Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

Role of Mitochondrial Amyloid-β in Alzheimer's Disease

(2017) John Xi Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells

(2011) Qing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Systems biology of Alzheimer's disease: How diverse molecular changes result in memory impairment in AD

(2011) Gábor Juhász et al.   NEUROCHEMISTRY INTERNATIONAL

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Role of Reactive Oxygen Species and Redox in Regulating the Function of Transient Receptor Potential Channels

(2010) Michael Y. Song et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

(2010) Pavel F. Pavlov et al.   FASEB JOURNAL

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

(2010) M. Soler-Lopez et al.   GENOME RESEARCH

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Functional characterization of the promoter of the human Lon protease gene

(2010) Marcello Pinti et al.   MITOCHONDRION

A New Story about an Old Guy: Is Alzheimer’s Disease Infectious

(2010) Helton J. Reis et al.   Neurodegenerative Diseases

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unveiling the role of network and systems biology in drug discovery

(2010) Albert Pujol et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

A network medicine approach to human disease

(2009) Andreas Zanzoni et al.   FEBS LETTERS

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

(2009) Pavel F. Pavlov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

(2009) Renata Sano et al.   MOLECULAR CELL

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

(2009) Toshiyuki Nakamura et al.   Molecular Neurodegeneration

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Tau hyperphosphorylation affects Smad 2/3 translocation

(2009) S. Baig et al.   NEUROSCIENCE

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease

(2008) Dabing Li et al.   HIPPOCAMPUS

Genomic convergence to identify candidate genes for Alzheimer Disease on chromosome 10

(2008) Xueying Liang et al.   HUMAN MUTATION

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Mitochondrial Ca2+ signalling in hippocampal neurons

(2007) Kenneth W. Young et al.   CELL CALCIUM