N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease

(2018) Cornelia M. Weyand et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Metabolism as a Target for Modulation in Autoimmune Diseases

(2018) Nick Huang et al.   TRENDS IN IMMUNOLOGY

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

(2017) Zhenke Wen et al.   Science Translational Medicine

Review: Metabolic Control of Immune System Activation in Rheumatic Diseases

(2017) Andras Perl   Arthritis & Rheumatology

Myristoylation: An Important Protein Modification in the Immune Response

(2017) Daniel Ikenna Udenwobele et al.   Frontiers in Immunology

Lipid droplets, lipophagy, and beyond

(2016) Chao-Wen Wang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

Metabolic control of arthritis: Switch pathways to treat

(2016) George C. Tsokos   Science Translational Medicine

N-myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum

(2015) Elzbieta Dudek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N -myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level

(2015) Hikaru Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

(2015) Jiyong Liang et al.   Nature Communications

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Requirement of N-Myristoyltransferase 1 in the Development of Monocytic Lineage

(2014) A. Shrivastav et al.   JOURNAL OF IMMUNOLOGY

Serine-threonine kinases in TCR signaling

(2014) María N Navarro et al.   NATURE IMMUNOLOGY

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

T-cell aging in rheumatoid arthritis

(2013) Cornelia M. Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK and Raptor: Matching Cell Growth to Energy Supply

(2008) D. Grahame Hardie   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL