Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer

(2018) R J Hartmaier et al.   ANNALS OF ONCOLOGY

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

(2018) Han Chen et al.   CELL

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

(2018) Evangelia K. Papachristou et al.   Nature Communications

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

(2018) Giorgio Giurato et al.   Scientific Data

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

(2018) Pedram Razavi et al.   CANCER CELL

Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer

(2017) Xiaoxue Zhang et al.   Journal of Hematology & Oncology

Mechanisms of Pinometostat (EPZ-5676) Treatment–Emergent Resistance in MLL -Rearranged Leukemia

(2017) Carly T. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

(2017) Eneda Toska et al.   SCIENCE

EnhancerAtlas: a resource for enhancer annotation and analysis in 105 human cell/tissue types

(2016) Tianshun Gao et al.   BIOINFORMATICS

Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

(2016) Sara Kangaspeska et al.   BMC CANCER

Endocrine treatment in breast cancer: Cure, resistance and beyond

(2016) Konstantinos Tryfonidis et al.   CANCER TREATMENT REVIEWS

The many faces of histone H3K79 methylation

(2016) Zeenat Farooq et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer

(2016) Swneke D Bailey et al.   NATURE GENETICS

Functional interdependence of BRD4 and DOT1L in MLL leukemia

(2016) Omer Gilan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional interdependence of BRD4 and DOT1L in MLL leukemia

(2016) Omer Gilan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

(2016) Kamila M. Jozwik et al.   Cell Reports

Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis

(2015) Hao Zeng et al.   GENES & DEVELOPMENT

Progesterone receptor modulates ERα action in breast cancer

(2015) Hisham Mohammed et al.   NATURE

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

(2015) Min-Hyung Cho et al.   Nature Communications

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

(2015) Li Zhang et al.   Oncotarget

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

(2014) Qin Feng et al.   CELL RESEARCH

Absent, Small or Homeotic 2-like Protein (ASH2L) Enhances the Transcription of the Estrogen Receptor α Gene through GATA-binding Protein 3 (GATA3)

(2014) Jin Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis

(2014) Ville Härmä et al.   PLoS One

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

(2014) Sankari Nagarajan et al.   Cell Reports

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

(2013) Wenbo Li et al.   NATURE

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

(2013) Liuqing Yang et al.   NATURE

UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks

(2013) Ravi Kiran Reddy Kalathur et al.   NUCLEIC ACIDS RESEARCH

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

(2013) Hisham Mohammed et al.   Cell Reports

GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

(2012) V. Theodorou et al.   GENOME RESEARCH

Molecular Mechanisms of Selective Estrogen Receptor Modulator Activity in Human Breast Cancer Cells: Identification of Novel Nuclear Cofactors of Antiestrogen–ERα Complexes by Interaction Proteomics

(2012) Francesca Cirillo et al.   JOURNAL OF PROTEOME RESEARCH

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

(2012) Wenyu Yu et al.   Nature Communications

Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer

(2011) Tokiko Ito et al.   BREAST CANCER RESEARCH AND TREATMENT

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

PINA v2.0: mining interactome modules

(2011) Mark J. Cowley et al.   NUCLEIC ACIDS RESEARCH

Estrogen Receptor α Controls a Gene Network in Luminal-Like Breast Cancer Cells Comprising Multiple Transcription Factors and MicroRNAs

(2010) Luigi Cicatiello et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Identification of a Hormone-regulated Dynamic Nuclear Actin Network Associated with Estrogen Receptor α in Human Breast Cancer Cell Nuclei

(2010) Concetta Ambrosino et al.   MOLECULAR & CELLULAR PROTEOMICS

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

FOXA1 is a key determinant of estrogen receptor function and endocrine response

(2010) Antoni Hurtado et al.   NATURE GENETICS

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS

(2010) Roberta Tarallo et al.   PROTEOMICS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY