Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Published 2019 View Full Article

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Title
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis
Authors
Keywords
cancer, glutamine, glutathione, hepatocellular carcinoma, metabolomics, liver, Mitochondrial Pyruvate Carrier, stable isotope tracing, synthetic lethality
Journal
Cell Reports
Volume 28, Issue 10, Pages 2608-2619.e6
Publisher
Elsevier BV
Online
2019-09-03
DOI
10.1016/j.celrep.2019.07.098

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