- (2012) Agnieszka D. Truax et al. PLoS One
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
- (2012) Sharad K. Verma et al. ACS Medicinal Chemistry Letters
- Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
- (2012) A. Herrera-Merchan et al. Nature Communications
- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
- (2011) A. M. Jankowska et al. BLOOD
- Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
- (2011) J. Score et al. BLOOD
- FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells
- (2011) Juan Du et al. BREAST CANCER RESEARCH AND TREATMENT
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- EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling
- (2011) Chun-Ju Chang et al. CANCER CELL
- Chromatin Connections to Pluripotency and Cellular Reprogramming
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- Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy
- (2011) C. D. Kemp et al. CLINICAL CANCER RESEARCH
- EZH2 Y641 mutations in follicular lymphoma
- (2011) C Bödör et al. LEUKEMIA
- EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression
- (2011) T. Fan et al. MOLECULAR CANCER RESEARCH
- Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers
- (2011) Shuet Theng Lee et al. MOLECULAR CELL
- The Polycomb complex PRC2 and its mark in life
- (2011) Raphaël Margueron et al. NATURE
- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
- (2011) Yaoting Gui et al. NATURE GENETICS
- Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer
- (2011) H Taniguchi et al. ONCOGENE
- Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2
- (2011) Michiel Smits et al. PLoS One
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition
- (2010) Annette Hayden et al. BREAST CANCER RESEARCH AND TREATMENT
- Regulation of Tumor Angiogenesis by EZH2
- (2010) Chunhua Lu et al. CANCER CELL
- Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
- (2010) Boris G. Wilson et al. CANCER CELL
- Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
- (2010) Martin Sauvageau et al. Cell Stem Cell
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- A unique chromatin signature uncovers early developmental enhancers in humans
- (2010) Alvaro Rada-Iglesias et al. NATURE
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- (2010) Gorica Nikoloski et al. NATURE GENETICS
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB
- (2010) Junxia Min et al. NATURE MEDICINE
- The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer
- (2010) J Yu et al. ONCOGENE
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H3K27ac separates active from poised enhancers and predicts developmental state
- (2010) M. P. Creyghton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
- (2010) L. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance
- (2009) M.-L. Suva et al. CANCER RESEARCH
- Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
- (2009) M. Hussain et al. CANCER RESEARCH
- Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells
- (2009) Elena Ezhkova et al. CELL
- Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation
- (2009) Kairong Cui et al. Cell Stem Cell
- Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
- (2009) B. Schuettengruber et al. DEVELOPMENT
- DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
- (2009) T. B. Miranda et al. MOLECULAR CANCER THERAPEUTICS
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells
- (2009) Xiaojing Yang et al. PLoS One
- Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells
- (2008) Jeongwu Lee et al. CANCER CELL
- Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation
- (2008) Satoshi Fujii et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus
- (2008) S. K. Kia et al. MOLECULAR AND CELLULAR BIOLOGY
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer
- (2008) Q Cao et al. ONCOGENE
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