In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice

It’s all about tau

(2019) Cheril Tapia-Rojas et al.   PROGRESS IN NEUROBIOLOGY

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

(2019) Yoshiyuki Soeda et al.   JOURNAL OF ALZHEIMERS DISEASE

O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease

(2019) Philip Ryan et al.   ACS Chemical Neuroscience

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

(2019) Harold G. Selnick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease

(2019) Clarissa Ferolla Mendonça et al.   NEUROBIOLOGY OF DISEASE

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

(2018) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Chronic white matter degeneration, but no tau pathology at 1-year post-repetitive mild traumatic brain injury in tau transgenic model.

(2018) Benoit Christian Mouzon et al.   JOURNAL OF NEUROTRAUMA

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

(2018) Kun Zhang et al.   Neural Regeneration Research

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

(2018) Alice Bittar et al.   npj Vaccines

Methods for Measuring Tau Pathology in Transgenic Mouse Models

(2018) Stefanie K. Forest et al.   JOURNAL OF ALZHEIMERS DISEASE

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

(2018) Andrew J. Aschenbrenner et al.   NEUROLOGY

Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5

(2018) Daijiro Yanagisawa et al.   PLoS One

Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

(2018) Petr Novak et al.   Frontiers in Neuroscience

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8

(2017) Michiaki Okuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study

(2017) Scott A. Ferguson et al.   Frontiers in Aging Neuroscience

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

(2017) Wen Hu et al.   Frontiers in Aging Neuroscience

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

SMALL MOLECULE TAU OLIGOMERIZATION INHIBITORS

(2016) James G. Moe et al.   Alzheimers & Dementia

Tau neurotoxicity and rescue in animal models of human Tauopathies

(2016) Lars Krüger et al.   CURRENT OPINION IN NEUROBIOLOGY

Evaluation of preclinical formulations for a poorly water-soluble compound

(2016) Anna-Karin Granath et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Increased basal ganglia binding of18F-AV-1451 in patients with progressive supranuclear palsy

(2016) Ruben Smith et al.   MOVEMENT DISORDERS

Detecting tau in serum of transgenic animal models after tau immunotherapy treatment

(2016) Cristina d'Abramo et al.   NEUROBIOLOGY OF AGING

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

(2015) Marcos J. Guerrero-Muñoz et al.   Frontiers in Cellular Neuroscience

PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

(2015) Michiaki Okuda et al.   PLoS One

DRUG DEVELOPMENT OF INHIBITORS OF TAU OLIGOMER FORMATION FOR ALZHEIMER'S DISEASE AND TAUOPATHIES

(2014) James G. Moe et al.   Alzheimers & Dementia

Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau

(2014) Naruhiko Sahara et al.   Frontiers in Neurology

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease

(2013) Bruno Bulic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity

(2013) Cristina d’Abramo et al.   PLoS One

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

(2012) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models

(2012) Christopher M. Acker et al.   NEUROBIOLOGY OF AGING

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Modulation of synaptic function by extracellular tau enriched in oligomers

(2009) James G. Moe et al.   Alzheimers & Dementia

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE