KDM4A regulates HIF-1 levels through H3K9me3

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

(2017) Akane Kawamura et al.   Nature Communications

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1

(2016) Tae-Dong Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

(2015) C. C. Thinnes et al.   CHEMICAL COMMUNICATIONS

HIF3α: the little we know

(2015) Linda Ravenna et al.   FEBS Journal

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

(2015) Joshua C. Black et al.   GENES & DEVELOPMENT

H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

(2015) M M Olcina et al.   ONCOGENE

Targeting histone lysine methylation in cancer

(2015) John McGrath et al.   PHARMACOLOGY & THERAPEUTICS

In VitroRadiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797

(2015) Selvakumar Anbalagan et al.   RADIATION RESEARCH

Epigenetic regulation by histone demethylases in hypoxia

(2015) Rebecca L Hancock et al.   Epigenomics

Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia

(2015) Shaliny Ramachandran et al.   Genes

Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistance

(2014) Lin-Hai Yan et al.   BMC CANCER

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

(2013) Joshua C. Black et al.   CELL

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

(2013) Monica M. Olcina et al.   MOLECULAR CELL

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

(2013) Richard J. Hopkinson et al.   Chemical Science

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

(2013) Lei Wang et al.   Nature Communications

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

(2011) Lars Hillringhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein

(2011) Capucine Van Rechem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

(2011) Tae-Dong Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro

(2011) Bei-Xu Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparagine β-hydroxylation stabilizes the ankyrin repeat domain fold

(2008) Leanne Kelly et al.   Molecular BioSystems