Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

(2016) Jonathan B. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

(2015) Felix Dietlein et al.   CELL

Emerging roles of lysine methylation on non-histone proteins

(2015) Xi Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor α (TNF-α) Production

(2015) Guiliang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

(2015) Pawel K Mazur et al.   NATURE MEDICINE

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

(2015) Yongjie Wei et al.   eLife

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

(2015) Makoto Nakakido et al.   NEOPLASIA

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer

(2015) Lanxin Liu et al.   Oncotarget

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

(2015) Hyun-Soo Cho et al.   NEOPLASIA

Histone-binding domains: Strategies for discovery and characterization

(2014) Alex W. Wilkinson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis

(2014) Amna Sajjad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

(2014) S Komatsu et al.   BRITISH JOURNAL OF CANCER

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

(2014) Ryuji Hamamoto et al.   CANCER LETTERS

SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor

(2014) Luis Henrique Toshihiro Sakamoto et al.   LEUKEMIA RESEARCH

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells

(2014) Lianhua Piao et al.   NEOPLASIA

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

SMYD2 is induced during cell differentiation and participates in early development

(2013) Borja Sesé et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

(2013) Purvesh Khatri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

(2013) Katherine L Jameson et al.   NATURE MEDICINE

Regulation of estrogen receptor   by histone methyltransferase SMYD2-mediated protein methylation

(2013) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo

(2013) Sandra Morandell et al.   Cell Reports

The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

(2013) Ugo Moens et al.   Genes

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer

(2011) Irina Heid et al.   GASTROENTEROLOGY

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

(2011) Mohamed Abu-Farha et al.   Journal of Molecular Cell Biology

A proteomic approach for the identification of novel lysine methyltransferase substrates

(2011) Dan Levy et al.   Epigenetics & Chromatin

MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin

(2010) Natalia Ronkina et al.   BIOCHEMICAL PHARMACOLOGY

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

(2010) N. Ronkina et al.   NUCLEIC ACIDS RESEARCH

Cardiac Deletion of Smyd2 Is Dispensable for Mouse Heart Development

(2010) Florian Diehl et al.   PLoS One

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

(2009) Shuhei Komatsu et al.   CARCINOGENESIS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Complications in the Assignment of 14 and 28 Da Mass Shift Detected by Mass Spectrometry as in Vivo Methylation from Endogenous Proteins

(2008) Sung Yun Jung et al.   ANALYTICAL CHEMISTRY