SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells

Ubiquitinated Sirtuin 1 (SIRT1) Function Is Modulated during DNA Damage-induced Cell Death and Survival

(2015) Lirong Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming

(2015) Wen-Li Mu et al.   STEM CELLS

Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

(2014) Grant A. Challen et al.   Cell Stem Cell

Dual role of SIRT1 in UVB-induced skin tumorigenesis

(2014) M Ming et al.   ONCOGENE

SIRT1 Directly Regulates SOX2 to Maintain Self-Renewal and Multipotency in Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Dong Suk Yoon et al.   STEM CELLS

1B50-1, a mAb Raised against Recurrent Tumor Cells, Targets Liver Tumor-Initiating Cells by Binding to the Calcium Channel α2δ1 Subunit

(2013) Wei Zhao et al.   CANCER CELL

Histone deacetylase 3 participates in self-renewal of liver cancer stem cells through histone modification

(2013) Chungang Liu et al.   CANCER LETTERS

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

Sorting out functions of sirtuins in cancer

(2013) M Roth et al.   ONCOGENE

Oct4 Maintains the Pluripotency of Human Embryonic Stem Cells by Inactivating p53 Through Sirt1-Mediated Deacetylation

(2013) Zhen-Ning Zhang et al.   STEM CELLS

NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells

(2012) Keiko Matsui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

(2012) V. Leko et al.   BLOOD

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

(2012) Juanjuan Shan et al.   HEPATOLOGY

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

(2012) Kyu Yun Jang et al.   PLoS One

Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways

(2012) Yin Lau Lee et al.   PLoS One

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

JNK2-dependent regulation of SIRT1 protein stability

(2011) Jack Ford et al.   CELL CYCLE

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

(2011) Zhanguo Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities

(2011) L. Peng et al.   MOLECULAR AND CELLULAR BIOLOGY

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

(2010) X. Ou et al.   BLOOD

CD13 is a therapeutic target in human liver cancer stem cells

(2010) Naotsugu Haraguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

(2008) Zhen Fan Yang et al.   CANCER CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE