Nutrients and Pathways that Regulate Health Span and Life Span

Regulation of Skeletal Muscle Function by Amino Acids

(2020) Yasutomi Kamei et al.   Nutrients

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

(2020) Yizhou Jiang et al.   Cells

The road ahead for health and lifespan interventions

(2020) Marta Gonzalez-Freire et al.   AGEING RESEARCH REVIEWS

Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes

(2020) Stefania D'Adamo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling Pathways That Control Muscle Mass

(2020) Anna Vainshtein et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Do the microRNAs we eat affect gene expression?

(2020) Kristina Campbell   NATURE

Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

(2020) Sina Naghshi et al.   BMJ-British Medical Journal

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

(2020) Kelly Jin et al.   PLoS Genetics

Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience

(2020) Maria C. Perez-Matos et al.   PLoS Genetics

Association Between Plant and Animal Protein Intake and Overall and Cause-Specific Mortality

(2020) Jiaqi Huang et al.   JAMA Internal Medicine

A MicroRNA Linking Human Positive Selection and Metabolic Disorders

(2020) Lifeng Wang et al.   CELL

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective

(2019) Giovanni Vitale et al.   Frontiers in Endocrinology

Fibroblast growth factor 21 controls mitophagy and muscle mass

(2019) Lynette J. Oost et al.   Journal of Cachexia Sarcopenia and Muscle

Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA Damage

(2019) Cristian Del Bo' et al.   Nutrients

mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars

(2019) Gemma Sangüesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Red meat, processed meat, and other dietary protein sources and risk of overall and cause-specific mortality in The Netherlands Cohort Study

(2019) Piet A. van den Brandt   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Low protein and methionine, high starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and has little effect on adiposity in mice

(2019) Catherine Chaumontet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mammalian Target of Rapamycin

(2019) Matthew F. Wipperman et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway

(2019) Maria Donniacuo et al.   LIFE SCIENCES

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

The impact of dietary protein intake on longevity and metabolic health

(2019) Munehiro Kitada et al.   EBioMedicine

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

(2019) Lukas Schwingshackl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hormetic Effects of Phytochemicals on Health and Longevity

(2019) Jan Martel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome

(2019) Agnieszka Gadecka et al.   Nutrients

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

Towards a unified mechanistic theory of aging

(2019) Gustavo Barja   EXPERIMENTAL GERONTOLOGY

[PROVISIONAL] Growth Hormone Insensitivity (Laron syndrome): report of a new family and review of Brazilian patients

(2019) Thais R. Villela et al.   GENETICS AND MOLECULAR BIOLOGY

Nutrition and longevity – From mechanisms to uncertainties

(2019) Cem Ekmekcioglu   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition

(2019) Rinninella et al.   Nutrients

Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity

(2019) Sebastian Brandhorst et al.   Advances in Nutrition

Current nutritional and pharmacological anti-aging interventions

(2019) Manuel Ros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

(2018) Claudia Schwarz et al.   Aging-US

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Homeostatic sensing of dietary protein restriction: A case for FGF21

(2018) Cristal M. Hill et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Small Molecules as SIRT Modulators

(2018) Xinfa Bai et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Dietary Tryptophan Restriction Dose-Dependently Modulates Energy Balance, Gut Hormones, and Microbiota in Obesity-Prone Rats

(2018) Rizaldy C. Zapata et al.   Obesity

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Role of Dietary Protein and Muscular Fitness on Longevity and Aging

(2018) Barbara Strasser et al.   Aging and Disease

Metformin as geroprotector: experimental and clinical evidence

(2018) Veronika Piskovatska et al.   BIOGERONTOLOGY

Regulation of metabolic health by essential dietary amino acids

(2018) Cara L. Green et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The potential nutrigeroprotective role of Mediterranean diet and its functional components on telomere length dynamics

(2018) Sergio Davinelli et al.   AGEING RESEARCH REVIEWS

Programmed longevity, youthspan, and juventology

(2018) Valter D. Longo   AGING CELL

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation

(2018) Ching-Feng Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exceptional Human Longevity

(2018) Robert J. Pignolo   MAYO CLINIC PROCEEDINGS

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

(2018) Hideya Shintani et al.   Nutrients

The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes

(2018) Natalie J. Haywood et al.   Molecular Metabolism

Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules

(2017) Christian Heiss et al.   EXPERIMENTAL GERONTOLOGY

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

Bioactivity of Olive Oil Phenols in Neuroprotection

(2017) Cristina Angeloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of reproduction and longevity by nutrient-sensing pathways

(2017) Nicole M. Templeman et al.   JOURNAL OF CELL BIOLOGY

GH/IGF-I/insulin system in centenarians

(2017) Giovanni Vitale et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of the TOR pathway in mediating the link between nutrition and longevity

(2017) Oleh Lushchak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)

(2017) Albert Pérez-Martí et al.   MOLECULAR NUTRITION & FOOD RESEARCH

FOXO Transcriptional Factors and Long-Term Living

(2017) Ghulam Murtaza et al.   Oxidative Medicine and Cellular Longevity

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

(2017) Julien Peyrol et al.   Nutrients

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study

(2017) Arash Etemadi et al.   BMJ-British Medical Journal

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study

(2017) Arash Etemadi et al.   BMJ-British Medical Journal

Nutrition and lifestyle in healthy aging: the telomerase challenge

(2016) Virginia Boccardi et al.   Aging-US

Signaling Networks Determining Life Span

(2016) Celine E. Riera et al.   Annual Review of Biochemistry

Dietary Protein, Metabolism, and Aging

(2016) George A. Soultoukis et al.   Annual Review of Biochemistry

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

(2016) Lucas D. BonDurant et al.   Annual Review of Nutrition

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms

(2016) Silvia Cetrullo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Posttranscriptional regulation of FOXO expression: microRNAs and beyond

(2016) P Urbánek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

Growth factors, aging and age-related diseases

(2016) Priya Balasubramanian et al.   GROWTH HORMONE & IGF RESEARCH

Epilogue: The future of Laron syndrome — The need for changes

(2016) Zvi Laron   GROWTH HORMONE & IGF RESEARCH

Fifty seven years of follow-up of the Israeli cohort of Laron Syndrome patients—From discovery to treatment

(2016) Zvi Laron et al.   GROWTH HORMONE & IGF RESEARCH

Calorie restriction as an intervention in ageing

(2016) Guillermo López-Lluch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Dietary Restriction and Nutrient Balance in Aging

(2016) Júlia Santos et al.   Oxidative Medicine and Cellular Longevity

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

(2016) Bolormaa Vandanmagsar et al.   Cell Reports

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality

(2016) Mingyang Song et al.   JAMA Internal Medicine

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Macronutrient balance and lifespan

(2016) Stephen J. Simpson et al.   Aging-US

Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

(2016) Martin Weinberger et al.   Aging-US

Calorie restriction mimetics: Can you have your cake and eat it, too?

(2015) Donald K. Ingram et al.   AGEING RESEARCH REVIEWS

Methionine restriction and life-span control

(2015) Byung Cheon Lee et al.   Annals of the New York Academy of Sciences

Dietary restriction, mitochondrial function and aging: from yeast to humans

(2015) Andrea Ruetenik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Adequacy of nutritional intake among older men living in Sydney, Australia: findings from the Concord Health and Ageing in Men Project (CHAMP)

(2015) Rosilene V. R. Waern et al.   BRITISH JOURNAL OF NUTRITION

A Protein Restriction-Dependent Sulfur Code for Longevity

(2015) Hong Seok Shim et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

The impact of low-protein high-carbohydrate diets on aging and lifespan

(2015) David G. Le Couteur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population

(2015) Sonia García-Calzón et al.   CLINICAL NUTRITION

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management

(2015) Silvia Cetrullo et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway

(2015) Kunqian Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

Macronutrients and caloric intake in health and longevity

(2015) S. M. Solon-Biet et al.   JOURNAL OF ENDOCRINOLOGY

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

(2015) Dieuwertje E. G. Kok et al.   Clinical Epigenetics

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes

(2014) Mako Yasuda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

(2014) Nadège Minois   GERONTOLOGY

Mediterranean Diet and Healthy Ageing: A Sicilian Perspective

(2014) Sonya Vasto et al.   GERONTOLOGY

Lifestyle Factors Related to Mortality and Survival: A Mini-Review

(2014) D. Rizzuto et al.   GERONTOLOGY

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Hydroxytyrosol Prevents Increase of Osteoarthritis Markers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene α

(2014) Annalisa Facchini et al.   PLoS One

Protein and amino acid restriction, aging and disease: from yeast to humans

(2014) Hamed Mirzaei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

Mediterranean diet and health

(2013) Francesco Sofi et al.   BIOFACTORS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Effects of Glucose Restriction on Replicative Senescence of Human Diploid Fibroblasts IMR-90

(2013) Junhua Jin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa

(2013) Bradley J. Willcox et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Sirtuins' modulation of autophagy

(2013) Fanny Ng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis

(2013) Allan Lançon et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Nutrient regulation of the mTOR Complex 1 signaling pathway

(2013) Sang Gyun Kim et al.   MOLECULES AND CELLS

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

The GH/IGF-1 axis in ageing and longevity

(2013) Riia K. Junnila et al.   Nature Reviews Endocrinology

SIRT1 metabolic actions: Integrating recent advances from mouse models

(2013) Marie Boutant et al.   Molecular Metabolism

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

The role of PGC-1 coactivators in aging skeletal muscle and heart

(2012) Lloye M. Dillon et al.   IUBMB LIFE

Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance

(2012) Nicole Metes-Kosik et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

(2012) Gene P. Ables et al.   PLoS One

Lessons from C. elegans: signaling pathways for longevity

(2012) Louis R. Lapierre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Diet induced epigenetic changes and their implications for health

(2011) J. A. McKay et al.   Acta Physiologica

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts

(2011) Catherine L. Passariello et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Adipose Endocrine Function, Insulin-Like Growth Factor-1 Axis, and Exceptional Survival Beyond 100 Years of Age

(2011) Y. Arai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

A twin approach to unraveling epigenetics

(2011) Jordana T. Bell et al.   TRENDS IN GENETICS

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase

(2010) Amany K. Elshorbagy et al.   JOURNAL OF LIPID RESEARCH

Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study

(2010) Ramon Estruch   PROCEEDINGS OF THE NUTRITION SOCIETY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

(2009) B. Viollet et al.   Acta Physiologica

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Dietary Protein, Weight Loss, and Weight Maintenance

(2009) M.S. Westerterp-Plantenga et al.   Annual Review of Nutrition

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

(2009) Antoine E. Roux et al.   PLoS Genetics

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans

(2008) Luigi Fontana et al.   AGING CELL

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Evidence for dietary regulation of microRNA expression in cancer cells

(2008) Cindy D Davis et al.   NUTRITION REVIEWS

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics