Palmitoylation is required for TNF-R1 signaling

Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle

(2018) Sang Joon Won et al.   ACS Chemical Biology

Caveolae-mediated effects of TNF-α on human skeletal muscle cells

(2018) Elise Dargelos et al.   EXPERIMENTAL CELL RESEARCH

The anticonvulsive Phenhydan® suppresses extrinsic cell death

(2018) Caroline Moerke et al.   CELL DEATH AND DIFFERENTIATION

Herpes simplex virus 1 ICP6 impedes TNF receptor 1–induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles

(2018) Mohammad Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A toolbox for the immunomagnetic purification of signaling organelles

(2018) Jürgen Fritsch et al.   TRAFFIC

ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor

(2017) Andrew T. Holdbrooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues

(2017) Michael W. Beck et al.   Chemical Science

Endocytic regulation of cytokine receptor signaling

(2016) Jaroslaw Cendrowski et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling

(2016) Jyoti Chhibber-Goel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

Changes in lipid raft proteome upon TNF-α stimulation of cystic fibrosis cells

(2016) C. Chhuon et al.   Journal of Proteomics

A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling

(2016) Rahul S Kathayat et al.   Nature Chemical Biology

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death

(2016) Jürgen Fritsch et al.   Oncotarget

Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

(2016) Igor Vujic et al.   Oncotarget

Palmitoylated APP Forms Dimers, Cleaved by BACE1

(2016) Raja Bhattacharyya et al.   PLoS One

Enzymatic protein depalmitoylation by acyl protein thioesterases

(2015) David T.S. Lin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of N-Glycan modification of TNFR1 in inflammatory microglia activation

(2015) Lijian Han et al.   GLYCOCONJUGATE JOURNAL

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

Mechanistic effects of protein palmitoylation and the cellular consequences thereof

(2014) Sanja Blaskovic et al.   CHEMISTRY AND PHYSICS OF LIPIDS

New links betweenS-acylation and cancer

(2014) Jennifer Greaves et al.   JOURNAL OF PATHOLOGY

Cell Fate Decisions Regulated by K63 Ubiquitination of Tumor Necrosis Factor Receptor 1

(2014) J. Fritsch et al.   MOLECULAR AND CELLULAR BIOLOGY

Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle

(2014) Jennifer S. Moylan et al.   Redox Biology

Epicocconone staining: A powerful loading control for Western blots

(2013) Christian P. Moritz et al.   PROTEOMICS

Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization

(2013) M Ali et al.   Cell Death & Disease

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

(2012) Marjorie Poggi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin  6 1 in Glioblastoma

(2012) P. Huang et al.   CANCER RESEARCH

Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4

(2012) Chandan Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells

(2011) Alessio D.’Alessio et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death

(2010) Aurélie Rossin et al.   EXPERIMENTAL CELL RESEARCH

A novel role of microtubular cytoskeleton in the dynamics of caspase-dependent Fas/CD95 death receptor complexes during apoptosis

(2010) Eszter Doma et al.   FEBS LETTERS

Targeting of Tumor Necrosis Factor Receptor 1 to Low Density Plasma Membrane Domains in Human Endothelial Cells

(2010) Alessio D'Alessio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Cholesterol level determines viability and mitogenicity, but it does not affect sodium butyrate-dependent sensitization of Colo 205 cells to TNF-α-induced apoptosis

(2010) Orzechowski   ONCOLOGY REPORTS

Palmitoylation of human FasL modulates its cell death-inducing function

(2010) F Guardiola-Serrano et al.   Cell Death & Disease

Alix and ALG-2 make a link between endosomes and neuronal death

(2009) Anne-Laure Mahul-Mellier et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Palmitoyl protein thioesterase 1 modulates tumor necrosis factor α-induced apoptosis

(2009) Claudine Tardy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional analysis of the posttranslational modifications of the death receptor 6

(2009) Martin Klíma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

(2009) Benjamin Yazdanpanah et al.   NATURE

Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture

(2009) Michael T Forrester et al.   NATURE BIOTECHNOLOGY

The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase

(2009) S. Philipp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

(2008) Aurélie Rossin et al.   BIOCHEMICAL JOURNAL

CARP-2 Is an Endosome-Associated Ubiquitin Ligase for RIP and Regulates TNF-Induced NF-κB Activation

(2008) Wentao Liao et al.   CURRENT BIOLOGY

Palmitoylation of membrane proteins (Review)

(2008) Julie Charollais et al.   MOLECULAR MEMBRANE BIOLOGY

CSS-Palm 2.0: an updated software for palmitoylation sites prediction

(2008) J. Ren et al.   PROTEIN ENGINEERING DESIGN & SELECTION