Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

Myelin changes at the early stage of 5XFAD mice

(2018) Lihua Gu et al.   BRAIN RESEARCH BULLETIN

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology

(2018) Christopher J. Holler et al.   JOURNAL OF ALZHEIMERS DISEASE

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models

(2018) Pierre De Rossi et al.   BRAIN PATHOLOGY

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

(2017) Idir Malki et al.   FEBS Journal

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

(2017) Robert J. Andrew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease

(2016) Olav M. Andersen et al.   ACTA NEUROPATHOLOGICA

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

(2016) Seonjoo Lee et al.   ANNALS OF NEUROLOGY

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

(2016) Florent Ubelmann et al.   EMBO REPORTS

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

(2016) Toji Miyagawa et al.   HUMAN MOLECULAR GENETICS

Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology

(2016) Stephanie L. Adams et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

(2016) Pierre De Rossi et al.   Molecular Neurodegeneration

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

(2016) P De Rossi et al.   MOLECULAR PSYCHIATRY

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

(2015) Katherine R Sadleir et al.   Molecular Neurodegeneration

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Amphiphysin 2 (BIN1) in physiology and diseases

(2014) Ivana Prokic et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of  -Amyloid by Cells Other Than Excitatory Neurons

(2014) K. Veeraraghavalu et al.   JOURNAL OF NEUROSCIENCE

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

(2014) Virginie Buggia-Prévot et al.   Molecular Neurodegeneration

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

(2014) Kunihiko Kanatsu et al.   Nature Communications

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

(2014) Virginie Buggia-Prévot et al.   Cell Reports

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

(2013) Ming-Hsuan Ou-Yang et al.   Journal of Neuroinflammation

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging

(2013) Elizabeth B. C. Glennon et al.   PLoS One

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

(2013) Patrizia Giannoni et al.   Frontiers in Aging Neuroscience

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

(2011) Ping Gong et al.   Molecular Neurodegeneration

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Synaptic Activity Reduces Intraneuronal A , Promotes APP Transport to Synapses, and Protects against A -Related Synaptic Alterations

(2009) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

(2008) Haipeng Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis

(2008) Michael Rohe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

(2008) S. E. Dodson et al.   JOURNAL OF NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON