Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

Inflammatory networks underlying colorectal cancer

(2016) Audrey Lasry et al.   NATURE IMMUNOLOGY

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Relevance and Therapeutic Potential of the Hypusine Modification System

(2015) Nora Pällmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell

(2015) Leonor Miller-Fleming et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

(2015) Christian Schmidt et al.   NUCLEIC ACIDS RESEARCH

High-Precision Analysis of Translational Pausing by Ribosome Profiling in Bacteria Lacking EFP

(2015) Christopher J. Woolstenhulme et al.   Cell Reports

Overexpression of Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Correlates with Cell Aggressiveness and Poor Survival in Gastric Cancer

(2015) Qing-Bin Meng et al.   PLoS One

Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a “humanized” transgenic mouse model of type 1 diabetes

(2014) Shahnawaz Imam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A

(2014) Serafina Oliverio et al.   AMINO ACIDS

EIF5A2 predicts outcome in localised invasive bladder cancer and promotes bladder cancer cell aggressiveness in vitro and in vivo

(2014) J-H Wei et al.   BRITISH JOURNAL OF CANCER

A Hypusine-eIF5A-PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer

(2014) K. Fujimura et al.   CANCER RESEARCH

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

(2014) H. Sievert et al.   Disease Models & Mechanisms

SNS01-T Modulation of eIF5A Inhibits B-cell Cancer Progression and Synergizes With Bortezomib and Lenalidomide

(2014) Sarah M Francis et al.   MOLECULAR THERAPY

Genome-Wide Analyses and Functional Classification of Proline Repeat-Rich Proteins: Potential Role of eIF5A in Eukaryotic Evolution

(2014) Ajeet Mandal et al.   PLoS One

Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

(2014) A. G. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients

(2014) Andrea Bandino et al.   CELLULAR ONCOLOGY

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2

(2014) Guodong Xu et al.   BMC Pulmonary Medicine

Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies

(2013) Mark D. Minden et al.   AMERICAN JOURNAL OF HEMATOLOGY

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

(2013) Elisabeth Mémin et al.   CANCER RESEARCH

(R)-β-Lysine-modified Elongation Factor P Functions in Translation Elongation

(2013) Tammy J. Bullwinkle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

(2013) Berrin Tunca et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

(2013) Catherine A Taylor et al.   Molecular Cancer

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Regulation of Expression of Deoxyhypusine Hydroxylase (DOHH), the Enzyme That Catalyzes the Activation of eIF5A, by miR-331-3p and miR-642-5p in Prostate Cancer Cells

(2012) Michael R. Epis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine

(2012) Tai-An Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modulation of eIF5A Expression Using SNS01 Nanoparticles Inhibits NF-κB Activity and Tumor Growth in Murine Models of Multiple Myeloma

(2012) Catherine A Taylor et al.   MOLECULAR THERAPY

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Expression of Eukaryotic Initiation Factor 5A and Hypusine Forming Enzymes in Glioblastoma Patient Samples: Implications for New Targeted Therapies

(2012) Michael Preukschas et al.   PLoS One

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

(2011) Kazuhiro Nishimura et al.   AMINO ACIDS

Wnt Inhibitor Screen Reveals Iron Dependence of  -Catenin Signaling in Cancers

(2011) S. Song et al.   CANCER RESEARCH

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

(2011) Andrew T. Templin et al.   CELL CYCLE

Post-translational Modification by β-Lysylation Is Required for Activity of Escherichia coli Elongation Factor P (EF-P)

(2011) Jong-Hwan Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway

(2011) Y Luo et al.   ONCOGENE

Update on Iron Chelators in Thalassemia

(2011) E. J. Neufeld   Hematology-American Society of Hematology Education Program

Ciclopirox

(2010) Alessandro Subissi et al.   DRUGS

The antitumor activity of the fungicide ciclopirox

(2010) Hongyu Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients

(2010) Li-Ru He et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

(2009) Y. Eberhard et al.   BLOOD

Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma

(2009) Dong-Jiang Tang et al.   HEPATOLOGY

miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer

(2009) Michael R. Epis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Spermidine/spermine-N1-acetyltransferase: a key metabolic regulator

(2008) Anthony E. Pegg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma

(2008) Guo-Fen Yang et al.   GYNECOLOGIC ONCOLOGY

Eukaryotic Translation Initiation Factor 5A Small Interference RNA–Liposome Complexes Reduce Inflammation and Increase Survival in Murine Models of Severe Sepsis and Acute Lung Injury

(2008) Christopher C. Moore et al.   JOURNAL OF INFECTIOUS DISEASES